Staging hepatic fibrosis: Computer‐aided analysis of hepatic contours on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid‐enhanced hepatocyte‐phase magnetic resonance imaging

Satoshi Goshima, Masayuki Kanematsu, Tatsunori Kobayashi, Takahiro Furukawa, Xuejun Zhang, Hiroshi Fujita, Haruo Watanabe, Hiroshi Kondo, Noriyuki Moriyama, Kyongtae T. Bae – 19 September 2011

Left lobe adult‐to‐adult living donor liver transplantation: Should portal inflow modulation be added?

Yoichi Ishizaki, Seiji Kawasaki, Hiroyuki Sugo, Jiro Yoshimoto, Noriko Fujiwara, Hiroshi Imamura – 19 September 2011 – Recently, the successful application of portal inflow modulation has led to renewed interest in the use of left lobe grafts in adult‐to‐adult living donor liver transplantation (LDLT). However, data on the hepatic hemodynamics supporting portal inflow modulation are limited, and the optimal portal circulation for a liver graft is still unclear. We analyzed 42 consecutive adult‐to‐adult left lobe LDLT cases without splenectomy or a portocaval shunt.

Predictors of the feasibility of primary endoscopic management of biliary strictures after adult living donor liver transplantation

Yun Young Lee, Geum‐Youn Gwak, Kwang Hyuck Lee, Jong Kyun Lee, Kyu Taek Lee, Choon Hyuck David Kwon, Jae‐Won Joh, Suk‐Koo Lee – 6 September 2011 – Biliary strictures are a major cause of morbidity and mortality for liver transplant recipients. The endoscopic management of biliary strictures is not well established after living donor liver transplantation (LDLT) in comparison with deceased donor liver transplantation.

Epidemiology and outcome of infections in human immunodeficiency virus/hepatitis c virus–coinfected liver transplant recipients: A FIPSE/GESIDA Prospective Cohort Study

Asunción Moreno, Carlos Cervera, Jesús Fortún, Marino Blanes, Estibalitz Montejo, Manuel Abradelo, Oscar Len, Antonio Rafecas, Pilar Martín‐Davila, Julián Torre‐Cisneros, Magdalena Salcedo, Elisa Cordero, Ricardo Lozano, Iñaki Pérez, Antonio Rimola, José M. Miró, the OLT‐HIV FIPSE Cohort Investigators – 6 September 2011 – Information about infections unrelated to acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV)–infected liver recipients is scarce.

Transforming growth factor‐beta signaling promotes hepatocarcinogenesis induced by p53 loss

Shelli M. Morris, Ji Yeon Baek, Amanda Koszarek, Samornmas Kanngurn, Sue E. Knoblaugh, William M. Grady – 2 September 2011 – Hepatocellular carcinoma (HCC) results from the accumulation of deregulated tumor suppressor genes and/or oncogenes in hepatocytes. Inactivation of TP53 and inhibition of transforming growth factor‐beta (TGF‐β) signaling are among the most common molecular events in human liver cancers. Thus, we assessed whether inactivation of TGF‐β signaling, by deletion of the TGF‐β receptor, type II (Tgfbr2), cooperates with Trp53 loss to drive HCC formation.

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Núria Tarrats, Anna Moles, Albert Morales, Carmen García‐Ruiz, José C. Fernández‐Checa, Montserrat Marí – 2 September 2011

Comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C: new algorithms are more precise and entirely noninvasive

Jérôme Boursier, Victor de Ledinghen, Jean‐Pierre Zarski, Isabelle Fouchard‐Hubert, Yves Gallois, Frédéric Oberti, Paul Calès, multicentric groups from SNIFF 32, VINDIAG 7, and ANRS/HC/EP23 FIBROSTAR studies – 2 September 2011 – The sequential algorithm for fibrosis evaluation (SAFE) and the Bordeaux algorithm (BA), which cross‐check FibroTest with the aspartate aminotransferase‐to‐platelet ratio index (APRI) or FibroScan, are very accurate but provide only a binary diagnosis of significant fibrosis (SAFE or BA for Metavir F ≥ 2) or cirrhosis (SAFE or BA for F4).

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