Interferon induced protein 10 remains a useful biomarker of treatment failure in patients stratified for the interleukin‐28B rs12979860 Haplotype

Matthew L. Albert, Armanda Casrouge, Stéphane Chevaliez, Christophe Hézode, Isabelle Rosa, Philippe Renard, Vincent Mallet, Arnaud Fontanet, Jean‐Michel Pawlotsky, Stanislas Pol – 26 October 2010

Quantitation of pretreatment serum interferon‐γ–inducible protein‐10 improves the predictive value of an IL28B gene polymorphism for hepatitis C treatment response

Jama M. Darling, Jeroen Aerssens, Gregory Fanning, John G. McHutchison, David B. Goldstein, Alexander J. Thompson, Kevin V. Shianna, Nezam H. Afdhal, Michael L. Hudson, Charles D. Howell, Willem Talloen, Jacques Bollekens, Mieke De Wit, Annick Scholliers, Michael W. Fried – 26 October 2010 – Polymorphisms of the IL28B gene are highly associated with sustained virological response (SVR) in patients with chronic hepatitis C treated with peginterferon and ribavirin. Quantitation of interferon‐γ–inducible protein‐10 (IP‐10) may also differentiate antiviral response.

Digital image analysis of liver collagen predicts clinical outcome of recurrent hepatitis C Virus 1 year after liver transplantation

Pinelopi Manousou, Amar P. Dhillon, Graziela Isgro, Vincenza Calvaruso, T.V. Luong, Emmanuel Tsochatzis, E. Xirouchakis, G. Kalambokis, Timothy J. Cross, N. Rolando, James O'Beirne, David Patch, D. Thornburn, Andrew K. Burroughs – 21 October 2010 – Clinical outcomes of recurrent hepatitis C virus after liver transplantation are difficult to predict. We evaluated collagen proportionate area (CPA), a quantitative histological index, at 1 year with respect to the first episode of clinical decompensation.

Domino versus deceased donor liver transplantation: Association with early graft function and perioperative bleeding

Miguel Bispo, Paulo Marcelino, Hugo Pinto Marques, Américo Martins, Rui Perdigoto, Maria João Aguiar, Luís Mourão, Eduardo Barroso – 21 October 2010 – This study sought to evaluate the potential impact of domino liver transplantation (DLT) on initial graft function and early postoperative outcome in patients with cirrhosis in a Portuguese liver transplantation center.

Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct–ligated rats and human hepatic cells

Hongwei He, Albert Mennone, James L. Boyer, Shi‐Ying Cai – 21 October 2010 – Cholestasis leads to liver cell death, fibrosis, cirrhosis, and eventually liver failure. Despite limited benefits, ursodeoxycholic acid (UDCA) is the only Food and Drug Administration–approved treatment for cholestatic disorders. Retinoic acid (RA) is a ligand for nuclear receptors that modulate bile salt homeostasis. RA also possesses immunomodulatory effects and is used to treat acute promyelocytic leukemia and inflammatory disorders such as psoriasis, acne, and rheumatoid arthritis.

Pharmacokinetics for once‐daily versus twice‐daily tacrolimus formulations in de novo liver transplantation: A randomized, open‐label trial

Lutz Fischer, Pavel Trunečka, Bruno Gridelli, Andre Roy, Alessandro Vitale, Andrés Valdivieso, Evaristo Varo, Daniel Seehofer, Stephen Lynch, Didier Samuel, Bo‐Goran Ericzon, Karim Boudjema, Carmen Karpf, Nasrullah Undre – 21 October 2010 – Tacrolimus, a cornerstone immunosuppressant, is available as a twice‐daily formulation (tacrolimus bid). A once‐daily prolonged‐release formulation (tacrolimus qd) has been developed.

Strong influence of human leukocyte antigen (HLA)‐DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population

Xiuchan Guo, Yong Zhang, Ji Li, Jingchen Ma, Zuli Wei, Wenjie Tan, Stephen J. O'Brien – 20 October 2010 – Chronic hepatitis B virus (HBV) infection is a major health issue, especially in Asia. A recent genome‐wide association study (GWAS) implicated genetic variants in the human leukocyte antigen (HLA)‐DP locus associated with chronic hepatitis B in Japanese and Thai populations.

Sterol transporter adenosine triphosphate–binding cassette transporter G8, gallstones, and biliary cancer in 62,000 individuals from the general population

Stefan Stender, Ruth Frikke‐Schmidt, Børge G. Nordestgaard, Anne Tybjærg‐Hansen – 20 October 2010 – Gallstone disease, a risk factor for biliary cancer, has a strong heritable component, but the underlying genes are largely unknown.

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