Christine M. Hunt – 6 October 2010

Tien‐Hau Lien, Mei‐Hwei Chang, Jia‐Feng Wu, Huey‐Ling Chen, Hung‐Chang Lee, An‐Chyi Chen, Mao‐Meng Tiao, Tzee‐Chung Wu, Yao‐Jong Yang, Chieh‐Chung Lin, Ming‐Wei Lai, Hong‐Yuan Hsu, Yen‐Hsuan Ni, the Taiwan Infant Stool Color Card Study Group – 6 October 2010 – In Taiwan, a screening system using an infant stool color card to promote the early diagnosis of biliary atresia (BA) was established in 2002. This study aimed to investigate the 5‐year outcome of BA before and after using the screening program. BA patients were divided into three cohorts according to their birth dates.

Weiqin Chen, Benny Chang, Lan Li, Lawrence Chan – 5 October 2010

Ricardo Moreno‐Otero, María Trapero‐Marugán, Luisa García‐Buey, Asunción García‐Sancchez – 1 October 2010

Jing Fu, Yao Chen, Jie Cao, Tao Luo, You‐Wen Qian, Wen Yang, Yi‐Bin Ren, Bo Su, Guang‐Wen Cao, Yuan Yang, Yi‐Qun Yan, Feng Shen, Meng‐Chao Wu, Gen‐Sheng Feng, Hong‐Yang Wang – 30 September 2010 – The overall survival of patients with hepatocellular carcinoma (HCC) remains poor, and the molecular mechanisms underlying HCC progression and aggressiveness are unclear. Here, we report that increased expression of p28GANK (Gankyrin, PSMD10, or p28) in human HCC predicts poor survival and disease recurrence after surgery.

Arthur W. Yan, Derrick E. Fouts, Johannes Brandl, Peter Stärkel, Manolito Torralba, Eckart Schott, Hide Tsukamoto, Karen E. Nelson, David A. Brenner, Bernd Schnabl – 30 September 2010 – The translocation of bacteria and bacterial products into the circulation contributes to alcoholic liver disease. Intestinal bacterial overgrowth is common in patients with alcoholic liver disease. The aims of our study were to investigate bacterial translocation, changes in the enteric microbiome, and its regulation by mucosal antimicrobial proteins in alcoholic liver disease.

Peter Jepsen, Peter Ott, Per Kragh Andersen, Henrik Toft Sørensen, Hendrik Vilstrup – 30 September 2010

Peter J. Lewindon, Ross W. Shepherd, Meagan J. Walsh, Ristan M. Greer, Richard Williamson, Tamara N. Pereira, Kieran Frawley, Scott C. Bell, Jeffery L. Smith, Grant A. Ramm – 30 September 2010 – Cystic fibrosis liver disease (CFLD), which results from progressive hepatobiliary fibrosis, is an important cause of morbidity and mortality, but it is difficult to identify before portal hypertension (PHT) ensues.

Krishna Banaudha, Michael Kaliszewski, Tamara Korolnek, Liliana Florea, Man Lung Yeung, Kuan‐Teh Jeang, Ajit Kumar – 30 September 2010 – MicroRNAs (miRNAs) are approximately 22‐nucleotide noncoding RNAs that constitute silencers of target gene expression. Aberrant expression of miRNA has been linked to a variety of cancers, including hepatocellular carcinoma (HCC). Hepatitis C virus (HCV) infection is considered a major cause of chronic liver disease and HCC, although the mechanism of virus infection–associated hepatocarcinogenesis remains unclear.

Stella M. Martínez, Gonzalo Crespo, Miquel Navasa, Xavier Forns – 30 September 2010 – Liver biopsy has long been an important tool for assessing the degree of liver fibrosis. Information on the presence and degree of liver fibrosis is useful before making therapeutic decisions or predicting disease outcomes. The need to stage liver fibrosis, however, should decrease as treatment options become more successful (as has occurred with viral hepatitis).