Impact of obesity on children undergoing liver transplantation

André A. S. Dick, James D. Perkins, Austin L. Spitzer, Oliver B. Lao, Patrick J. Healey, Jorge D. Reyes – 27 August 2010 – Controversies exist with respect to the mortality of patients undergoing liver transplantation at the extremes of the body mass index (BMI). For pediatric liver transplantation, weight is usually the only factor considered in survival analysis. A review of the United Network for Organ Sharing database (1987‐2007) revealed 9701 pediatric patients (<18 years old) who underwent primary liver transplantation.

Post–liver transplant cholestatic hepatitis C: A systematic review of clinical and pathological findings and application of consensus criteria

Tarun K. Narang, Will Ahrens, Mark W. Russo – 27 August 2010 – Liver transplantation is currently the only definitive modality for the treatment of end‐stage liver disease due to chronic hepatitis C. However, recurrent hepatitis C after liver transplantation is nearly universal. Cirrhosis may develop in 20% of recipients within 5 years, and recurrent hepatitis C may lead to graft failure, retransplantation, and even death.

Hepatitis C recurrence is not adversely affected by the use of donation after cardiac death liver allografts

Ran Tao, Kristine Ruppert, Ruy J. Cruz, Shahid M. Malik, Obaid Shaikh, Jawad Ahmad, Andrea DiMartini, Abhinav Humar, Paulo A. Fontes, Michael E. de Vera – 27 August 2010 – Many factors can worsen a recurrent hepatitis C virus (HCV) infection after liver transplantation (LT). We sought to determine whether the use of donation after cardiac death (DCD) livers affects HCV recurrence. From January 2000 to June 2008, 37 HCV patients underwent LT with DCD allografts.

A common variant in the patatin‐like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents

Nicola Santoro, Romy Kursawe, Ebe D'Adamo, Daniel J. Dykas, Clarence K. Zhang, Allen E. Bale, Anna M. Calí, Deepak Narayan, Melissa M. Shaw, Bridget Pierpont, Mary Savoye, Derek Lartaud, Samuel Eldrich, Samuel W. Cushman, Hongyu Zhao, Gerald I. Shulman, Sonia Caprio – 27 August 2010 – The genetic factors associated with susceptibility to nonalcoholic fatty liver disease (NAFLD) in pediatric obesity remain largely unknown.

Six‐minute walk distance predicts mortality in liver transplant candidates

Elizabeth J. Carey, D. Eric Steidley, Bashar A. Aqel, Thomas J. Byrne, Kristin L. Mekeel, Jorge Rakela, Hugo E. Vargas, David D. Douglas – 27 August 2010 – The 6‐minute walk distance (6MWD) is a simple test measuring global physical function. It is commonly used to predict mortality in patients with cardiac and pulmonary diseases, but it is also useful in assessing the functional status of patients with a variety of other medical conditions.

MicroRNA‐151 and its hosting gene FAK (focal adhesion kinase) regulate tumor cell migration and spreading of hepatocellular carcinoma

Tom Luedde – 27 August 2010 – Recurrent chromosomal aberrations are often observed in hepatocellular carcinoma (HCC), but little is known about the functional non‐coding sequences, particularly microRNAs (miRNAs), at the chromosomal breakpoints in HCC. Here we show that 22 miRNAs are often amplified or deleted in HCC. MicroRNA‐151 (miR‐151), a frequently amplified miRNA on 8q24.3, is correlated with intrahepatic metastasis of HCC.

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