Tomasz Kozlowski, Tara Rubinas, Volker Nickeleit, John Woosley, John Schmitz, Dana Collins, Paul Hayashi, Anthony Passannante, Kenneth Andreoni – 3 December 2010 – The importance of antibody‐mediated rejection (AMR) in ABO‐compatible liver transplantation is controversial. Here we report a prospective series of liver recipients with a preoperative positive crossmatch. To establish the diagnosis of AMR in liver recipients, the criteria described for kidney allografts were adopted.

Philipp Dutkowski, Christian E. Oberkofler, Markus Béchir, Beat Müllhaupt, Andreas Geier, Dimitri A. Raptis, Pierre‐Alain Clavien – 3 December 2010 – We analyzed the first 100 patients who underwent liver transplantation by Model for End‐Stage Liver Disease (MELD) allocation, and compared the outcome of patients on the waiting list and after orthotopic liver transplantation with the last 100 patients who underwent transplantation prior to the introduction of the MELD system in July 2007.

Emmanuel Boleslawski, Samia Ben Othman, Lynda Aoudjehane, Sandrine Chouzenoux, Olivier Scatton, Olivier Soubrane, Yvon Calmus, Nadira Delhem, Filomena Conti – 3 December 2010 – At present, no method is available for accurately monitoring the degree of immunosuppression induced by antirejection therapies. The aim of this study was to determine whether CD28 and CD38 expression by peripheral blood mononuclear cells could be useful in predicting the development of de novo malignancies after liver transplantation.

Dmitri Bezinover, Zakiyah Kadry, Paul McCullough, Patrick M. McQuillan, Todahiro Uemura, Kelli Welker, Andrea M. Mastro, Piotr K. Janicki – 3 December 2010 – The objectives of this prospective, observational study were (1) to determine whether a transplanted liver graft releases proinflammatory cytokines into the systemic circulation upon reperfusion and (2) to determine whether they contribute to any subsequent hemodynamic instability observed after graft reperfusion (if this release occurs).

Ana Moreno, Jesús Fortún, Javier Graus, Miguel A. Rodriguez‐Gandía, Carmen Quereda, María J. Pérez‐Elías, Javier Nuño, Philip Wikman, Santiago Moreno, Rafael Bárcena – 3 December 2010 – Statins are relatively safe first‐line agents to use in the setting of dyslipidemia associated with immunosuppressive therapy in subjects undergoing liver transplantation, and also in HIV‐infected patients with dyslipidemia due to antiretroviral drugs, especially ritonavir‐boosted protease inhibitors.

Shari S. Rogal, Douglas Landsittel, Owen Surman, Raymond T. Chung, Anna Rutherford – 3 December 2010 – Depression is a common problem among patients awaiting organ transplantation, but little is known about the impact of depression and its treatment on the outcomes of liver transplantation. In this retrospective cohort analysis, we studied all patients over 18 years of age who underwent liver transplantation during a 5‐year period (2004‐2008) at a single center. Among 179 recipients, 65 patients had depression, as defined by a health care provider assessment, before transplantation.

Paolo R. Salvalaggio, Nino Dzebisashvili, Kara E. MacLeod, Krista L. Lentine, Adrian Gheorghian, Mark A. Schnitzler, Samuel Hohmann, Dorry L. Segev, Sommer E. Gentry, David A. Axelrod – 3 December 2010 – Accurate assessment of the impact of donor quality on liver transplant (LT) costs has been limited by the lack of a large, multicenter study of detailed clinical and economic data.

Shin Hwang, Chul‐Soo Ahn, Gi‐Won Song, Ki‐Hun Kim, Deok‐Bog Moon, Heung‐Bum Oh, Young‐Suk Lim, Han Chu Lee, Tae‐Yong Ha, Dong‐Hwan Jung, Young‐Hwa Chung, Sung‐Gyu Lee – 3 December 2010 – A considerable proportion of liver transplantation recipients who receive hepatitis B immunoglobulin (HBIG) monotherapy for hepatitis B virus (HBV) prophylaxis develop resistance to HBIG. We retrospectively assessed the efficacy of HBV prophylaxis in 1524 patients who received primary high‐dose HBIG monotherapy (n = 1463) or with a preemptive antiviral add‐on as secondary combination therapy (n = 61).

Daniela E. Oprea‐Lager, Bastiaan J. Sorgdrager, J. Wouter Jukema, Roderick W. C. Scherptong, Jan Ringers, Minneke J. Coenraad, Bart van Hoek, Marcel P. M. Stokkel – 3 December 2010 – A cardiac evaluation before orthotopic liver transplantation (OLT) is imperative. Previous investigations have demonstrated that mild to moderate reversible perfusion defects on myocardial perfusion scintigraphy (MPS) in general are associated with a low risk for perioperative cardiac events.

Noor Mohamed Jameel, Chinnasamy Thirunavukkarasu, Noriko Murase, Michael Cascio, John Prelich, Shuting Yang, Stephen A. K Harvey, Chandrashekhar R Gandhi – 29 November 2010 – Within the liver, reactive oxygen species produced by infiltrating blood cells and Kupffer cells (resident macrophages) can injure hepatocytes. We hypothesized that hepatocyte survival is influenced by the relatively small juxtaposed population of hepatic stellate cells (HSCs).