Apoptotic cells attenuate fulminant hepatitis by priming Kupffer cells to produce interleukin‐10 through membrane‐bound TGF‐β

Minggang Zhang, Sheng Xu, Yanmei Han, Xuetao Cao – 6 October 2010 – The liver, a unique tolerogenic organ, is regarded as the site to trap and destroy aging erythrocytes and activated T cells. However, to date, the mechanisms for why the liver is tolerogenic and whether liver Kupffer cells (KC) are critical phagocytes for apoptotic cells (AC) contributing to the liver immunosuppression remain unclear. Here we report that KC is the main phagocyte for AC in the liver.

Meeting vaccination quality measures for hepatitis A and B virus in patients with chronic hepatitis C infection

Jennifer R. Kramer, Christine Y. Hachem, Fasiha Kanwal, Minghua Mei, Hashem B. El‐Serag – 6 October 2010 – Coinfection with hepatitis A virus (HAV) or hepatitis B virus (HBV) in patients with chronic hepatitis C virus (HCV) is associated with increased morbidity and mortality. The Center for Medicare and Medicaid Services has identified HAV and HBV vaccination as a priority area for quality measurement in HCV. It is unclear to what extent patients with HCV meet these recommendations.

CXC chemokine receptor‐1 is expressed by hepatocytes and regulates liver recovery after hepatic ischemia/reperfusion injury

Callisia Clarke, Satoshi Kuboki, Nozomu Sakai, Kevin R. Kasten, Amit D. Tevar, Rebecca Schuster, John Blanchard, Charles C. Caldwell, Michael J. Edwards, Alex B. Lentsch – 6 October 2010 – CXC chemokines mediate hepatic inflammation and injury following ischemia/reperfusion (I/R). More recently, signaling through CXC chemokine receptor‐2 (CXCR2) was shown to delay liver recovery and repair after I/R injury. The chemokine receptor CXCR1 shares ligands with CXCR2, yet nothing is known about its potential role in liver pathology.

Effects of the infant stool color card screening program on 5‐year outcome of biliary atresia in taiwan

Tien‐Hau Lien, Mei‐Hwei Chang, Jia‐Feng Wu, Huey‐Ling Chen, Hung‐Chang Lee, An‐Chyi Chen, Mao‐Meng Tiao, Tzee‐Chung Wu, Yao‐Jong Yang, Chieh‐Chung Lin, Ming‐Wei Lai, Hong‐Yuan Hsu, Yen‐Hsuan Ni, the Taiwan Infant Stool Color Card Study Group – 6 October 2010 – In Taiwan, a screening system using an infant stool color card to promote the early diagnosis of biliary atresia (BA) was established in 2002. This study aimed to investigate the 5‐year outcome of BA before and after using the screening program. BA patients were divided into three cohorts according to their birth dates.

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