School outcomes in children registered in the studies for pediatric liver transplant (SPLIT) consortium

Susan M. Gilmour, Lisa G. Sorensen, Ravinder Anand, Wanrong Yin, Estella M. Alonso – 30 August 2010 – School performance is an important aspect of functional outcomes for pediatric liver transplant (LT) recipients. This longitudinal analysis conducted through the Studies of Pediatric Liver Transplantation (SPLIT) research consortium examines several indicators of school function in these patients. A total of 39 centers participated in data collection using a semistructured questionnaire designed specifically for this study.

Recurrent liver failure in a 25‐year‐old female

Jefrey Salek, Janice Byrne, Terry Box, Nicola Longo, Norman Sussman – 30 August 2010 – Acute liver failure (ALF) is defined as severe and sudden liver dysfunction leading to coagulopathy and encephalopathy in a previously healthy person without preexisting liver disease. Almost half of adult cases of ALF are due to acetaminophen toxicity, with 21% labeled indeterminate or other. We present a patient with a second episode of ALF, both episodes being initiated by catabolic stress.

Tailored telescopic reconstruction of the bile duct in living donor liver transplantation

Seong Hoon Kim, Kwang‐Woong Lee, Young‐Kyu Kim, Seong Yeon Cho, Sung‐Sik Han, Sang‐Jae Park – 30 August 2010 – Duct‐to‐duct reconstruction (DDR) of the bile duct has recently become the preferred choice in living donor liver transplantation (LDLT), but biliary complications still remain the most common cause of morbidity.

Primary sclerosing cholangitis in genetically diverse populations listed for liver transplantation: Unique clinical and human leukocyte antigen associations

Christopher L. Bowlus, Chin‐Shang Li, Tom H. Karlsen, Benedicte A. Lie, Carlo Selmi – 27 August 2010 – Primary sclerosing cholangitis (PSC) is well characterized in European populations. We aimed to characterize clinical characteristics and human leukocyte antigen (HLA) associations in a population of European American, Hispanic, and African American PSC patients listed for liver transplantation (LT).

Occult hepatitis B virus infection of donor and recipient origin after liver transplantation despite nucleoside analogue prophylaxis

Cindy Ka Yee Cheung, Chung Mau Lo, Kwan Man, George Ka Kit Lau – 27 August 2010 – Liver grafts from donors positive for antibody to hepatitis B core antigen (anti‐HBc) may be used for transplantation in patients with hepatitis B virus (HBV)–related liver disease, and an occult HBV infection may develop from either source. Liver biopsy was performed for 31 patients who remained seronegative for hepatitis B surface antigen for a median of 44.5 months (range = 13.6‐126.4 months) and received nucleoside analogue prophylaxis post‐transplant.

Identification of new donor variables associated with graft survival in a single‐center liver transplant cohort

Otmane Nafidi, Denis Marleau, André Roy, Marc Bilodeau – 27 August 2010 – We currently face the more widespread use of marginal livers for organ transplantation. Therefore, it is imperative to adequately identify the factors affecting early and late graft survival in that setting. The objective of this study was to determine the donor variables associated with graft survival in the liver transplant program of the University of Montreal. We retrospectively studied the survival of 634 grafts transplanted into 634 recipients between 1990 and 2008.

Long‐term survival after 67 hours of anhepatic state due to primary liver allograft nonfunction

Harendra Arora, Janine Thekkekandam, Leora Tesche, Raeshell Sweeting, David A. Gerber, Paul H. Hayashi, Kenneth Andreoni, Tomasz Kozlowski – 27 August 2010 – Primary liver allograft nonfunction immediately after transplantation poses a life‐threatening situation for the recipient. Emergency retransplantation may not be immediately possible due to organ unavailability. Total hepatectomy with temporary portacaval shunt has been described as a bridge to retransplantation when the presence of the graft appears to be harming the recipient.

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