What goes up must come down: The emerging role of microRNA in fibrosis
B. Nelson Chau, David A. Brenner – 12 November 2010
Depression and antiviral response to interferon‐based therapy for hepatitis C virus infection
Jennifer M. Loftis, Benjamin J. Morasco, Peter Hauser – 4 November 2010
Hyponatremia in patients treated with terlipressin: Mechanisms and implications for clinical practice
Aleksander Krag, Søren Møller, Flemming Bendtsen – 4 November 2010
Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure
Niraj Khandelwal, Laura P. James, Corron Sanders, Anne M. Larson, William M. Lee, and the Acute Liver Failure Study Group – 4 November 2010 – Despite extensive investigations, the cause of liver injury in 14% of patients with acute liver failure remains unknown (indeterminate). In a pilot study using a novel assay, highly specific acetaminophen‐cysteine adducts were detected in 7 of 36 indeterminate patients (19%).
Linkage of the hepatitis C virus genotype and interleukin‐28B genetic polymorphisms in Asian patients
Chung‐Feng Huang, Chia‐Yen Dai, Jee‐Fu Huang, Wan‐Long Chuang, Ming‐Lung Yu – 4 November 2010
Hepatocyte nuclear factor‐4 alpha regulates liver triglyceride metabolism in part through secreted phospholipase A2 GXIIB
Min Guan, Linbing Qu, Wenjuan Tan, Ling Chen, Chi‐Wai Wong – 4 November 2010 – Hepatocyte nuclear factor‐4 alpha (HNF‐4α) is an important transcription factor governing the expression of genes involved in multiple metabolic pathways. Secreted phospholipase A2 GXIIB (PLA2GXIIB) is an atypical member of a class of secreted phospholipases A2. We establish in this study that PLA2GXIIB is an HNF‐4α target gene. We demonstrate that HNF‐4α binds to a response element on the PLA2GXIIB promoter. Moreover, HNF‐4α agonists induce PLA2GXIIB expression in human hepatocarcinoma cells.
Secular trend of the viral genotype distribution in children with chronic hepatitis B virus infection after universal infant immunization
Wan‐Hsin Wen, Huey‐Ling Chen, Yen‐Hsuan Ni, Hong‐Yuan Hsu, Jia‐Horng Kao, Fu‐Chang Hu, Mei‐Hwei Chang – 4 November 2010 – Genotypes B and C are the major hepatitis B virus (HBV) genotypes in Taiwan, and genotype C is associated with more severe liver disease than genotype B. Whether the implementation of the hepatitis B immunization program has affected the secular trend of the HBV genotype distribution remains unknown.
Liver transplantation for hepatocellular carcinoma: The impact of human immunodeficiency virus infection
Eric Vibert, Jean‐Charles Duclos‐Vallée, Maria‐Rosa Ghigna, Emir Hoti, Chady Salloum, Catherine Guettier, Denis Castaing, Didier Samuel, René Adam – 4 November 2010 – Liver transplantation (LT) has become an accepted therapy for end‐stage liver disease in human immunodeficiency virus–positive (HIV+) patients, but the specific results of LT for hepatocellular carcinoma (HCC) are unknown. Between 2003 and 2008, 21 HIV+ patients and 65 HIV− patients with HCC were listed for LT at a single institution. Patient characteristics and pathological features were analyzed.
Reply:
Marco Antonio Montes‐Cano, José Raúl García‐Lozano, Cristina Abad‐Molina, Fuensanta Torrecillas, Almudena Torres, Luis Felipe Lopez‐Cortes, Antonio Núñez‐Roldán, María Francisca González‐Escribano – 4 November 2010
Visceral adiposity index is associated with histological findings and high viral load in patients with chronic hepatitis C due to genotype 1
Salvatore Petta, Marco Amato, Daniela Cabibi, Calogero Cammà, Vito Di Marco, Carla Giordano, Aldo Galluzzo, Antonio Craxì – 29 October 2010 – Metabolic factors have been associated with liver damage in patients with genotype 1 chronic hepatitis C (G1 CHC). We tested visceral adiposity index (VAI), a new marker of adipose dysfunction in G1 CHC, patients to assess its association with host and viral factors and its link to both histological findings and sustained virological response (SVR).