Inhibition of inducible nitric oxide synthase prevents graft injury after transplantation of livers from rats after cardiac death

Yanjun Shi, Hasibur Rehman, Gary L. Wright, Zhi Zhong – 28 October 2010 – This study investigated the roles of inducible nitric oxide synthase (iNOS) in the failure of rat liver grafts from cardiac death donors (GCDD). Livers were explanted after 30‐minute aorta clamping and implanted after 4‐hour storage in University of Wisconsin solution. The iNOS expression increased slightly in grafts from non–cardiac death donors (GNCDD) but markedly in GCDD.

Differences in portal hemodynamics between whole liver transplantation and living donor liver transplantation

Shui‐Ming Jiang, Qi‐Shun Zhang, Guang‐Wen Zhou, Shi‐Feng Huang, Hai‐Ming Lu, Cheng‐Hong Peng – 28 October 2010 – The aim of this study was to investigate the differences in portal hemodynamics between whole liver transplantation and living donor liver transplantation (LDLT). Twenty patients who underwent LDLT (the L group) and 42 patients who underwent whole liver transplantation (the W group) were enrolled, and colored Doppler ultrasonography was performed preoperatively and on postoperative days (PODs) 1, 3, 5, 7, 30, and 90.

Differential effects of plasma and red blood cell transfusions on acute lung injury and infection risk following liver transplantation

Alexander B. Benson, James R. Burton, Gregory L. Austin, Scott W. Biggins, Michael A. Zimmerman, Igal Kam, Susan Mandell, Christopher C. Silliman, Hugo Rosen, Marc Moss – 27 October 2010 – Patients with chronic liver disease have an increased risk of developing transfusion‐related acute lung injury (TRALI) from plasma‐containing blood products. Similarly, red blood cell transfusions have been associated with postoperative and nosocomial infections in surgical and critical care populations.

Native macrophages genetically modified to express heme oxygenase 1 protect rat liver transplants from ischemia/reperfusion injury

Xiu‐Da Shen, Bibo Ke, Yoichiro Uchida, Haofeng Ji, Feng Gao, Yuan Zhai, Ronald W. Busuttil, Jerzy W. Kupiec‐Weglinski – 27 October 2010 – We investigated whether native macrophages overexpressing heme oxygenase 1 (HO‐1) could protect rat orthotopic liver transplant (OLT) against cold ischemia/reperfusion injury (IRI). Livers from Sprague‐Dawley rats were stored at 4°C in University of Wisconsin solution for 24 hours, and then they were transplanted into syngeneic recipients.

Hepatitis C pharmacogenetics: State of the art in 2010

Nezam H. Afdhal, John G. McHutchison, Stefan Zeuzem, Alessandra Mangia, Jean‐Michel Pawlotsky, Jeffrey S. Murray, Kevin V. Shianna, Yasuhito Tanaka, David L. Thomas, David R. Booth, David B. Goldstein, for the Pharmacogenetics and Hepatitis C Meeting Participants – 26 October 2010 – In 2009, a correlated set of polymorphisms in the region of the interleukin‐28B (IL28B) gene were associated with clearance of genotype 1 hepatitis C virus (HCV) in patients treated with pegylated interferon‐alfa and ribavirin.

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