Pediatric liver transplantation for primary sclerosing cholangitis

Tamir Miloh, Ravinder Anand, Wendy Yin, Miriam Vos, Nanda Kerkar, Estella Alonso, for the Studies of Pediatric Liver Transplantation Research Group – 19 April 2011 – Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease in children. The aim of this study was to determine the characteristics and outcomes of children with PSC who were listed for liver transplantation (LT).

Chest computed tomography is more likely to show latent tuberculosis foci than simple chest radiography in liver transplant candidates

Jiwon Lyu, Sung‐Gyu Lee, Shin Hwang, Sang‐Oh Lee, Oh‐Hyun Cho, Eun Jin Chae, Sang Do Lee, Woo Sung Kim, Dong Soon Kim, Tae Sun Shim – 19 April 2011 – Although the detection and treatment of latent tuberculosis infections (LTBIs) in transplant candidates are essential, current diagnostic methods for LTBIs are limited, especially in immunocompromised subjects. Pretransplant chest computed tomography (CT) may reveal more LTBI foci and thus predict the development of posttransplant tuberculosis (TB) more efficiently; however, this hypothesis has not yet been investigated.

Clinical utility of hepatitis B surface antigen quantitation in patients with chronic hepatitis B: A review

Yun‐Fan Liaw – 18 April 2011 – This clinically relevant review focuses on recent findings concerning hepatitis B surface antigen (HBsAg) quantitation in untreated patients and treated patients with chronic hepatitis B. Recent studies and emerging data have shown that both HBsAg and hepatitis B virus (HBV) DNA levels decline during the natural course of a chronic HBV infection; they are lowest in the inactive phase, which is also characterized by the highest HBsAg/HBV DNA ratio.

Schistosoma mansoni infection in the liver graft: The impact on donor and recipient outcomes after transplantation

Rodrigo Vincenzi, João Seda Neto, Eduardo A. Fonseca, Vincenzo Pugliese, Katia R. M. Leite, Marcel R. Benavides, Helry Lopes Cândido, Gilda Porta, Irene K. Miura, Renata Pugliese, Vera B. Danesi, Teresa C. Guimarães, Adriana Porta, Mario Kondo, Eduardo Carone, Paulo Chapchap – 18 April 2011 – The increasing number of transplants performed each year has led to the identification of unusual diseases in liver grafts from asymptomatic donors that were unrecognized before liver transplantation. Here we report our experience with patients who received liver grafts infected with schistosomiasis.

Liver‐specific loss of glucose‐regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice

Cheng Ji, Neil Kaplowitz, Mo Yin Lau, Eddy Kao, Lydia M. Petrovic, Amy S. Lee – 18 April 2011 – The endoplasmic reticulum (ER) chaperone protein glucose‐regulated protein 78 (GRP78)/binding immunoglobulin protein is a master regulator of ER homeostasis and stress responses, which have been implicated in the pathogenesis of metabolic disorders. By applying the locus of X‐over P1–cyclization recombination strategy, we generated mice with liver‐specific GRP78 loss.

Emergence of hepatitis B virus S gene mutants in patients experiencing hepatitis B surface antigen seroconversion after peginterferon therapy

Chao‐Wei Hsu, Chau‐Ting Yeh – 18 April 2011 – With anti–hepatitis B virus (anti‐HBV) therapy using peginterferon, the seroconversion of hepatitis B surface antigen (HBsAg), which is considered a cure of the disease, can be achieved in a small percentage of patients. Eight of 245 consecutive patients (3.27%) with chronic hepatitis B who received peginterferon therapy at our center achieved HBsAg seroclearance. Surprisingly, two of the eight patients remained viremic according to standard HBV DNA assays.

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