Pranoti Mandrekar, Aditya Ambade, Arlene Lim, Gyongyi Szabo, Donna Catalano – 2 December 2011 – The importance of chemokines in alcoholic liver injury has been implicated. The role of the chemokine, monocyte chemoattractant protein‐1 (MCP‐1), elevated in patients with alcoholic liver disease is not yet understood. Here, we evaluated the pathophysiological significance of MCP‐1 and its receptor, chemokine (C‐C motif) receptor 2 (CCR2), in alcoholic liver injury.

Keith D. Lindor, M.D. – 2 December 2011

Yang Liu, Shengdian Wang, Fusheng Wang, Dongling Li, Linghua Zheng, Pan Zheng – 2 December 2011

Ashish Goel, Banumathi Ramakrishna, Kadiyala Madhu, Uday Zachariah, Jeyamani Ramachandran, Shyamkumar N. Keshava, Elwyn Elias, Chundamannil E. Eapen – 2 December 2011

Chun‐Ming Wong, Carmen Chak‐Lui Wong, Joyce Man‐Fong Lee, Dorothy Ngo‐Yin Fan, Sandy Leung‐Kuen Au, Irene Oi‐Lin Ng – 2 December 2011 – Hepatocellular carcinoma (HCC) is a prevalent cancer with an extremely high mortality rate attributed to HCC metastasis, which is the major cause of tumor recurrence and organ failure. Presence of tumor thrombi in the portal veins (venous metastases) is a clinicopathological feature of metastatic HCCs.

Xiaohua Li, Qingchuan Zhao, Kaichun Wu, Daiming Fan – 2 December 2011

Gulam H. Syed, Aleem Siddiqui – 2 December 2011 – Hepatitis C virus (HCV) relies on host lipid metabolic pathways for its replication, assembly, secretion, and entry. HCV induces de novo lipogenesis, inhibits β‐oxidation, and lipoprotein export resulting in a lipid‐enriched cellular environment critical for its proliferation. We investigated the effects of a hypolipidemic agent, nordihydroguaiaretic acid (NDGA), on host lipid/fatty acid synthesis and HCV life cycle. NDGA negated the HCV‐induced alteration of host lipid homeostasis.

Kenneth E. Sherman, David L. Thomas, Raymond T. Chung – 2 December 2011 – Liver disease continues to represent a critical mediator of morbidity and mortality in those with human immunodeficiency virus (HIV) infection. The frequent presence and overlap of concomitant injurious processes, including hepatitis C virus and hepatitis B virus infections, hepatoxicity associated with antiretroviral therapeutic agents, alcohol, and other toxins, in the setting of immunosuppression lead to rapid fibrotic progression and early development of end‐stage liver disease.

Kathryn J. Fowler, Jeffrey J. Brown, Vamsi R. Narra – 2 December 2011 – This article is a review of magnetic resonance imaging (MRI) of incidental focal liver lesions. This review provides an overview of liver MRI protocol, diffusion‐weighted imaging, and contrast agents. Additionally, the most commonly encountered benign and malignant lesions are discussed with emphasis on imaging appearance and the diagnostic performance of MRI based on a review of the literature. (HEPATOLOGY 2011)

Angelo Sangiovanni, Massimo Colombo – 2 December 2011