Cholangiocarcinoma: A cancer in search of the right classification
Vincenzo Cardinale, Guido Carpino, Lola M. Reid, Eugenio Gaudio, Domenico Alvaro – 12 March 2012
Antiviral or proviral action of mycophenolic acid in hepatitis B infection?
Qiuwei Pan, Anneke J. van Vuuren, Luc J.W. van der Laan, Maikel P. Peppelenbosch, Harry L. A. Janssen – 10 March 2012
S‐adenosyl methionine regulates ubiquitin‐conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers
Maria Lauda Tomasi, Ivan Tomasi, Komal Ramani, Rosa Maria Pascale, Jun Xu, Pasquale Giordano, José M. Mato, Shelly C. Lu – 10 March 2012 – Ubiquitin‐conjugating enzyme 9 (Ubc9) is required for sumoylation and is overexpressed in several malignancies, but its expression in hepatocellular carcinoma (HCC) is unknown. Hepatic S‐adenosyl methionine (SAMe) levels decrease in methionine adenosyltransferase 1A (Mat1a) knockout (KO) mice, which develop HCC, and in ethanol‐fed mice.
Human immunodeficiency virus protease inhibitors modulate Ca2+ homeostasis and potentiate alcoholic stress and injury in mice and primary mouse and human hepatocytes
Eddy Kao, Masao Shinohara, Min Feng, Mo Yin Lau, Cheng Ji – 10 March 2012 – A portion of human immunodeficiency virus (HIV)‐infected patients undergoing protease inhibitor (PI) therapy concomitantly consume or abuse alcohol leading to hepatic injury. The underling mechanisms are not known. We hypothesize that HIV PIs aggravate alcohol‐induced liver injury through an endoplasmic reticulum (ER) stress mechanism. To address this, we treated mice, primary mouse hepatocytes (PMHs), and primary human hepatocytes (PHHs) with alcohol and the HIV PIs ritonavir (RIT) and lopinavir (LOP).
The horizon: New targets and new agents
Alison B. Jazwinski, Andrew J. Muir – 6 March 2012 – Watch the interview with the authors
Demographics of hepatitis C virus today
Stevan A. Gonzalez, Gary L. Davis – 6 March 2012 – Watch the interview with the authors
Demographics of hepatitis C virus today
Stevan A. Gonzalez, Gary L. Davis – 6 March 2012 – Watch the interview with the authors
The new standard of HCV therapy: Treatment in therapy‐naive patients
Saurabh Agrawal, Paul Y. Kwo – 6 March 2012 – Watch the interview with the authors
The long‐term horizon: Patients who will remain untreated in the era of triple therapy
Andrew Aronsohn, Donald Jensen – 6 March 2012 – Watch the interview with the authors
The new standard of HCV therapy: Treatment in therapy‐naive patients
Saurabh Agrawal, Paul Y. Kwo – 6 March 2012 – Watch the interview with the authors