HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity

Mitchell R. McGill, Hui‐Min Yan, Anup Ramachandran, Gordon J. Murray, Douglas E. Rollins, Hartmut Jaeschke – 17 December 2010 – Acetaminophen (APAP) overdose is the leading cause of acute liver failure in Western countries. In the last four decades much progress has been made in our understanding of APAP‐induced liver injury through rodent studies. However, some differences exist in the time course of injury between rodents and humans. To study the mechanism of APAP hepatotoxicity in humans, a human‐relevant in vitro system is needed.

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

Jörg Schrader, Timothy T. Gordon‐Walker, Rebecca L. Aucott, Mariëlle van Deemter, Alexander Quaas, Shaun Walsh, Daniel Benten, Stuart J. Forbes, Rebecca G. Wells, John P. Iredale – 14 December 2010 – There is increasing evidence that the physical environment is a critical mediator of tumor behavior. Hepatocellular carcinoma (HCC) develops within an altered biomechanical environment, and increasing matrix stiffness is a strong predictor of HCC development.

Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: mechanisms and effects on liver regeneration

Mariëlle Verweij, Tessa M. van Ginhoven, James R. Mitchell, Wim Sluiter, Sandra van den Engel, Henk P. Roest, Elham Torabi, Jan N. M. IJzermans, Jan H. J. Hoeijmakers, Ron W. F. de Bruin – 14 December 2010 – We show that brief periods of fasting induce functional changes similar to those induced by long‐term dietary restriction in mice, and these changes include protection from ischemia/reperfusion (I/R) injury. In this study, we investigated the mechanisms of protection induced by fasting, and we determined the effect on liver regeneration after partial hepatectomy.

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