No resistance to tenofovir disoproxil fumarate detected after up to 144 weeks of therapy in patients monoinfected with chronic hepatitis B virus

Andrea Snow‐Lampart, Brandi Chappell, Maria Curtis, Yuao Zhu, Florence Myrick, James Schawalder, Kathryn Kitrinos, Evguenia S. Svarovskaia, Michael D. Miller, Jeff Sorbel, Jenny Heathcote, Patrick Marcellin, Katyna Borroto‐Esoda – 18 November 2010 – Tenofovir disoproxil fumarate (TDF) is a nucleotide analogue with potent activity against human immunodeficiency virus type 1 and hepatitis B virus (HBV). To date, no reports of HBV clinical resistance to TDF have been confirmed.

Autoimmune acute liver failure: Proposed clinical and histological criteria

R. Todd Stravitz, Jay H. Lefkowitch, Robert J. Fontana, M. Eric Gershwin, Patrick S. C. Leung, Richard K. Sterling, Michael P. Manns, Gary L. Norman, William M. Lee, and the Acute Liver Failure Study Group – 18 November 2010 – Identifying autoimmune hepatitis as the etiology of acute liver failure (ALF) is potentially important, because administering corticosteroids might avoid the need for liver transplantation. However, clinical and histological criteria of autoimmune ALF (AI‐ALF) have not been defined.

Endocannabinoids in liver disease

Joseph Tam, Jie Liu, Bani Mukhopadhyay, Resat Cinar, Grzegorz Godlewski, George Kunos – 18 November 2010 – Endocannabinoids are lipid mediators of the same cannabinoid (CB) receptors that mediate the effects of marijuana. The endocannabinoid system (ECS) consists of CB receptors, endocannabinoids, and the enzymes involved in their biosynthesis and degradation, and it is present in both brain and peripheral tissues, including the liver. The hepatic ECS is activated in various liver diseases and contributes to the underlying pathologies.

Endoplasmic reticulum stress is a mediator of posttransplant injury in severely steatotic liver allografts

Christopher D. Anderson, Gundumi Upadhya, Kendra D. Conzen, Jianlou Jia, Elizabeth M. Brunt, Venkataswarup Tiriveedhi, Yan Xie, Sabarinathan Ramachandran, Thalachallour Mohanakumar, Nicholas O. Davidson, William C. Chapman – 16 November 2010 – Hepatic steatosis continues to present a major challenge in liver transplantation. These organs have been shown to have increased susceptibility to cold ischemia/reperfusion (CIR) injury in comparison with otherwise comparable lean livers; the mechanisms governing this increased susceptibility to CIR injury are not fully understood.

Epidural analgesia provides better pain management after live liver donation: A retrospective study

Hance Clarke, Tony Chandy, Coimbatore Srinivas, Salima Ladak, Nobuhiko Okubo, Nicholas Mitsakakis, Susan Holtzman, David Grant, Stuart A. McCluskey, Joel Katz – 16 November 2010 – Despite the increase in surgical volumes of live liver donation, there has been very little documentation of the postoperative pain experience.

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