The new standard of HCV therapy: Retreatment in experienced patients
Naveen Gara, Marc G. Ghany – 6 March 2012 – Watch the interview with the authors
The new standard of HCV therapy: Treatment in therapy‐naive patients
Saurabh Agrawal, Paul Y. Kwo – 6 March 2012 – Watch the interview with the authors
The long‐term horizon: Patients who will remain untreated in the era of triple therapy
Andrew Aronsohn, Donald Jensen – 6 March 2012 – Watch the interview with the authors
The new standard of HCV therapy: Treatment in therapy‐naive patients
Saurabh Agrawal, Paul Y. Kwo – 6 March 2012 – Watch the interview with the authors
Demographics of hepatitis C virus today
Stevan A. Gonzalez, Gary L. Davis – 6 March 2012 – Watch the interview with the authors
Demographics of hepatitis C virus today
Stevan A. Gonzalez, Gary L. Davis – 6 March 2012 – Watch the interview with the authors
The horizon: New targets and new agents
Alison B. Jazwinski, Andrew J. Muir – 6 March 2012 – Watch the interview with the authors
Androgen pathway stimulates MicroRNA‐216a transcription to suppress the tumor suppressor in lung cancer‐1 gene in early hepatocarcinogenesis
Po‐Jen Chen, Shiou‐Hwei Yeh, Wan‐Hsin Liu, Chen‐Ching Lin, Hsuan‐Cheng Huang, Chi‐Ling Chen, Ding‐Shinn Chen, Pei‐Jer Chen – 5 March 2012 – Deregulation of microRNAs (miRNAs) is common in advanced human hepatocellular carcinoma (HCC); however, the ones involved in early carcinogenesis have not yet been investigated. By examining the expression of 22 HCC‐related miRNAs between precancerous and cancerous liver tissues, we found miR‐216a and miR‐224 were significantly up‐regulated, starting from the precancerous stage.
Hepatocyte senescence in vivo following preconditioning for liver repopulation
Maria Paola Serra, Fabio Marongiu, Marcella Sini, Ezio Laconi – 5 March 2012 – In the retrorsine (RS)‐based model of massive liver repopulation, preexposure to this naturally occurring alkaloid is sufficient to prime normal host parenchymal cells to be slowly replaced by transplanted normal hepatocytes. The basis for this striking effect is yet to be fully elucidated. In the present studies the possible involvement of cell senescence was investigated.
Histone deacetylase 6 functions as a tumor suppressor by activating c‐Jun NH2‐terminal kinase‐mediated beclin 1‐dependent autophagic cell death in liver cancer
Kwang Hwa Jung, Ji Heon Noh, Jeong Kyu Kim, Jung Woo Eun, Hyun Jin Bae, Young Gyoon Chang, Min Gyu Kim, Won Sang Park, Jung Young Lee, Sang‐Yeop Lee, In‐Sun Chu, Suk Woo Nam – 5 March 2012 – Ubiquitin‐binding histone deacetylase 6 (HDAC6) is uniquely endowed with tubulin deacetylase activity and plays an important role in the clearance of misfolded protein by autophagy. In cancer, HDAC6 has become a target for drug development due to its major contribution to oncogenic cell transformation.