Hypomagnesemia and the risk of new‐onset diabetes after liver transplantation

Steven Van Laecke, Federico Desideri, Anja Geerts, Hans Van Vlierberghe, Frederik Berrevoet, Xavier Rogiers, Roberto Troisi, Bernard de Hemptinne, Raymond Vanholder, Isabelle Colle – 28 October 2010 – New‐onset diabetes after transplantation (NODAT) is a frequent complication after liver transplantation and has a negative impact on both patient and graft survival.

Moderate ascites identifies patients with low model for end‐stage liver disease scores awaiting liver transplantation who have a high mortality risk

Ma Somsouk, Rachel Kornfield, Eric Vittinghoff, John M. Inadomi, Scott W. Biggins – 28 October 2010 – Donor livers are offered to patients with the highest risk of death. How ascites could inform risk models to reduce liver transplant wait‐list mortality is unclear. All adult candidates for primary liver transplantation for cirrhosis without exception points who were registered with the Organ Procurement and Transplantation Network from 2005 to 2007 composed our study cohort.

Inhibition of inducible nitric oxide synthase prevents graft injury after transplantation of livers from rats after cardiac death

Yanjun Shi, Hasibur Rehman, Gary L. Wright, Zhi Zhong – 28 October 2010 – This study investigated the roles of inducible nitric oxide synthase (iNOS) in the failure of rat liver grafts from cardiac death donors (GCDD). Livers were explanted after 30‐minute aorta clamping and implanted after 4‐hour storage in University of Wisconsin solution. The iNOS expression increased slightly in grafts from non–cardiac death donors (GNCDD) but markedly in GCDD.

Differences in portal hemodynamics between whole liver transplantation and living donor liver transplantation

Shui‐Ming Jiang, Qi‐Shun Zhang, Guang‐Wen Zhou, Shi‐Feng Huang, Hai‐Ming Lu, Cheng‐Hong Peng – 28 October 2010 – The aim of this study was to investigate the differences in portal hemodynamics between whole liver transplantation and living donor liver transplantation (LDLT). Twenty patients who underwent LDLT (the L group) and 42 patients who underwent whole liver transplantation (the W group) were enrolled, and colored Doppler ultrasonography was performed preoperatively and on postoperative days (PODs) 1, 3, 5, 7, 30, and 90.

Differential effects of plasma and red blood cell transfusions on acute lung injury and infection risk following liver transplantation

Alexander B. Benson, James R. Burton, Gregory L. Austin, Scott W. Biggins, Michael A. Zimmerman, Igal Kam, Susan Mandell, Christopher C. Silliman, Hugo Rosen, Marc Moss – 27 October 2010 – Patients with chronic liver disease have an increased risk of developing transfusion‐related acute lung injury (TRALI) from plasma‐containing blood products. Similarly, red blood cell transfusions have been associated with postoperative and nosocomial infections in surgical and critical care populations.

Native macrophages genetically modified to express heme oxygenase 1 protect rat liver transplants from ischemia/reperfusion injury

Xiu‐Da Shen, Bibo Ke, Yoichiro Uchida, Haofeng Ji, Feng Gao, Yuan Zhai, Ronald W. Busuttil, Jerzy W. Kupiec‐Weglinski – 27 October 2010 – We investigated whether native macrophages overexpressing heme oxygenase 1 (HO‐1) could protect rat orthotopic liver transplant (OLT) against cold ischemia/reperfusion injury (IRI). Livers from Sprague‐Dawley rats were stored at 4°C in University of Wisconsin solution for 24 hours, and then they were transplanted into syngeneic recipients.

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