Retransplantation for donor‐derived neuroendocrine tumor

Rehana Begum, Denise Harnois, Raj Satyanarayana, Murli Krishna, Kevin C. Halling, George P. Kim, Justin H. Nguyen, Andrew P. Keaveny – 11 October 2010 – Although tumor transmission through liver transplantation (LT) is a rare occurrence, the consequences can be devastating, even when a very aggressive management approach is adopted. We report the case of a donor‐derived small cell neuroendocrine tumor (NET) in a patient who underwent LT for cholangiocarcinoma. Despite locoregional therapy, chemotherapy and ultimately retransplantation, the patient died from metastases.

Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease

James E. Nelson, Laura Wilson, Elizabeth M. Brunt, Matthew M. Yeh, David E. Kleiner, Aynur Unalp‐Arida, Kris V. Kowdley – 11 October 2010 – Previous studies examining the relationship between hepatic iron deposition and histological severity in nonalcoholic fatty liver disease (NAFLD) have been inconclusive. The goal of this study was to examine the relationship between hepatic iron deposition and liver histology in 849 patients enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network.

Effect of sorafenib on murine liver regeneration

Caroline Hora, Pamela Romanque, Jean‐François F. Dufour – 11 October 2010 – Hepatocellular carcinoma (HCC) is a common cause of cancer‐related death. Sorafenib prolongs survival of patients with advanced disease and is approved for the systemic treatment of unresectable HCC. It possesses antiangiogenic and antiproliferative properties by way of inhibition of the receptor tyrosine kinases vascular endothelial growth factor receptor 2 (VEGFR‐2) and platelet‐derived growth factor receptor‐beta 1/2 (PDGFR‐β) and the kinase RAF.

Apoptotic cells attenuate fulminant hepatitis by priming Kupffer cells to produce interleukin‐10 through membrane‐bound TGF‐β

Minggang Zhang, Sheng Xu, Yanmei Han, Xuetao Cao – 6 October 2010 – The liver, a unique tolerogenic organ, is regarded as the site to trap and destroy aging erythrocytes and activated T cells. However, to date, the mechanisms for why the liver is tolerogenic and whether liver Kupffer cells (KC) are critical phagocytes for apoptotic cells (AC) contributing to the liver immunosuppression remain unclear. Here we report that KC is the main phagocyte for AC in the liver.

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