Geert A. A. Nibourg, Maarten T. Huisman, Tessa V. van der Hoeven, Thomas M. van Gulik, Robert A. F. M. Chamuleau, Ruurdtje Hoekstra – 30 August 2010 – To bridge patients with acute liver failure to transplantation or liver regeneration, a bioartificial liver (BAL) is urgently needed. A BAL consists of an extracorporeal bioreactor loaded with a bioactive mass that would preferably be of human origin and display high hepatic functionality, including detoxification. The human hepatoma cell line HepG2 exhibits many hepatic functions, but its detoxification function is low.

Yixin Chen, Hongchao Zhou, Aaron L. Sarver, Yan Zeng, Jayanta Roy‐Chowdhury, Clifford J. Steer, M. Behnan Sahin – 30 August 2010 – We recently reported the isolation and characterization of a novel population of progenitor cells called liver‐derived progenitor cells (LDPCs), which could differentiate into functional hepatocytes in vitro. However, our original studies resulted in relatively low and variable hepatic differentiation efficiency without validation of in vivo potential of LDPCs.

Koichiro Uchida, Masahiko Taniguchi, Tsuyoshi Shimamura, Tomomi Suzuki, Kenichiro Yamashita, Minoru Ota, Toshiya Kamiyama, Michiaki Matsushita, Hiroyuki Furukawa, Satoru Todo – 30 August 2010 – Because hepatic vasculatures exhibit variations, a preoperative evaluation of the vascular anatomy and an estimation of the volume of the liver graft are essential for successful adult living donor liver transplantation. Using 3‐dimensional (3D) computed tomography (CT), we analyzed the volumetric and anatomical relationship of the hepatic vasculatures of liver grafts.

M. Amine Zaouali, Susagna Padrissa‐Altés, Ismail Ben Mosbah, Izabel Alfany‐Fernandez, Marta Massip‐Salcedo, Araní Casillas‐Ramirez, María Bintanel‐Morcillo, Olivier Boillot, Anna Serafin, Antoni Rimola, Juan Rodés, Joan Roselló‐Catafau, Carmen Peralta – 30 August 2010 – This study examined the effects of epidermal growth factor (EGF) and insulin‐like growth factor‐I (IGF‐I) supplementation to University of Wisconsin solution (UW) in steatotic and nonsteatotic livers during cold storage.

Hideaki Uchiyama, Ken Shirabe, Akinobu Taketomi, Yuji Soejima, Mizuki Ninomiya, Hiroto Kayashima, Toru Ikegami, Yoshihiko Maehara – 30 August 2010 – Graft hepatic arteries (HAs) are usually reconstructed with a recipient HA branch (anatomical HA reconstruction) in living donor liver transplantation (LDLT). Surgeons often encounter difficulties in reconstructing HAs, particularly when a recipient artery other than an HA branch must be used; this is known as extra‐anatomical HA reconstruction.

Sumeet K. Asrani, W. Ray Kim, Patrick S. Kamath – 30 August 2010

Jerzy W. Kupiec‐Weglinski, Cecilia M. Freitas – 30 August 2010

Ricky H. Bhogal, Simon C. Afford – 30 August 2010

Susan M. Gilmour, Lisa G. Sorensen, Ravinder Anand, Wanrong Yin, Estella M. Alonso – 30 August 2010 – School performance is an important aspect of functional outcomes for pediatric liver transplant (LT) recipients. This longitudinal analysis conducted through the Studies of Pediatric Liver Transplantation (SPLIT) research consortium examines several indicators of school function in these patients. A total of 39 centers participated in data collection using a semistructured questionnaire designed specifically for this study.

Jefrey Salek, Janice Byrne, Terry Box, Nicola Longo, Norman Sussman – 30 August 2010 – Acute liver failure (ALF) is defined as severe and sudden liver dysfunction leading to coagulopathy and encephalopathy in a previously healthy person without preexisting liver disease. Almost half of adult cases of ALF are due to acetaminophen toxicity, with 21% labeled indeterminate or other. We present a patient with a second episode of ALF, both episodes being initiated by catabolic stress.