Stepan Sembera, Craig Lammert, Jayant A. Talwalkar, Schuyler O. Sanderson, John J. Poterucha, J. Eileen Hay, Russell H. Wiesner, Gregory J. Gores, Charles B. Rosen, Julie K. Heimbach, Michael R. Charlton – 5 March 2012 – Drug‐induced liver injury (DILI) is increasingly being recognized as a common cause of acute hepatitis. The clinical impact of DILI after liver transplantation (LT) is not known. The aim of this study was to describe the frequency, clinical presentation, and outcomes of DILI in LT recipients.

Junfeng An, Christoph Harms, Gisela Lättig‐Tünnemann, Gernot Sellge, Ana D. Mandić, Yann Malato, Arnd Heuser, Matthias Endres, Christian Trautwein, Stefan Donath – 5 March 2012 – Acute liver failure (ALF) is associated with massive hepatocyte cell death and high mortality rates. Therapeutic approaches targeting hepatocyte injury in ALF are hampered by the activation of distinct stimulus‐dependent pathways, mechanism of cell death, and a limited therapeutic window.

Laura Gomez‐Santos, Zigmund Luka, Conrad Wagner, Sara Fernandez‐Alvarez, Shelly C. Lu, Jose M. Mato, Maria L. Martinez‐Chantar, Naiara Beraza – 5 March 2012 – Glycine N‐methyltransferase (GNMT) catabolizes S‐adenosylmethionine (SAMe), the main methyl donor of the body. Patients with cirrhosis show attenuated GNMT expression, which is absent in hepatocellular carcinoma (HCC) samples. GNMT−/− mice develop spontaneous steatosis that progresses to steatohepatitis, cirrhosis, and HCC.

Jose D. Debes, Coleman I. Smith – 5 March 2012

Robin K. Kelley, Ryutaro Hirose, Alan P. Venook – 5 March 2012

Joseph F. Perz, Scott Grytdal, Suzanne Beck, Ana Maria Fireteanu, Tasha Poissant, Elena Rizzo, Katherine Bornschlegel, Ann Thomas, Sharon Balter, Jeremy Miller, R. Monina Klevens, Lyn Finelli – 2 March 2012 – Reports of hepatitis B virus (HBV) and hepatitis C virus (HCV) transmission associated with unsafe medical practices have been increasing in the United States. However, the contribution of healthcare exposures to the burden of new infections is poorly understood outside of recognized outbreaks.

Sumeet K. Asrani, Nina S. Asrani, Deborah K. Freese, Sabrina D. Phillips, Carole A. Warnes, Julie Heimbach, Patrick S. Kamath – 2 March 2012 – There are approximately 1 million adult patients with congenital heart disease (CHD) in the United States, and the number is increasing. Hepatic complications are common and may occur secondary to persistent chronic passive venous congestion or decreased cardiac output resulting from the underlying cardiac disease or as a result of palliative cardiac surgery; transfusion or drug‐related hepatitis may also occur.

Maureen M. Jonas, William Balistreri, Regino P. Gonzalez‐Peralta, Barbara Haber, Steven Lobritto, Parvathi Mohan, Jean P. Molleston, Karen F. Murray, Michael R. Narkewicz, Philip Rosenthal, Kathleen B. Schwarz, Bruce A. Barton, John A. Shepherd, Paul D. Mitchell, Christopher Duggan – 2 March 2012 – Weight loss and changes in growth are noted in children treated with interferon alpha (IFN‐α). The aim of this study was to prospectively determine changes in weight, height, body mass index (BMI), and body composition during and after treatment of children with hepatitis C virus (HCV).

Jesús M. Banales, Elena Sáez, Miriam Úriz, Sarai Sarvide, Aura D. Urribarri, Patrick Splinter, Pamela S. Tietz Bogert, Luis Bujanda, Jesús Prieto, Juan F. Medina, Nicholas F. LaRusso – 2 March 2012 – Cl−/HCO anion exchanger 2 (AE2) participates in intracellular pH homeostasis and secretin‐stimulated biliary bicarbonate secretion. AE2/SLC4A2 gene expression is reduced in liver and blood mononuclear cells from patients with primary biliary cirrhosis (PBC).

Roheeth D. Delima, Anita C.G. Chua, Janina E.E. Tirnitz‐Parker, Eng K. Gan, Kevin D. Croft, Ross M. Graham, John K. Olynyk, Debbie Trinder – 2 March 2012 – Mutations in hemochromatosis protein (HFE) or transferrin receptor 2 (TFR2) cause hereditary hemochromatosis (HH) by impeding production of the liver iron‐regulatory hormone, hepcidin (HAMP). This study examined the effects of disruption of Hfe or Tfr2, either alone or together, on liver iron loading and injury in mouse models of HH.