Megakaryocytes promote hepatoepithelial liver cell development in E11.5 mouse embryos by cell‐to‐cell contact and by vascular endothelial growth factor A signaling

Natalia Serrano, Isabel Cortegano, Carolina Ruiz, Mario Alía, Belén de Andrés, María Teresa Rejas, Miguel A.R. Marcos, María Luisa Gaspar – 21 May 2012 – In the mouse embryo, hematopoietic progenitor cells migrate to the fetal liver (FL) between gestational days (E) 9.5 and 10.5, where they rapidly expand to form the main fetal reservoir of hematopoietic cells. The embryonic megakaryocyte progenitors (MKPs) in the E11.5 FL were identified as CD49fHCD41H (and c‐KitDKDR+CD42+CD9++CD31+) cells, expressing several hepato‐specific proteins.

Tracing hepatitis B virus to the 16th century in a Korean mummy

Gila Kahila Bar‐Gal, Myeung Ju Kim, Athalia Klein, Dong Hoon Shin, Chang Seok Oh, Jong Wan Kim, Tae‐Hyun Kim, Seok Bae Kim, Paul R. Grant, Orit Pappo, Mark Spigelman, Daniel Shouval – 21 May 2012 – A rare find of a mummified child from the 16th century AD, in Korea, with relatively preserved organs, enabled a search for ancient hepatitis B virus (aHBV) DNA sequences from laparoscopic‐derived liver biopsies.

Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations

James E. Nelson, Elizabeth M. Brunt, Kris V. Kowdley, for the Nonalcoholic Steatohepatitis Clinical Research Network – 21 May 2012 – Hepcidin regulation is linked to both iron and inflammatory signals and may influence iron loading in nonalcoholic steatohepatitis (NASH). The aim of this study was to examine the relationships among HFE genotype, serum hepcidin level, hepatic iron deposition, and histology in nonalcoholic fatty liver disease (NAFLD).

Interaction between intestinal dendritic cells and bacteria translocated from the gut in rats with cirrhosis

Leticia Muñoz, María José Borrero, María Ubeda, Margaret Lario, David Díaz, Rubén Francés, Jorge Monserrat, Óscar Pastor, Elia Aguado‐Fraile, José Such, Melchor Álvarez‐Mon, Agustín Albillos – 21 May 2012 – Cirrhosis with ascites is associated with a high rate of gut bacterial translocation (GBT) and spontaneous bacterial infections of enteric origin. We addressed the activation state and role of intestinal dendritic cells (DCs) in experimental ascitic cirrhosis and their relationship with GBT. Cirrhosis with ascites was CCl4 induced in rats.

Patients transplanted for nonalcoholic steatohepatitis are at increased risk for postoperative cardiovascular events

Lisa B. VanWagner, Manali Bhave, Helen S. Te, Joe Feinglass, Lisa Alvarez, Mary E. Rinella – 21 May 2012 – Nonalcoholic steatohepatitis (NASH) is an independent predictor of coronary artery disease (CAD). Our aim was to compare the incidence of cardiovascular (CV) events between patients transplanted for NASH and alcohol (ETOH)‐induced cirrhosis. This is a retrospective cohort study (August 1993 to March 2010) of 242 patients (115 NASH and 127 ETOH) with ≥12 months follow‐up after liver transplantation (LT). Those with hepatocellular carcinoma or coexisting liver diseases were excluded.

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