Fei Qi, Jianbo Song, Hanshuo Yang, Wei Gao, Ning‐ai Liu, Bo Zhang, Shuo Lin – 31 August 2010 – The matrix metalloproteinase (MMP) family of proteins degrades extracellular matrix (ECM) components as well as processes cytokines and growth factors. MMPs are involved in regulating ECM homeostasis in both normal physiology and disease pathophysiology. Here we report the critical roles of mmp23b in normal zebrafish liver development.

Anisha A. Gupte, Joey Z. Liu, Yuelan Ren, Laurie J. Minze, Jessica R. Wiles, Alan R. Collins, Christopher J. Lyon, Domenico Pratico, Milton J. Finegold, Stephen T. Wong, Paul Webb, John D. Baxter, David D. Moore, Willa A. Hsueh – 31 August 2010 – Nonalcoholic fatty liver disease (NAFLD) is a common complication of obesity that can progress to nonalcoholic steatohepatitis (NASH), a serious liver pathology that can advance to cirrhosis. The mechanisms responsible for NAFLD progression to NASH remain unclear.

Yu‐Hua Xue, Xiao‐Fei Zhang, Qiong‐Zhu Dong, Jian Sun, Chun Dai, Hai‐Jun Zhou, Ning Ren, Hu‐Liang Jia, Qin‐Hai Ye, Lun‐Xiu Qin – 31 August 2010 – We previously identified osteopontin (OPN) as a promoter and thus a potential therapeutic target for hepatocellular carcinoma (HCC) metastasis. The serine protease thrombin interacts with OPN and can modify its biological activity.

Benjamin Goeppert, Peter Schmezer, Céline Dutruel, Christopher Oakes, Marcus Renner, Marco Breinig, Arne Warth, Monika Nadja Vogel, Michel Mittelbronn, Arianeb Mehrabi, Georg Gdynia, Roland Penzel, Thomas Longerich, Kai Breuhahn, Odilia Popanda, Christoph Plass, Peter Schirmacher, Michael André Kern – 31 August 2010 – The A kinase anchor protein 12 (AKAP12) is a central mediator of protein kinase A and protein kinase C signaling.

Josh Levitsky, Kavitha Thudi, Michael G. Ison, Edward Wang, Michael Abecassis – 31 August 2010 – Limited data exist for the use of alemtuzumab (AL) induction in liver transplantation (LT) recipients. We compared the outcomes of hepatitis C virus–negative LT recipients who received AL induction followed by tacrolimus and mycophenolate mofetil without steroids to cohort who received no AL induction, tacrolimus, and a steroid taper. Fifty‐five AL‐induced recipients were compared to 85 non–AL‐induced recipients with similar characteristics.

Victor W. Xia, Jonathan K. Ho, Hamid Nourmand, Christopher Wray, Ronald W. Busuttil, Randolph H. Steadman – 31 August 2010 – Even though numerous cases of massive thromboemboli have been reported in the literature, intracardiac thromboemboli (ICTs) incidentally found during orthotopic liver transplantation (OLT) have not been examined. In this study, we retrospectively examined the incidence, risk factors, and management of incidental ICTs during OLT.

Camille Nelson Kotton, Rocío M Hurtado – 31 August 2010

Raymond T. Chung, Fred F. Poordad, Tarek Hassanein, Xiaolei Zhou, Ellen Lentz, Avinash Prabhakar, Adrian M. Di Bisceglie – 31 August 2010 – Patients receiving therapy for chronic hepatitis C virus (HCV) infection frequently experience cytopenias and weight loss. We retrospectively assessed the pharmacodynamic effects of pegylated interferon (PEG‐IFN) alfa‐2a and ribavirin by evaluating the relationship between changes in hematologic parameters, body weight, and virologic response.

Seong Hoon Kim, Kwang‐Woong Lee, Young‐Kyu Kim, Seong Yeon Cho, Sung‐Sik Han, Sang‐Jae Park – 30 August 2010 – Duct‐to‐duct reconstruction (DDR) of the bile duct has recently become the preferred choice in living donor liver transplantation (LDLT), but biliary complications still remain the most common cause of morbidity.

Jefrey Salek, Janice Byrne, Terry Box, Nicola Longo, Norman Sussman – 30 August 2010 – Acute liver failure (ALF) is defined as severe and sudden liver dysfunction leading to coagulopathy and encephalopathy in a previously healthy person without preexisting liver disease. Almost half of adult cases of ALF are due to acetaminophen toxicity, with 21% labeled indeterminate or other. We present a patient with a second episode of ALF, both episodes being initiated by catabolic stress.