Pedro M. Baptista, Mohummad M. Siddiqui, Genevieve Lozier, Sergio R. Rodriguez, Anthony Atala, Shay Soker – 12 November 2010 – A major roadblock to successful organ bioengineering is the need for a functional vascular network within the engineered tissue. Here, we describe the fabrication of three‐dimensional, naturally derived scaffolds with an intact vascular tree. Livers from different species were perfused with detergent to selectively remove the cellular components of the tissue while preserving the extracellular matrix components and the intact vascular network.

B. Nelson Chau, David A. Brenner – 12 November 2010

Jennifer M. Loftis, Benjamin J. Morasco, Peter Hauser – 4 November 2010

Aleksander Krag, Søren Møller, Flemming Bendtsen – 4 November 2010

Niraj Khandelwal, Laura P. James, Corron Sanders, Anne M. Larson, William M. Lee, and the Acute Liver Failure Study Group – 4 November 2010 – Despite extensive investigations, the cause of liver injury in 14% of patients with acute liver failure remains unknown (indeterminate). In a pilot study using a novel assay, highly specific acetaminophen‐cysteine adducts were detected in 7 of 36 indeterminate patients (19%).

Chung‐Feng Huang, Chia‐Yen Dai, Jee‐Fu Huang, Wan‐Long Chuang, Ming‐Lung Yu – 4 November 2010

Min Guan, Linbing Qu, Wenjuan Tan, Ling Chen, Chi‐Wai Wong – 4 November 2010 – Hepatocyte nuclear factor‐4 alpha (HNF‐4α) is an important transcription factor governing the expression of genes involved in multiple metabolic pathways. Secreted phospholipase A2 GXIIB (PLA2GXIIB) is an atypical member of a class of secreted phospholipases A2. We establish in this study that PLA2GXIIB is an HNF‐4α target gene. We demonstrate that HNF‐4α binds to a response element on the PLA2GXIIB promoter. Moreover, HNF‐4α agonists induce PLA2GXIIB expression in human hepatocarcinoma cells.

Wan‐Hsin Wen, Huey‐Ling Chen, Yen‐Hsuan Ni, Hong‐Yuan Hsu, Jia‐Horng Kao, Fu‐Chang Hu, Mei‐Hwei Chang – 4 November 2010 – Genotypes B and C are the major hepatitis B virus (HBV) genotypes in Taiwan, and genotype C is associated with more severe liver disease than genotype B. Whether the implementation of the hepatitis B immunization program has affected the secular trend of the HBV genotype distribution remains unknown.

Eric Vibert, Jean‐Charles Duclos‐Vallée, Maria‐Rosa Ghigna, Emir Hoti, Chady Salloum, Catherine Guettier, Denis Castaing, Didier Samuel, René Adam – 4 November 2010 – Liver transplantation (LT) has become an accepted therapy for end‐stage liver disease in human immunodeficiency virus–positive (HIV+) patients, but the specific results of LT for hepatocellular carcinoma (HCC) are unknown. Between 2003 and 2008, 21 HIV+ patients and 65 HIV− patients with HCC were listed for LT at a single institution. Patient characteristics and pathological features were analyzed.

Marco Antonio Montes‐Cano, José Raúl García‐Lozano, Cristina Abad‐Molina, Fuensanta Torrecillas, Almudena Torres, Luis Felipe Lopez‐Cortes, Antonio Núñez‐Roldán, María Francisca González‐Escribano – 4 November 2010