Role of regulatory T cells in the promotion of transplant tolerance
Itay Shalev, Nazia Selzner, Wendy Shyu, David Grant, Gary Levy – 21 April 2012 – Liver transplantation is now recognized as the most effective therapy for patients with end‐stage acute and chronic liver failure. Despite outstanding short‐term graft and patient survival, liver transplantation continues to face several major challenges, including poor long‐term graft survival due to chronic rejection and major side effects of long‐term immunosuppressive therapy (which is required for the prevention of rejection).