Small‐duct sclerosing cholangitis associated with Schistosoma mansoni
Catherine H. McCrann, James L. Boyer – 7 September 2010
Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells
Mei‐Chuan Chen, Chun‐Han Chen, Hsiao‐Ching Chuang, Samuel K. Kulp, Che‐Ming Teng, Ching‐Shih Chen – 7 September 2010 – Histone deacetylase (HDAC) inhibitors exhibit a unique ability to degrade topoisomerase (topo)IIα in hepatocellular carcinoma (HCC) cells, which contrasts with the effect of topoII‐targeted drugs on topoIIβ degradation. This selective degradation might foster novel strategies for HCC treatment in light of the correlation of topoIIα overexpression with the aggressive tumor phenotype and chemoresistance.
Observed and calculated interleukin‐28B genotype frequencies in hepatitis C virus infection
Magnus Lindh, Martin Lagging, Gunnar Norkrans, Kristoffer Hellstrand – 7 September 2010
The next step for taribavirin
Paul Y. Kwo, Rakesh Vinayek – 7 September 2010
Early determination of hepatitis C virus RNA may help to decide the duration of therapy for chronic hepatitis C virus genotype 2/3 infection
Martin Lagging, Åsa Alsiö, Nina Langeland, Court Pedersen, Martti Färkkilä, Mads Rauning Buhl, Kristine Mørch, Kristoffer Hellstrand, Gunnar Norkrans – 7 September 2010
On the mechanism of action of vitamin E for nonalcoholic steatohepatitis
Hong‐Fang Ji, Liang Shen – 1 September 2010
Reply:
Michael P. Manns, Albert J. Czaja, James D. Gorham, Edward L. Krawitt, Giorgina Mieli‐Vergani, Diego Vergani, John M. Vierling – 1 September 2010
Tenofovir disoproxil fumarate (TDF), emtricitabine/TDF, and entecavir in patients with decompensated chronic hepatitis B liver disease
Yun‐Fan Liaw, I‐Shyan Sheen, Chuan‐Mo Lee, Ulus Salih Akarca, George V. Papatheodoridis, Florence Suet‐Hing Wong, Ting‐Tsung Chang, Andrzej Horban, Chia Wang, Peter Kwan, Maria Buti, Martin Prieto, Thomas Berg, Kathryn Kitrinos, Ken Peschell, Elsa Mondou, David Frederick, Franck Rousseau, Eugene R. Schiff – 1 September 2010 – Data are limited on the safety and effectiveness of oral antivirals other than lamivudine and adefovir dipivoxil for treatment of chronic hepatitis B (CHB) in patients with decompensated liver disease.
B7‐H4 mediates inhibition of T cell responses by activated murine hepatic stellate cells
Raghavan Chinnadurai, Arash Grakoui – 1 September 2010 – Liver fibrosis is mediated by the transformation of hepatic stellate cells (HSC) from a quiescent to an activated state. To understand the role of HSC in liver immunity, we investigated the effect of this transition on T cell stimulation in vitro. Unlike quiescent HSC, activated HSC did not induce proliferation of antigen‐specific T cells. Phenotypic analysis of quiescent and activated HSC revealed that activated HSC expressed the coinhibitory molecule B7‐H4.
Unconjugated bile salts shuttle through hepatocyte peroxisomes for taurine conjugation
Krzysztof P. Rembacz, Jannes Woudenberg, Mark Hoekstra, Elles Z. Jonkers, Fiona A.J. van den Heuvel, Manon Buist‐Homan, Titia E. Woudenberg‐Vrenken, Jana Rohacova, M. Luisa Marin, Miguel A. Miranda, Han Moshage, Frans Stellaard, Klaas Nico Faber – 1 September 2010 – Bile acid‐CoA:amino acid N‐acyltransferase (BAAT) conjugates bile salts to glycine or taurine, which is the final step in bile salt biosynthesis. In addition, BAAT is required for reconjugation of bile salts in the enterohepatic circulation.