Linhui Liang, Chun‐Ming Wong, Qiao Ying, Dorothy Ngo‐Yin Fan, Shenglin Huang, Jie Ding, Jian Yao, Mingxia Yan, Jinjun Li, Ming Yao, Irene Oi‐Lin Ng, Xianghuo He – 19 August 2010 – MicroRNAs (miRNAs) are small, noncoding RNAs that can act as oncogenes or tumor suppressors in human cancer. Our previous study showed that miR‐125b was a prognostic indicator for patients with hepatocellular carcinoma (HCC), but its functions and exact mechanisms in hepatic carcinogenesis are still unknown. Here we demonstrate that miR‐125b suppressed HCC cell growth in vitro and in vivo.

Tugrul Purnak, Cumali Efe, Yavuz Beyazit, Ersan Ozaslan – 19 August 2010

Gemma Brufau, Frans Stellaard, Kris Prado, Vincent W. Bloks, Elles Jonkers, Renze Boverhof, Folkert Kuipers, Elizabeth J. Murphy – 19 August 2010 – Bile acids (BAs) are essential for fat absorption and appear to modulate glucose and energy metabolism. Colesevelam, a BA sequestrant, improves glycemic control in type 2 diabetes mellitus (T2DM). We aimed to characterize the alterations in BA metabolism associated with T2DM and colesevelam treatment and to establish whether metabolic consequences of T2DM and colesevelam are related to changes in BA metabolism.

David E. J. Jones, Julia L. Newton – 19 August 2010

Paola Vitaglione, Filomena Morisco, Giovanna Mazzone, Daniela Caterina Amoruso, Maria Teresa Ribecco, Antonietta Romano, Vincenzo Fogliano, Nicola Caporaso, Giuseppe D'Argenio – 19 August 2010 – Epidemiological data associate coffee consumption with a lower prevalence of chronic liver disease and a reduced risk of elevated liver enzyme levels (γ glutamyl transpeptidase and alanine aminotransferase), advanced liver disease and its complications, and hepatocellular carcinoma.

Joep de Bruijne, Jilling F. Bergmann, Henk W. Reesink, Christine J. Weegink, Richard Molenkamp, Janke Schinkel, Xiao Tong, Jing Li, Michelle A. Treitel, Eric A. Hughes, Jan Jaap van Lier, Andre A. van Vliet, Harry L. A. Janssen, Robert J. de Knegt – 19 August 2010 – Narlaprevir (SCH 900518) is a potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3 serine protease that is primarily metabolized by the cytochrome P450‐3A4 system.

Chau‐Ting Yeh, Mary So, Jennifer Ng, Han‐Wen Yang, Ming‐Ling Chang, Ming‐Wei Lai, Tse‐Ching Chen, Chun‐Yen Lin, Ta‐Sen Yeh, Wei‐Chen Lee – 19 August 2010 – Hepatitis B virus (HBV) is a major etiological factor of hepatocellular carcinoma (HCC). However, the postoperative prognostic value of the virological factors assayed directly from liver tissue has never been investigated. To address this issue, 185 liver samples obtained from the noncancerous part of surgically removed HBV‐associated HCC tissues were subjected to virological analysis.

Aurélie C. Fabre, Camille Malaval, Abduelhakem Ben Addi, Céline Verdier, Véronique Pons, Nizar Serhan, Laeticia Lichtenstein, Guillaume Combes, Thierry Huby, François Briand, Xavier Collet, Niels Nijstad, Uwe J.F. Tietge, Bernard Robaye, Bertrand Perret, Jean‐Marie Boeynaems, Laurent O. Martinez – 19 August 2010 – A major atheroprotective functionality of high‐density lipoproteins (HDLs) is to promote “reverse cholesterol transport” (RCT).

Lucy Golden‐Mason, Andrea L. Cox, Jessica A. Randall, Linling Cheng, Hugo R. Rosen – 19 August 2010 – CD56pos natural killer (NK)/natural T (NT) cells are important innate effectors providing the first line of defense against viral infection. Enhanced NK activity has been shown to protect from human immunodeficiency virus‐1 infection. However, the role played by these innate effectors in protection against or development of hepatitis C virus (HCV) infection is unknown.

Zhihua Liu, Yanlei Ma, Huanlong Qin – 18 August 2010