Comprehensive analysis for viral elements and interleukin‐28B polymorphisms in response to pegylated interferon plus ribavirin therapy in hepatitis C virus 1B infection
Shinya Maekawa, Minoru Sakamoto, Mika Miura, Makoto Kadokura, Ryota Sueki, Kazuki Komase, Hiroko Shindo, Nobutoshi Komatsu, Kuniaki Shindo, Asuka Kanayama, Takako Ohmori, Fumitake Amemiya, Shinichi Takano, Tatsuya Yamaguchi, Yasuhiro Nakayama, Takatoshi Kitamura, Taisuke Inoue, Shunichi Okada, Nobuyuki Enomoto – 10 May 2012 – To comprehensively characterize the contribution of virological factors as well as interleukin‐28B (IL28B) single‐nucleotide polymorphisms (SNPs) in determining treatment responses in pegylated‐interferon plus ribavirin (Peg‐IFN/RBV) therapy for chronic hepatitis C vir
Describing the role of ethnicity in the progression of NAFLD: Easier said than done?
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Edward William Holt – 10 May 2012
In reference to higher serum testosterone is associated with increased risk of advanced hepatitis c‐related liver disease in males
Marie Sinclair, Mathis Grossmann, Paul Gow, Peter Angus – 10 May 2012
Metabolic oxidation controls the hepatic stem cells (HpSCs) fate and the hepatic lineage organization in physiologic and pathologic conditions
Vincenzo Cardinale, Guido Carpino, Alfredo Cantafora, Lola M. Reid, Eugenio Gaudio, Domenico Alvaro – 10 May 2012
Invasive fungal infections following liver transplantation: Incidence, risk factors, survival, and impact of fluconazole‐resistant Candida parapsilosis (2003‐2007)
Anupama Raghuram, Alejandro Restrepo, Saman Safadjou, Jennifer Cooley, Mark Orloff, Dwight Hardy, Sam Butler, Christine E. Koval – 10 May 2012 – Invasive fungal infections (IFIs) are associated with a high mortality rate for liver transplantation (LT) recipients. To study the incidence of and risk factors for IFIs in LT recipients and the associated mortality rates, we retrospectively reviewed the records of first‐time deceased donor LT recipients (January 2003 to December 2007). The incidence of IFIs was 12%.
Deletion of interleukin (IL)‐12p35 induces liver fibrosis in dominant‐negative TGFβ receptor type II mice
Masanobu Tsuda, Weici Zhang, Guo‐Xiang Yang, Koichi Tsuneyama, Yugo Ando, Kazuhito Kawata, Ogyi Park, Patrick S.C. Leung, Ross L. Coppel, Aftab A. Ansari, William M. Ridgway, Bin Gao, Zhe‐Xiong Lian, Richard Flavell, Xiao‐Song He, M.Eric Gershwin – 10 May 2012 – Mice with a dominant‐negative transforming growth factor β receptor restricted to T cells (dnTGFβRII mice) develop an inflammatory biliary ductular disease that strongly resembles human primary biliary cirrhosis (PBC).
Common genetic variation in vitamin D metabolism is associated with liver stiffness
Frank Grünhage, Katrin Hochrath, Marcin Krawczyk, Aksana Höblinger, Barbara Obermayer‐Pietsch, Jürgen Geisel, Michael Trauner, Tilman Sauerbruch, Frank Lammert – 10 May 2012 – Recently, genome‐wide studies identified genetic variants that affect serum 25‐hydroxyvitamin D levels in healthy populations (rs12785878, near dehydrocholesterol reductase, DHCR7; rs10741657, at CYP2R1; and rs7041, at vitamin D binding protein, GC).
CD81/CD9 tetraspanins aid plasmacytoid dendritic cells in recognition of hepatitis C virus–infected cells and induction of interferon‐alpha
Shuye Zhang, Karen Kodys, Gregory J. Babcock, Gyongyi Szabo – 10 May 2012 – Recognition of hepatitis C virus (HCV)‐infected hepatocyes and interferon (IFN) induction are critical in antiviral immune response. We hypothesized that cell‐cell contact between plasmacytoid dendritic cells (pDCs) and HCV‐infected cells was required for IFN‐α induction through the involvement of cell‐surface molecules.
Human antigen R contributes to hepatic stellate cell activation and liver fibrosis
Ashwin Woodhoo, Marta Iruarrizaga‐Lejarreta, Naiara Beraza, Juan L García‐Rodríguez, Nieves Embade, David Fernández‐Ramos, Nuria Martínez‐López, Virginia Gutiérrez‐De Juan, Beatriz Arteta, Juan Caballeria, Shelly C Lu, José M Mato, Marta Varela‐Rey, María L Martínez‐Chantar – 10 May 2012 – RNA‐binding proteins (RBPs) play a major role in the control of messenger RNA (mRNA) turnover and translation rates. We examined the role of the RBP, human antigen R (HuR), during cholestatic liver injury and hepatic stellate cell (HSC) activation.