Pere Ginès – 19 September 2011

Hong‐Min Ni, Abigail Bockus, Nikki Boggess, Hartmut Jaeschke, Wen‐Xing Ding – 19 September 2011 – Autophagy can selectively remove damaged organelles, including mitochondria, and, in turn, protect against mitochondria‐damage–induced cell death. Acetaminophen (APAP) overdose can cause liver injury in animals and humans by inducing mitochondria damage and subsequent necrosis in hepatocytes. Although many detrimental mechanisms have been reported to be responsible for APAP‐induced hepatotoxicity, it is not known whether APAP can modulate autophagy to regulate hepatotoxicity in hepatocytes.

David Fuks, Safi Dokmak, Valérie Paradis, Momar Diouf, François Durand, Jacques Belghiti – 19 September 2011 – Liver resection (LR) for hepatocellular carcinoma (HCC) as the first‐line treatment in transplantable patients followed by “salvage transplantation” (ST) in case of recurrence is an attractive concept. The aim was to identify patients who gain benefit from this approach in an intention‐to‐treat study.

Simon Hohenester, Lucas Maillette de Buy Wenniger, Coen C. Paulusma, Sandra J. van Vliet, Douglas M. Jefferson, Ronald P. Oude Elferink, Ulrich Beuers – 19 September 2011 – Human cholangiocytes are continuously exposed to millimolar levels of hydrophobic bile salt monomers. We recently hypothesized that an apical biliary HCO umbrella might prevent the protonation of biliary glycine‐conjugated bile salts and uncontrolled cell entry of the corresponding bile acids, and that defects in this biliary HCO umbrella might predispose to chronic cholangiopathies.

Satoshi Goshima, Masayuki Kanematsu, Tatsunori Kobayashi, Takahiro Furukawa, Xuejun Zhang, Hiroshi Fujita, Haruo Watanabe, Hiroshi Kondo, Noriyuki Moriyama, Kyongtae T. Bae – 19 September 2011

Yoichi Ishizaki, Seiji Kawasaki, Hiroyuki Sugo, Jiro Yoshimoto, Noriko Fujiwara, Hiroshi Imamura – 19 September 2011 – Recently, the successful application of portal inflow modulation has led to renewed interest in the use of left lobe grafts in adult‐to‐adult living donor liver transplantation (LDLT). However, data on the hepatic hemodynamics supporting portal inflow modulation are limited, and the optimal portal circulation for a liver graft is still unclear. We analyzed 42 consecutive adult‐to‐adult left lobe LDLT cases without splenectomy or a portocaval shunt.

Yun Young Lee, Geum‐Youn Gwak, Kwang Hyuck Lee, Jong Kyun Lee, Kyu Taek Lee, Choon Hyuck David Kwon, Jae‐Won Joh, Suk‐Koo Lee – 6 September 2011 – Biliary strictures are a major cause of morbidity and mortality for liver transplant recipients. The endoscopic management of biliary strictures is not well established after living donor liver transplantation (LDLT) in comparison with deceased donor liver transplantation.

Asunción Moreno, Carlos Cervera, Jesús Fortún, Marino Blanes, Estibalitz Montejo, Manuel Abradelo, Oscar Len, Antonio Rafecas, Pilar Martín‐Davila, Julián Torre‐Cisneros, Magdalena Salcedo, Elisa Cordero, Ricardo Lozano, Iñaki Pérez, Antonio Rimola, José M. Miró, the OLT‐HIV FIPSE Cohort Investigators – 6 September 2011 – Information about infections unrelated to acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV)–infected liver recipients is scarce.

José M. Mato, Shelly C. Lu – 6 September 2011

Shelli M. Morris, Ji Yeon Baek, Amanda Koszarek, Samornmas Kanngurn, Sue E. Knoblaugh, William M. Grady – 2 September 2011 – Hepatocellular carcinoma (HCC) results from the accumulation of deregulated tumor suppressor genes and/or oncogenes in hepatocytes. Inactivation of TP53 and inhibition of transforming growth factor‐beta (TGF‐β) signaling are among the most common molecular events in human liver cancers. Thus, we assessed whether inactivation of TGF‐β signaling, by deletion of the TGF‐β receptor, type II (Tgfbr2), cooperates with Trp53 loss to drive HCC formation.