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Constitutive release of powerful antioxidant‐scavenging activity by hepatic stellate cells: Protection of hepatocytes from ischemia/reperfusion injury

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Noor Mohamed Jameel, Chinnasamy Thirunavukkarasu, Noriko Murase, Michael Cascio, John Prelich, Shuting Yang, Stephen A. K Harvey, Chandrashekhar R Gandhi – 29 November 2010 – Within the liver, reactive oxygen species produced by infiltrating blood cells and Kupffer cells (resident macrophages) can injure hepatocytes. We hypothesized that hepatocyte survival is influenced by the relatively small juxtaposed population of hepatic stellate cells (HSCs).

Percutaneously placed covered retrievable stents for the treatment of biliary anastomotic strictures following living donor liver transplantation

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Jinoo Kim, Gi‐Young Ko, Kyu‐Bo Sung, Dong Il Gwon, Sung‐Gyu Lee, Kwang‐Mi Kim, Kyung‐Ah Kim, Hyun‐Ki Yoon – 29 November 2010 – This study evaluated the feasibility and efficacy of covered retrievable stent placement compared with drainage catheter placement for treating biliary anastomotic strictures following living donor liver transplantation (LDLT).

Addendum

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29 November 2010

Feasibility of using a liver infected with Clonorchis sinensis for liver transplantation: Fourteen cases

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Zhi‐Jun Zhu, Zhong‐Yang Shen, Wei Gao, Hong Zheng, Yong‐Lin Deng, Cheng Pan, Li‐Ying Sun, Zhi‐Gui Zeng, Ji‐San Sun – 29 November 2010 – Use of livers infected with Clonorchis sinensis as donor organs for transplantation is controversial because of the potential associated risks. The low availability of donor livers at Tianjin First Center Hospital since 2003 prompted us to undertake cadaveric liver transplantation in 14 patients using donor livers infected with C. sinensis.

Pathogen DNA also contributes to interferon regulatory factor 3 activation in hepatic cells: Implications for alcoholic liver diseases

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Yue Wang, Yingjun Guo, Fang Wang, Shuhan Sun – 24 November 2010

Modeling hepatitis B virus X–induced hepatocellular carcinoma in mice with the sleeping beauty transposon system

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Vincent W. Keng, Barbara R. Tschida, Jason B. Bell, David A. Largaespada – 24 November 2010 – The mechanisms associated with hepatitis B virus (HBV)–induced hepatocellular carcinoma (HCC) remain elusive, and there are currently no well‐established animal models for studying this disease. Using the Sleeping Beauty transposon as a delivery system, we introduced an oncogenic component of HBV, the hepatitis B virus X (HBx) gene, into the livers of fumarylacetoacetate hydrolase (Fah) mutant mice via hydrodynamic tail vein injections.