Should we change the priority for liver allocation for patients with the highest MELD score?
Richard B. Freeman, Russell Wiesner – 16 November 2011
Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survival after partial hepatectomy in mice
Ji Ling, Todd Chaba, Lin‐Fu Zhu, René L. Jacobs, Dennis E. Vance – 16 November 2011 – A major predictor of failed liver resection and transplantation is nonalcoholic fatty liver disease (NAFLD). NAFLD is linked to a wide spectrum of diseases including obesity and diabetes that are increasingly prevalent in Western populations. Thus, it is important to develop therapies aimed at improving posthepatectomy outcomes in patients with NAFLD, as well as to improve the evaluation of patients slated for hepatic surgery.
Endoplasmic reticulum‐tethered transcription factor cAMP responsive element‐binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice
Chunbin Zhang, Guohui Wang, Ze Zheng, Krishna Rao Maddipati, Xuebao Zhang, Gregory Dyson, Paul Williams, Stephen A. Duncan, Randal J. Kaufman, Kezhong Zhang – 16 November 2011 – cAMP responsive element‐binding protein, hepatocyte specific (CREBH), is a liver‐specific transcription factor localized in the endoplasmic reticulum (ER) membrane. Our previous work demonstrated that CREBH is activated by ER stress or inflammatory stimuli to induce an acute‐phase hepatic inflammation.
Albumin infusion in patients undergoing large‐volume paracentesis: A meta‐analysis of randomized trials
Mauro Bernardi, Paolo Caraceni, Roberta J. Navickis, Mahlon M. Wilkes – 16 November 2011 – Albumin infusion reduces the incidence of postparacentesis circulatory dysfunction among patients with cirrhosis and tense ascites, as compared with no treatment. Treatment alternatives to albumin, such as artificial colloids and vasoconstrictors, have been widely investigated. The aim of this meta‐analysis was to determine whether morbidity and mortality differ between patients receiving albumin versus alternative treatments.
Lysine acetylation induced by chronic ethanol consumption impairs dynamin‐mediated clathrin‐coated vesicle release
Blythe D. Shepard, Dean J. Tuma, Pamela L. Tuma – 16 November 2011 – The liver is the major site of ethanol metabolism and thus sustains the most injury from chronic alcohol consumption. Ethanol metabolism by the hepatocyte leads to the generation of reactive metabolites and oxygen radicals that can readily adduct DNA, lipids, and proteins. More recently, it has become apparent that ethanol consumption also leads to increased post‐translational modifications of the natural repertoire, including lysine hyperacetylation.
Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation
Nieves Embade, David Fernández‐Ramos, Marta Varela‐Rey, Naiara Beraza, Marcella Sini, Virginia Gutiérrez de Juan, Ashwin Woodhoo, Nuria Martínez‐López, Begoña Rodríguez‐Iruretagoyena, Francisco Javier Bustamante, Ana Belén de la Hoz, Arkaitz Carracedo, Dimitris P. Xirodimas, Manuel S. Rodríguez, Shelly C. Lu, José M. Mato, María L. Martínez‐Chantar – 16 November 2011 – Hu antigen R (HuR) is a central RNA‐binding protein regulating cell dedifferentiation, proliferation, and survival, which are well‐established hallmarks of cancer.
Re: Indeterminate 1‐2 cm nodules found on hepatocellular carcinoma surveillance: Biopsy for all, some, or none?
Massimo Iavarone, Angelo Sangiovanni – 16 November 2011
Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon‐alpha and ribavirin therapy
Christian M. Lange, Zoltan Kutalik, Kenichi Morikawa, Stéphanie Bibert, Andreas Cerny, Günter Dollenmaier, Jean‐François Dufour, Tilman J. Gerlach, Markus H. Heim, Raffaele Malinverni, Beat Müllhaupt, Francesco Negro, Darius Moradpour, Pierre‐Yves Bochud, the Swiss Hepatitis C Cohort Study Group – 16 November 2011 – Elevated serum ferritin levels may reflect a systemic inflammatory state as well as increased iron storage, both of which may contribute to an unfavorable outcome of chronic hepatitis C (CHC).
Hepatitis C viral kinetics with the nucleoside polymerase inhibitor mericitabine (RG7128)
Jeremie Guedj, Harel Dahari, Emi Shudo, Patrick Smith, Alan S. Perelson – 16 November 2011 – Mericitabine (RG7128) is a nucleoside polymerase inhibitor (NPI), which requires intracellular uptake and phosphorylation to two active triphosphates. Mathematical modeling has provided important insights for characterizing hepatitis C virus (HCV) RNA decline and estimating in vivo effectiveness of antiviral agents; however, it has not been used to characterize viral kinetics with NPIs.
Intestinal bacterial translocation in rats with cirrhosis is related to compromised paneth cell antimicrobial host defense
Zora Teltschik, Reiner Wiest, Julia Beisner, Sabine Nuding, Claudia Hofmann, Juergen Schoelmerich, Charles L. Bevins, Eduard F. Stange, Jan Wehkamp – 16 November 2011 – Liver cirrhosis is associated with bacterial translocation (BT) and endotoxemia. Most translocating bacteria belong to the common intestinal microbiota, suggesting a breakdown of intestinal barrier function. We hypothesized that diminished mucosal antimicrobial host defense could predispose to BT.