Bijan Raziorrouh, Winfried Schraut, Tilman Gerlach, Daniela Nowack, Norbert H. Grüner, Axel Ulsenheimer, Reinhart Zachoval, Martin Wächtler, Michael Spannagl, Jürgen Haas, Helmut M. Diepolder, Maria‐Christina Jung – 25 August 2010 – Multiple inhibitory receptors may play a role in the weak or absent CD8+ T‐cell response in chronic hepatitis B virus (HBV) infection. Yet few receptors have been characterized in detail and little is known about their complex regulation.

23 August 2010

Yongjun Wang, Rajat Singh, Youqing Xiang, Linda E. Greenbaum, Mark J. Czaja – 20 August 2010 – The sensitization of hepatocytes to cell death from tumor necrosis factor α (TNFα) underlies many forms of hepatic injury, including that from toxins. Critical for hepatocyte resistance to TNFα toxicity is activation of nuclear factor κB (NF‐κB) signaling, which prevents TNFα‐induced death by the up‐regulation of protective proteins.

Zhipeng Meng, Xianghui Fu, Xiaosong Chen, Samuel Zeng, Yan Tian, Richard Jove, Rongzhen Xu, Wendong Huang – 20 August 2010 – MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by interacting with the 3′ untranslated region (3′‐UTR) of multiple mRNAs. Recent studies have linked miRNAs to the development of cancer metastasis. In this study, we show that miR‐194 is specifically expressed in the human gastrointestinal tract and kidney.

Jochen K. M. Lennerz, David J. Kuter, Robert Hasserjian, John Iafrate – 20 August 2010

Luigi Muratori, Paolo Muratori, Giulia Lanzoni, Silvia Ferri, Marco Lenzi – 20 August 2010

Vered Gazit, Alexander Weymann, Eric Hartman, Brian N. Finck, Paul W. Hruz, Anatoly Tzekov, David A. Rudnick – 20 August 2010 – We previously reported that mice subjected to partial hepatectomy exhibit rapid development of hypoglycemia followed by transient accumulation of fat in the early regenerating liver. We also showed that disrupting these metabolic alterations results in impaired liver regeneration. The studies reported here were undertaken to further characterize and investigate the functional importance of changes in systemic adipose metabolism during normal liver regeneration.

James P. Nolan – 20 August 2010 – From the mid‐1950s, it was observed that liver injury by a variety of toxins greatly sensitized the host to the effects of administered lipopolysaccharide. In the nutritional cirrhosis of choline deficiency, and in acute toxic injury as well, the need for the presence of enteric endotoxin was demonstrated. The universality of this association was striking for almost all agents associated with liver injury.

Brian L. Pearlman, Carole Ehleben – 20 August 2010

Nicolas Goossens, Deepak Joshi, John O'Grady – 20 August 2010