Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients

Carlos Benítez, María‐Carlota Londoño, Rosa Miquel, Tommaso‐Maria Manzia, Juan G. Abraldes, Juan‐José Lozano, Marc Martínez‐Llordella, Marta López, Roberta Angelico, Felix Bohne, Pilar Sese, Frederic Daoud, Patrick Larcier, Dave L. Roelen, Frans Claas, Gavin Whitehouse, Jan Lerut, Jacques Pirenne, Antoni Rimola, Giuseppe Tisone, Alberto Sánchez‐Fueyo – 26 March 2013 – Lifelong immunosuppression increases morbidity and mortality in liver transplantation.

Mutual interaction between YAP and CREB promotes tumorigenesis in liver cancer

Jiayi Wang, Lifang Ma, Wenhao Weng, Yongxia Qiao, Yue Zhang, Jiangtu He, Hongmei Wang, Weifan Xiao, Lanlan Li, Qinghua Chu, Qiuhui Pan, Yongchun Yu, Fenyong Sun – 26 March 2013 – Yes‐associated protein (YAP), the downstream effecter of the Hippo‐signaling pathway as well as cyclic adenosine monophosphate response element‐binding protein (CREB), has been linked to hepatocarcinogenesis. However, little is known about whether and how YAP and CREB interact with each other.

Synergism of tapasin and human leukocyte antigens in resolving hepatitis C virus infection

Shirin Ashraf, Katja Nitschke, Usama M. Warshow, Collin R. Brooks, Arthur Y. Kim, Georg M. Lauer, Theresa J. Hydes, Matthew E. Cramp, Graeme Alexander, Ann‐Margaret Little, Robert Thimme, Christoph Neumann‐Haefelin, Salim I. Khakoo – 26 March 2013 – CD8+ T‐cell responses to hepatitis C virus (HCV) are important in generating a successful immune response and spontaneously clearing infection. Human leukocyte antigen (HLA) class I presents viral peptides to CD8+ T cells to permit detection of infected cells, and tapasin is an important component of the peptide loading complex for HLA class I.

Genotype‐phenotype relationships in the low‐phospholipid‐associated cholelithiasis syndrome: A study of 156 consecutive patients

Raoul Poupon, Olivier Rosmorduc, Pierre Yves Boëlle, Yves Chrétien, Christophe Corpechot, Olivier Chazouillères, Chantal Housset, Véronique Barbu – 26 March 2013 – The low‐phospholipid‐associated cholelithiasis syndrome (LPAC; OMIM 171060) is a peculiar form of intrahepatic cholelithiasis occurring in young adults, associated with ABCB4/MDR3 gene sequence variations. Our aim was to determine the genotype‐phenotype relationships in 156 consecutive patients with the criteria of LPAC syndrome.

Clonality, activated antigen‐specific CD8+ T cells, and development of autoimmune cholangitis in dnTGFβRII mice

Kazuhito Kawata, Guo‐Xiang Yang, Yugo Ando, Hajime Tanaka, Weici Zhang, Yoshimasa Kobayashi, Koichi Tsuneyama, Patrick S.C. Leung, Zhe‐Xiong Lian, William M. Ridgway, Aftab A. Ansari, Xiao‐Song He, M. Eric Gershwin – 26 March 2013 – There are several murine models described with features similar to human primary biliary cirrhosis (PBC). Among these models, the one which has the closest serologic features to PBC is a mouse with a T‐cell‐restricted expression of the dominant negative transforming growth factor β receptor type II (dnTGFβRII).

Subscribe to