Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice

Kristina M. Mueller, Jan‐Wilhelm Kornfeld, Katrin Friedbichler, Leander Blaas, Gerda Egger, Harald Esterbauer, Peter Hasselblatt, Michaela Schlederer, Susanne Haindl, Kay‐Uwe Wagner, David Engblom, Guenter Haemmerle, Dagmar Kratky, Veronika Sexl, Lukas Kenner, Andrey V. Kozlov, Luigi Terracciano, Rudolf Zechner, Guenther Schuetz, Emilio Casanova, J. Andrew Pospisilik, Markus H.

The assessment of serum hepatitis C virus RNA 12 weeks after the end of treatment using TaqMan polymerase chain reaction is less relevant than after 24 weeks for predicting sustained virological response

SWItch/sucrose nonfermentable (SWI/SNF) complex subunit BAF60a integrates hepatic circadian clock and energy metabolism

Weiwei Tao, Siyu Chen, Guangsen Shi, Jinhu Guo, Ying Xu, Chang Liu – 2 July 2011 – Many aspects of energy metabolism, including glucose and lipid homeostasis and mitochondrial oxidative metabolism, are under precise control by the mammalian circadian clock. However, the molecular mechanism for coordinate integration of the circadian clock and various metabolic pathways is poorly understood. Here we show that BAF60a, a chromatin‐remodeling complex subunit, is rhythmically expressed in the liver of mice.

Inflammatory response to liver fluke Opisthorchis viverrini in mice depends on host master coregulator MTA1, a marker for parasite‐induced cholangiocarcinoma in humans

Sujit S. Nair, Anitha Bommana, Suresh B. Pakala, Kazufumi Ohshiro, Amanda J. Lyon, Sutas Suttiprapa, Maria V. Periago, Thewarach Laha, Peter J. Hotez, Jeffrey M. Bethony, Banchob Sripa, Paul J.

Fighting against viral hepatitis: Lessons from Taiwan

Ding‐Shinn Chen – 30 June 2011 – Viral hepatitis and its sequelae are important health problems worldwide, including Taiwan. For the last 40 years, Taiwan's scientists and health care providers have worked hard to control these sequelae, and the results have been excellent. The author, Ding‐Shinn Chen, had a key role in planning and establishing the control program in Taiwan, and participated in the endeavors from the very beginning.

Cross‐presentation of antigen by diverse subsets of murine liver cells

Mohammad R. Ebrahimkhani, Isaac Mohar, Ian N. Crispe – 30 June 2011 – Antigen cross‐presentation is a principal function of specialized antigen‐presenting cells of bone marrow origin such as dendritic cells. Although these cells are sometimes known as “professional” antigen‐presenting cells, nonbone marrow‐derived cells may also act as antigen‐presenting cells.

Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll‐like receptor 9 in mice

Hai Huang, John Evankovich, Wei Yan, Gary Nace, Lemeng Zhang, Mark Ross, Xinghua Liao, Timothy Billiar, Jun Xu, Charles T. Esmon, Allan Tsung – 30 June 2011 – Sterile inflammatory insults are known to activate innate immunity and propagate organ damage through the recognition of extracellular damage‐associated molecular pattern (DAMP) molecules. Although DAMPs such as endogenous DNA and nuclear high‐mobility group box 1 have been shown to be critical in sterile inflammation, the role of nuclear histone proteins has not yet been investigated.

Novel poly (ADP‐ribose) polymerase 1 binding motif in hepatitis B virus core promoter impairs DNA damage repair

Hui‐Ling Ko, Ee‐Chee Ren – 30 June 2011 – It is well‐established that hepatitis B virus (HBV) infection is associated with the development of hepatocellular carcinoma (HCC), but patients with high viral DNA load have significantly higher risk. As host factors are required for efficient viral replication and may, therefore, contribute to high viral DNA load, we screened for host factors that can transcriptionally activate the HBV core promoter (HBVCP).

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