Antiviral activity of narlaprevir combined with ritonavir and pegylated interferon in chronic hepatitis C patients

Joep de Bruijne, Jilling F. Bergmann, Henk W. Reesink, Christine J. Weegink, Richard Molenkamp, Janke Schinkel, Xiao Tong, Jing Li, Michelle A. Treitel, Eric A. Hughes, Jan Jaap van Lier, Andre A. van Vliet, Harry L. A. Janssen, Robert J. de Knegt – 19 August 2010 – Narlaprevir (SCH 900518) is a potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3 serine protease that is primarily metabolized by the cytochrome P450‐3A4 system.

Hepatitis B virus–DNA level and basal core promoter A1762T/G1764A mutation in liver tissue independently predict postoperative survival in hepatocellular carcinoma

Chau‐Ting Yeh, Mary So, Jennifer Ng, Han‐Wen Yang, Ming‐Ling Chang, Ming‐Wei Lai, Tse‐Ching Chen, Chun‐Yen Lin, Ta‐Sen Yeh, Wei‐Chen Lee – 19 August 2010 – Hepatitis B virus (HBV) is a major etiological factor of hepatocellular carcinoma (HCC). However, the postoperative prognostic value of the virological factors assayed directly from liver tissue has never been investigated. To address this issue, 185 liver samples obtained from the noncancerous part of surgically removed HBV‐associated HCC tissues were subjected to virological analysis.

P2Y13 receptor is critical for reverse cholesterol transport

Aurélie C. Fabre, Camille Malaval, Abduelhakem Ben Addi, Céline Verdier, Véronique Pons, Nizar Serhan, Laeticia Lichtenstein, Guillaume Combes, Thierry Huby, François Briand, Xavier Collet, Niels Nijstad, Uwe J.F. Tietge, Bernard Robaye, Bertrand Perret, Jean‐Marie Boeynaems, Laurent O. Martinez – 19 August 2010 – A major atheroprotective functionality of high‐density lipoproteins (HDLs) is to promote “reverse cholesterol transport” (RCT).

Increased natural killer cell cytotoxicity and NKp30 expression protects against hepatitis C virus infection in high‐risk individuals and inhibits replication in vitro

Lucy Golden‐Mason, Andrea L. Cox, Jessica A. Randall, Linling Cheng, Hugo R. Rosen – 19 August 2010 – CD56pos natural killer (NK)/natural T (NT) cells are important innate effectors providing the first line of defense against viral infection. Enhanced NK activity has been shown to protect from human immunodeficiency virus‐1 infection. However, the role played by these innate effectors in protection against or development of hepatitis C virus (HCV) infection is unknown.

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