Sarcopenia, healthy living, and mortality in patients with chronic liver diseases

Catherine Van Dongen, James M. Paik, Michael Harring, Youssef Younossi, Jillian K. Price, Khaled Kabbara, Pegah Golabi, Zobair M. Younossi – 9 August 2022 – Chronic liver diseases (CLDs) are associated with increased morbidity and mortality. Sarcopenia is an important complication of CLD that can be impacted by several modifiable risk factors. Our aim was to assess the associations between healthy living, sarcopenia, and long‐term outcomes among patients with CLD. We used the Third National Health and Nutrition Examination Survey data with National Death Index–linked mortality files.

Loss of heat shock factor 1 promotes hepatic stellate cell activation and drives liver fibrosis

Asmita Choudhury, Anuradha Ratna, Arlene Lim, Rebecca M. Sebastian, Christopher L. Moore, Aveline A. Filliol, Jacob Bledsoe, Chengkai Dai, Robert F. Schwabe, Matthew D. Shoulders, Pranoti Mandrekar – 8 August 2022 – Liver fibrosis is an aberrant wound healing response that results from chronic injury and is mediated by hepatocellular death and activation of hepatic stellate cells (HSCs). While induction of oxidative stress is well established in fibrotic livers, there is limited information on stress‐mediated mechanisms of HSC activation.

Comparison of a multitarget blood test to ultrasound and alpha‐fetoprotein for hepatocellular carcinoma surveillance: Results of a network meta‐analysis

Amit G. Singal, Benjamin Haaland, Neehar D. Parikh, A. Burak Ozbay, Carol Kirshner, Shubham Chakankar, Kyle Porter, Jagpreet Chhatwal, Turgay Ayer – 8 August 2022 – Ultrasound‐based surveillance has suboptimal sensitivity for early detection of hepatocellular carcinoma (HCC) in patients with cirrhosis. There are several emerging alternatives, including a novel multitarget HCC blood test (Mt‐HBT). We compared performance of mt‐HBT against ultrasound with or without alpha‐fetoprotein (AFP) for early HCC detection in patients with cirrhosis.

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