CXC chemokine receptor‐1 is expressed by hepatocytes and regulates liver recovery after hepatic ischemia/reperfusion injury

Callisia Clarke, Satoshi Kuboki, Nozomu Sakai, Kevin R. Kasten, Amit D. Tevar, Rebecca Schuster, John Blanchard, Charles C. Caldwell, Michael J. Edwards, Alex B. Lentsch – 6 October 2010 – CXC chemokines mediate hepatic inflammation and injury following ischemia/reperfusion (I/R). More recently, signaling through CXC chemokine receptor‐2 (CXCR2) was shown to delay liver recovery and repair after I/R injury. The chemokine receptor CXCR1 shares ligands with CXCR2, yet nothing is known about its potential role in liver pathology.

Meeting vaccination quality measures for hepatitis A and B virus in patients with chronic hepatitis C infection

Jennifer R. Kramer, Christine Y. Hachem, Fasiha Kanwal, Minghua Mei, Hashem B. El‐Serag – 6 October 2010 – Coinfection with hepatitis A virus (HAV) or hepatitis B virus (HBV) in patients with chronic hepatitis C virus (HCV) is associated with increased morbidity and mortality. The Center for Medicare and Medicaid Services has identified HAV and HBV vaccination as a priority area for quality measurement in HCV. It is unclear to what extent patients with HCV meet these recommendations.

Apoptotic cells attenuate fulminant hepatitis by priming Kupffer cells to produce interleukin‐10 through membrane‐bound TGF‐β

Minggang Zhang, Sheng Xu, Yanmei Han, Xuetao Cao – 6 October 2010 – The liver, a unique tolerogenic organ, is regarded as the site to trap and destroy aging erythrocytes and activated T cells. However, to date, the mechanisms for why the liver is tolerogenic and whether liver Kupffer cells (KC) are critical phagocytes for apoptotic cells (AC) contributing to the liver immunosuppression remain unclear. Here we report that KC is the main phagocyte for AC in the liver.

Subscribe to