Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid‐induced liver injury in superobese patients with nonalcoholic steatohepatitis

Lars P. Bechmann, Peri Kocabayoglu, Jan‐Peter Sowa, Svenja Sydor, Jan Best, Martin Schlattjan, Anja Beilfuss, Johannes Schmitt, Rebekka A. Hannivoort, Alpaslan Kilicarslan, Christian Rust, Frieder Berr, Oliver Tschopp, Guido Gerken, Scott L. Friedman, Andreas Geier, Ali Canbay – 8 January 2013 – Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in industrialized countries and may proceed to steatohepatitis (NASH). Apoptosis and free fatty acid (FFA)‐induced lipotoxicity are important features of NASH pathogenesis.

Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models

Stephanie Coulon, Vanessa Legry, Femke Heindryckx, Christophe Van Steenkiste, Christophe Casteleyn, Kim Olievier, Louis Libbrecht, Peter Carmeliet, Bart Jonckx, Jean‐Marie Stassen, Hans Van Vlierberghe, Isabelle Leclercq, Isabelle Colle, Anja Geerts – 8 January 2013 – The pathophysiology of nonalcoholic steatohepatitis (NASH) should be approached as a multifactorial process. In several stages of NASH, a link between disease progression and hepatic microvasculature changes can be made.

Improvement of neurocognitive function in responders to an antiviral therapy for chronic hepatitis C

Michael R. Kraus, Arne Schäfer, Gerlinde Teuber, Heiner Porst, Kathrin Sprinzl, Sven Wollschläger, Christian Keicher, Michael Scheurlen – 8 January 2013 – Earlier studies have suggested neurocognitive impairment in patients with chronic hepatitis C virus (HCV) infection even before liver cirrhosis has developed. Since these deficits might be reversible after successful antiviral therapy, we analyzed the long‐term course of neurocognitive parameters in HCV patients with and without successful virus elimination by an interferon‐based antiviral treatment.

Hepatitis B virus hepatotropism is mediated by specific receptor recognition in the liver and not restricted to susceptible hosts

Alexa Schieck, Andreas Schulze, Caroline Gähler, Thomas Müller, Uwe Haberkorn, Alexander Alexandrov, Stephan Urban, Walter Mier – 4 January 2013 – The human hepatitis B virus (HBV) causes acute and chronic infections in humans and chimpanzees. HBV infects its hosts at minimal inoculation doses and replicates exclusively in hepatocytes. The viral determinants for the pronounced species specificity and the high efficacy to address hepatocytes in vivo are unknown.

Long‐term management of the successful adult liver transplant: 2012 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation

Subscribe to