Elizabeth J. Carey, D. Eric Steidley, Bashar A. Aqel, Thomas J. Byrne, Kristin L. Mekeel, Jorge Rakela, Hugo E. Vargas, David D. Douglas – 27 August 2010 – The 6‐minute walk distance (6MWD) is a simple test measuring global physical function. It is commonly used to predict mortality in patients with cardiac and pulmonary diseases, but it is also useful in assessing the functional status of patients with a variety of other medical conditions.

Tom Luedde – 27 August 2010 – Recurrent chromosomal aberrations are often observed in hepatocellular carcinoma (HCC), but little is known about the functional non‐coding sequences, particularly microRNAs (miRNAs), at the chromosomal breakpoints in HCC. Here we show that 22 miRNAs are often amplified or deleted in HCC. MicroRNA‐151 (miR‐151), a frequently amplified miRNA on 8q24.3, is correlated with intrahepatic metastasis of HCC.

Raymund R. Razonable – 26 August 2010

Alexander Dechêne, Jan‐Peter Sowa, Robert K. Gieseler, Christoph Jochum, Lars P. Bechmann, Amr El Fouly, Martin Schlattjan, Fuat Saner, Hideo A. Baba, Andreas Paul, Volker Dries, Margarethe Odenthal, Guido Gerken, Scott L. Friedman, Ali Canbay – 26 August 2010 – Acute liver failure (ALF) is associated with massive short‐term cell death, whereas chronic liver injury is accompanied by continuous cell death. Hepatic stellate cells (HSCs) contribute to tissue repair and liver fibrosis in chronic liver injury, although their role in ALF remains unexplained.

Marina Núñez – 26 August 2010 – Highly active antiretroviral therapy (HAART)‐related hepatotoxicity complicates the management of patients infected with human immunodeficiency virus (HIV), increases medical costs, alters the prescription patterns, and affects the guideline recommendations.

Ting‐Tsung Chang, Yun‐Fan Liaw, Shun‐Sheng Wu, Eugene Schiff, Kwang‐Hyub Han, Ching‐Lung Lai, Rifaat Safadi, Samuel S. Lee, Waldemar Halota, Zachary Goodman, Yun‐Chan Chi, Hui Zhang, Robert Hindes, Uchenna Iloeje, Suzanne Beebe, Bruce Kreter – 26 August 2010 – One year of treatment with entecavir (0.5 mg daily) in nucleoside‐naive patients with hepatitis B e antigen (HBeAg)‐positive or HBeAg‐negative chronic hepatitis B (CHB) resulted in significantly improved liver histology and virological and biochemical endpoints in comparison with lamivudine.

Nazim Ghouri, David Preiss, Naveed Sattar – 26 August 2010 – In recent years, a strong link has been established between nonalcoholic fatty liver disease (NAFLD) and the pathogenesis of type 2 diabetes mellitus. The potential role of NAFLD in cardiovascular disease (CVD) has also attracted interest. Published studies have tended to use biochemical and imaging surrogate markers of NAFLD, such as elevated gamma glutamyl transpeptidase (GGT) and alanine aminotransferase (ALT) and fatty liver on ultrasound, when investigating associations with incident CVD events.

Ana Lleo, Christopher L. Bowlus, Guo‐Xiang Yang, Pietro Invernizzi, Mauro Podda, Judy Van de Water, Aftab A. Ansari, Ross L. Coppel, Howard J. Worman, Gregory J. Gores, M. Eric Gershwin – 26 August 2010 – Our understanding of primary biliary cirrhosis (PBC) has been significantly enhanced by the rigorous dissection of the multilineage T and B cell response against the immunodominant mitochondrial autoantigen, the E2 component of the pyruvate dehydrogenase complex (PDC‐E2). PDC‐E2 is a ubiquitous protein present in mitochondria of nucleated cells.

Tatsuya Tazaki, Takaaki Sasaki, Kenta Uto, Norimasa Yamasaki, Satoshi Tashiro, Ryuichi Sakai, Minoru Tanaka, Hideaki Oda, Zen‐Ichiro Honda, Hiroaki Honda – 26 August 2010 – p130Cas, Crk‐associated substrate (Cas), is an adaptor/scaffold protein that plays a central role in actin cytoskeletal reorganization. We previously showed that mice in which Cas was deleted (Cas−/−) died in utero because of early cardiovascular maldevelopment.

Wei Ding, Hanning You, Hien Dang, Francis LeBlanc, Vivian Galicia, Shelly C. Lu, Bangyan Stiles, C. Bart Rountree – 26 August 2010 – Epithelial‐to‐mesenchymal transition (EMT) is predicted to play a critical role in metastatic disease in hepatocellular carcinoma. In this study, we used a novel murine model of EMT to elucidate a mechanism of tumor progression and metastasis. A total of 2 × 106 liver cells isolated from Ptenloxp/loxp/Alb‐Cre+ mice, expanded from a single CD133+CD45− cell clone, passage 0 (P0), were sequentially transplanted to obtain two passages of tumor cells, P1 and P2.