Sandro Rossi, Valentina Ravetta, Laura Rosa, Giorgia Ghittoni, Francesca Torello Viera, Francesco Garbagnati, Enrico Maria Silini, Paolo Dionigi, Fabrizio Calliada, Pietro Quaretti, Carmine Tinelli – 7 September 2010 – In most patients with cirrhosis, successful percutaneous ablation or surgical resection of hepatocellular carcinoma (HCC) is followed by recurrence. Radiofrequency ablation (RFA) has proven effective for treating HCC nodules, but its repeatability in managing recurrences and the impact of this approach on survival has not been evaluated.

Sadahisa Okamoto, Rolf Hörnsten, Konen Obayashi, Priyantha Wijayatunga, Ole B. Suhr – 7 September 2010 – In patients with familial amyloidotic polyneuropathy (FAP), heart complications are prognostic factors for mortality and morbidity after liver transplantation (LT). However, only a few studies have analyzed the development of arrhythmia in transplant patients with FAP. We investigated the development of arrhythmia requiring pacemaker insertion (PMI) in Swedish transplant patients with FAP, and we related the findings to gender, age at disease onset, and survival.

María Úbeda, Leticia Muñoz, María‐José Borrero, David Díaz, Rubén Francés, Jorge Monserrat, Margaret Lario, Lourdes Lledó, José Such, Melchor Álvarez‐Mon, Agustín Albillos – 7 September 2010 – Systemic activation of the inflammatory immune system contributes to the progression of cirrhosis with ascites. Immune cells become activated after interacting at the mesenteric lymph nodes (MLNs) with bacteria translocated from the gut, and thereafter reach the bloodstream through recirculation.

Ganesh Gunasekaran, Kalman Bencsath, Vera Hupertz, John J. Fung, Gosta Pettersson, Charles Miller – 7 September 2010 – Liver transplantation is the treatment of choice for many liver diseases in the pediatric population. Complications involving late suprahepatic vena cava obstructions after liver transplantation are not common, but they tend to be more frequently seen in pediatric recipients. When such complications have occurred, approaches involving direct abdominal surgery or interventional radiology guidance have been used with satisfactory results.

Maria Buti, Rafael Esteban – 1 September 2010

Krzysztof P. Rembacz, Jannes Woudenberg, Mark Hoekstra, Elles Z. Jonkers, Fiona A.J. van den Heuvel, Manon Buist‐Homan, Titia E. Woudenberg‐Vrenken, Jana Rohacova, M. Luisa Marin, Miguel A. Miranda, Han Moshage, Frans Stellaard, Klaas Nico Faber – 1 September 2010 – Bile acid‐CoA:amino acid N‐acyltransferase (BAAT) conjugates bile salts to glycine or taurine, which is the final step in bile salt biosynthesis. In addition, BAAT is required for reconjugation of bile salts in the enterohepatic circulation.

Raghavan Chinnadurai, Arash Grakoui – 1 September 2010 – Liver fibrosis is mediated by the transformation of hepatic stellate cells (HSC) from a quiescent to an activated state. To understand the role of HSC in liver immunity, we investigated the effect of this transition on T cell stimulation in vitro. Unlike quiescent HSC, activated HSC did not induce proliferation of antigen‐specific T cells. Phenotypic analysis of quiescent and activated HSC revealed that activated HSC expressed the coinhibitory molecule B7‐H4.

Yun‐Fan Liaw, I‐Shyan Sheen, Chuan‐Mo Lee, Ulus Salih Akarca, George V. Papatheodoridis, Florence Suet‐Hing Wong, Ting‐Tsung Chang, Andrzej Horban, Chia Wang, Peter Kwan, Maria Buti, Martin Prieto, Thomas Berg, Kathryn Kitrinos, Ken Peschell, Elsa Mondou, David Frederick, Franck Rousseau, Eugene R. Schiff – 1 September 2010 – Data are limited on the safety and effectiveness of oral antivirals other than lamivudine and adefovir dipivoxil for treatment of chronic hepatitis B (CHB) in patients with decompensated liver disease.

Michael P. Manns, Albert J. Czaja, James D. Gorham, Edward L. Krawitt, Giorgina Mieli‐Vergani, Diego Vergani, John M. Vierling – 1 September 2010

Hong‐Fang Ji, Liang Shen – 1 September 2010