Human mesenchymal stem cells are recruited to injured liver in a β1‐integrin and CD44 dependent manner

Victoria Aldridge, Abhilok Garg, Nicholas Davies, David C. Bartlett, Janine Youster, Heather Beard, Dean P. Kavanagh, Neena Kalia, Jon Frampton, Patricia F. Lalor, Philip N. Newsome – 15 March 2012 – Human bone marrow mesenchymal stem cells (hMSCs) have shown benefit in clinical trials of patients with liver disease. Efficient delivery of cells to target organs is critical to improving their effectiveness. This requires an understanding of the mechanisms governing cellular engraftment into the liver.

Anesthesia for liver transplantation in US academic centers: Institutional structure and perioperative care

Ann Walia, M. Susan Mandell, Nathaniel Mercaldo, Damon Michaels, Amy Robertson, Arna Banerjee, Ramachander Pai, John Klinck, Matthew Weinger, Pratik Pandharipande, Roman Schumann – 12 March 2012 – Investigators at a single institution have shown that the organization of the anesthesia team influences patient outcomes after liver transplant surgery. Little is known about how liver transplant anesthesiologists are organized to deliver care throughout the United States.

Early bedside detection of ischemia and rejection in liver transplants by microdialysis

Håkon Haugaa, Ebbe B. Thorgersen, Anne Pharo, Kirsten M. Boberg, Aksel Foss, Pål Dag Line, Truls Sanengen, Runar Almaas, Guro Grindheim, Soeren Erik Pischke, Tom Eirik Mollnes, Tor Inge Tønnessen – 12 March 2012 – This study was performed to explore whether lactate, pyruvate, glucose, and glycerol levels sampled via microdialysis catheters in the transplanted liver could be used to detect ischemia and/or rejection. The metabolites were measured at the bedside every 1 to 2 hours after the operation for a median of 10 days.

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