The MAP3K TAK1: A chock block to liver cancer formation
Yann Malato, Holger Willenbring – 28 September 2010
The immunosuppressive pipeline: Meeting unmet needs in liver transplantation
Nazia Selzner, David R. Grant, Itay Shalev, Gary A. Levy – 28 September 2010 – Liver transplantation is now recognized as the treatment of choice for end‐stage liver failure. Its success can be attributed largely to the generation of selective immunosuppressive agents, which have resulted in a dramatic reduction in the incidence of acute rejection and improvements in the short‐ and long‐term outcomes of patients.
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Doris Wagner, Daniela Kniepeiss, Florian Iberer, Astrid Fahrleitner‐Pammer, Peter Kornprat, Karlheinz Tscheliessnigg – 28 September 2010
Meeting Report of the 16th Annual International Congress of the International Liver Transplantation Society
Josh Levitsky, Olaf Guckelberger – 28 September 2010
Lineage restriction of human hepatic stem cells to mature fates is made efficient by tissue‐specific biomatrix scaffolds
Yunfang Wang, Cai‐Bin Cui, Mitsuo Yamauchi, Patricia Miguez, Marsha Roach, Richard Malavarca, M. Joseph Costello, Vincenzo Cardinale, Eliane Wauthier, Claire Barbier, David A. Gerber, Domenico Alvaro, Lola M. Reid – 24 September 2010 – Current protocols for differentiation of stem cells make use of multiple treatments of soluble signals and/or matrix factors and result typically in partial differentiation to mature cells with under‐ or overexpression of adult tissue‐specific genes.
Incidence and risk factors of hepatocellular carcinoma in patients with primary biliary cirrhosis
Carole Macaron, Ibrahim A. Hanouneh, Nizar N. Zein – 24 September 2010
Antihepatoma activity of chaetocin due to deregulated splicing of hypoxia‐inducible factor 1α pre‐mRNA in mice and in vitro
Yoon‐Mi Lee, Ji‐Hong Lim, Haejin Yoon, Yang‐Sook Chun, Jong‐Wan Park – 24 September 2010 – Chaetocin, an antibiotic produced by Chaetomium species fungi, was recently found to have antimyeloma activity. Here we examined whether chaetocin has anticancer activities against solid tumors. Chaetocin inhibited the growth of mouse and human hepatoma grafts in nude mice. Immunohistochemical analyses revealed that chaetocin inhibits hypoxia‐inducible factor‐1α (HIF‐1α) expression and vessel formation in the tumors.
Activation of the endotoxin/toll‐like receptor 4 pathway: The way to go from nonalcoholic steatohepatitis up to hepatocellular carcinoma
Anna Alisi, Nadia Panera, Clara Balsano, Valerio Nobili – 24 September 2010
Open access journals: Why are we not there yet? (!)
Gregory J. Gores – 24 September 2010
Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning
Kuok Teong Ong, Mara T. Mashek, So Young Bu, Andrew S. Greenberg, Douglas G. Mashek – 24 September 2010 – Despite advances in our understanding of the ways in which nutrient oversupply and triacylglycerol (TAG) anabolism contribute to hepatic steatosis, little is known about the lipases responsible for regulating hepatic TAG turnover. Recent studies have identified adipose triglyceride lipase (ATGL) as a major lipase in adipose tissue, although its role in the liver is largely unknown. Thus, we tested the contribution of ATGL to hepatic lipid metabolism and signaling.