Bacterial translocation attenuates the systemic hemodynamic improvement produced by terlipressin in patients with cirrhosis
Georgios N. Kalambokis, Athanasia Mouzaki, Maria Rodi, Konstantinos Pappas, Epameinondas V. Tsianos – 12 May 2011
Obesity is an independent risk factor for clinical decompensation in patients with cirrhosis
Annalisa Berzigotti, Guadalupe Garcia‐Tsao, Jaime Bosch, Norman D. Grace, Andrew K. Burroughs, Rosa Morillas, Angels Escorsell, Juan Carlos Garcia‐Pagan, David Patch, Daniel S. Matloff, Roberto J. Groszmann, the Portal Hypertension Collaborative Group – 12 May 2011 – Obesity is associated with an aggressive course in chronic viral hepatitis; however, its impact in the development of clinical decompensation (CD) in patients with established cirrhosis is uncertain.
Hyperhomocysteinemia from trimethylation of hepatic phosphatidylethanolamine during cholesterol cholelithogenesis in inbred mice
Ji Zhang, Diane E. Handy, Yufang Wang, Guylaine Bouchard, Jacob Selhub, Joseph Loscalzo, Martin C. Carey – 12 May 2011 – Because hyperhomocysteinemia can occur in cholesterol gallstone disease, we hypothesized that this may result from trimethylation of phosphatidylethanolamine (PE), which partakes in biliary phosphatidylcholine (PC) hypersecretion during cholesterol cholelithogenesis.
Hepatitis C virus therapeutics: Editing enzymes promising therapeutic targets?
Anna Alisi, Sara Tomaselli, Clara Balsano, Angela Gallo – 11 May 2011
Carcinogen‐induced hepatic tumors in KLF6+/− mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation
Mirko Tarocchi, Rebekka Hannivoort, Yujin Hoshida, Ursula E. Lee, Diana Vetter, Goutham Narla, Augusto Villanueva, Moshe Oren, Josep M. Llovet, Scott L. Friedman – 11 May 2011 – Inactivation of KLF6 is common in hepatocellular carcinoma (HCC) associated with hepatitis C virus (HCV) infection, thereby abrogating its normal antiproliferative activity in liver cells. The aim of the study was to evaluate the impact of KLF6 depletion on human HCC and experimental hepatocarcinogenesis in vivo.
Mechanisms by which TLR4 and endotoxin promote hepatocellular carcinoma require further investigation
Ali Mencin, Geum‐Youn Gwak, Robert F. Schwabe – 11 May 2011
Liver transplantation in human immunodeficiency virus‐positive patients
Deepak Joshi, John O'Grady, Chris Taylor, Nigel Heaton, Kosh Agarwal – 11 May 2011 – With the successful introduction of combined antiretroviral therapy (cART), human immunodeficiency virus (HIV) is now regarded as a chronic illness with excellent long‐term outcomes. However, chronic exposure to viral etiologies (ie, chronic hepatitis B and hepatitis C) and drug‐induced toxicity secondary to cART have resulted in increasing rates of mortality and morbidity due to end‐stage liver disease.
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Anna S. Lok, James E. Everhart – 11 May 2011
Toll‐like receptor 2 polymorphism and gram‐positive bacterial infections after liver transplantation
Sang‐Oh Lee, Robert A. Brown, Seung H. Kang, Rima C. Abdel‐Massih, Raymund R. Razonable – 11 May 2011 – Toll‐like receptor 2 (TLR2) is an immune sensor for gram‐positive bacterial cell wall components. Single‐nucleotide polymorphisms (SNPs) in the TLR2 gene that impair its function may, therefore, influence the risk and outcomes of gram‐positive bacterial infections.