Outcomes of orthotopic liver transplantation for hepatic sarcoidosis: An analysis of the United Network for organ sharing/organ Procurement and Transplantation Network data files for a comparative study with cholestatic liver diseases

Jason M. Vanatta, Kian A. Modanlou, Amanda G. Dean, Nosratollah Nezakatgoo, Luis Campos, Satheesh Nair, James D. Eason – 18 May 2011 – Hepatic sarcoidosis is a rare indication for liver transplantation. Using the United Network for Organ Sharing (UNOS)/Organ Procurement and Transplantation Network (OPTN) database, we evaluated patient and graft survival after orthotopic liver transplantation for sarcoidosis between October 1987 and December 2007.

Volumetry‐based selection of right posterior sector grafts for adult living donor liver transplantation

Bong‐Wan Kim, Weiguang Xu, Hee‐Jung Wang, Yong‐Keun Park, Kwangil Lee, Myung‐Wook Kim – 18 May 2011 – To determine the feasibility of volumetric criteria without anatomic exclusion for the selection of right posterior sector (RPS) grafts for adult‐to‐adult living donor liver transplantation (LDLT), we reviewed and compared our transplant data for RPS grafts and right lobe (RL) grafts.

Use of an upper midline incision for living donor partial hepatectomy: A series of 143 consecutive cases

Kwang‐Woong Lee, Seong Hoon Kim, Sung‐Sik Han, Young‐Kyu Kim, Seong Yeon Cho, Tae You, Sang‐Jae Park – 16 May 2011 – Over a period of 2 years, we used an upper midline incision (UMI) without laparoscopic assistance in 143 consecutive living donor partial hepatectomy (LDPH) procedures, regardless of the graft type or the donor age, sex, body mass index, or body shape. Here we report surgical recommendations based on our experience with the use of UMIs in this context.

Dendritic cell depletion exacerbates acetaminophen hepatotoxicity

Michael K. Connolly, Diego Ayo, Ashim Malhotra, Michael Hackman, Andrea S. Bedrosian, Junaid Ibrahim, Napoleon E. Cieza‐Rubio, Andrew H. Nguyen, Justin R. Henning, Monica Dorvil‐Castro, H. Leon Pachter, George Miller – 13 May 2011 – Acetaminophen (APAP) overdose is one of the most frequent causes of acute liver failure in the United States and is primarily mediated by toxic metabolites that accumulate in the liver upon depletion of glutathione stores.

Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4‐bis [2‐(3,5‐dichloropyridyloxy)] benzene is suppressed in hepatocyte‐targeted glypican 3 transgenic mice

Chih‐Wen Lin, Wendy M. Mars, Shirish Paranjpe, Shashikiran Donthamsetty, Vishakha S. Bhave, Liang‐I Kang, Anne Orr, William C. Bowen, Aaron W. Bell, George K. Michalopoulos – 13 May 2011 – Glypican 3 (GPC3) is a family of glycosylphosphatidylinositol‐anchored, cell‐surface heparan sulfate proteoglycans. Loss‐of‐function mutations of GPC3 cause Simpson‐Golabi‐Behmel syndrome characterized by overgrowth of multiple organs, including liver.

Effect of vitamin K2 on the recurrence of hepatocellular carcinoma

Haruhiko Yoshida, Yasushi Shiratori, Masatoshi Kudo, Shuichiro Shiina, Toshihiko Mizuta, Masamichi Kojiro, Kyosuke Yamamoto, Yukihiro Koike, Kenichi Saito, Nozomu Koyanagi, Takao Kawabe, Seiji Kawazoe, Haruhiko Kobashi, Hiroshi Kasugai, Yukio Osaki, Yasuyuki Araki, Namiki Izumi, Hiroko Oka, Kunihiko Tsuji, Joji Toyota, Toshihito Seki, Toshiya Osawa, Naohiko Masaki, Masao Ichinose, Masataka Seike, Akihisa Ishikawa, Yoshiyuki Ueno, Kazumi Tagawa, Ryoko Kuromatsu, Shotaro Sakisaka, Hiroshi Ikeda, Hidekatsu Kuroda, Hiroyuki Kokuryu, Tatsuya Yamashita, Isao Sakaida, Tetsuo Katamoto, Kentaro Kiku

Genomewide microRNA down‐regulation as a negative feedback mechanism in the early phases of liver regeneration

Jingmin Shu, Betsy T. Kren, Zhilian Xia, Phillip Y.‐P. Wong, Lihua Li, Eric A. Hanse, Michael X. Min, Bingshan Li, Jeffrey H. Albrecht, Yan Zeng, Subbaya Subramanian, Clifford J. Steer – 13 May 2011 – The liver is one of the few organs that have the capacity to regenerate in response to injury. We carried out genomewide microRNA (miRNA) microarray studies during liver regeneration in rats after 70% partial hepatectomy (PH) at early and mid time points to more thoroughly understand their role. At 3, 12, and 18 hours post‐PH ∼40% of the miRNAs tested were up‐regulated.

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