Native macrophages genetically modified to express heme oxygenase 1 protect rat liver transplants from ischemia/reperfusion injury

Xiu‐Da Shen, Bibo Ke, Yoichiro Uchida, Haofeng Ji, Feng Gao, Yuan Zhai, Ronald W. Busuttil, Jerzy W. Kupiec‐Weglinski – 27 October 2010 – We investigated whether native macrophages overexpressing heme oxygenase 1 (HO‐1) could protect rat orthotopic liver transplant (OLT) against cold ischemia/reperfusion injury (IRI). Livers from Sprague‐Dawley rats were stored at 4°C in University of Wisconsin solution for 24 hours, and then they were transplanted into syngeneic recipients.

Differential effects of plasma and red blood cell transfusions on acute lung injury and infection risk following liver transplantation

Alexander B. Benson, James R. Burton, Gregory L. Austin, Scott W. Biggins, Michael A. Zimmerman, Igal Kam, Susan Mandell, Christopher C. Silliman, Hugo Rosen, Marc Moss – 27 October 2010 – Patients with chronic liver disease have an increased risk of developing transfusion‐related acute lung injury (TRALI) from plasma‐containing blood products. Similarly, red blood cell transfusions have been associated with postoperative and nosocomial infections in surgical and critical care populations.

Quantitation of pretreatment serum interferon‐γ–inducible protein‐10 improves the predictive value of an IL28B gene polymorphism for hepatitis C treatment response

Jama M. Darling, Jeroen Aerssens, Gregory Fanning, John G. McHutchison, David B. Goldstein, Alexander J. Thompson, Kevin V. Shianna, Nezam H. Afdhal, Michael L. Hudson, Charles D. Howell, Willem Talloen, Jacques Bollekens, Mieke De Wit, Annick Scholliers, Michael W. Fried – 26 October 2010 – Polymorphisms of the IL28B gene are highly associated with sustained virological response (SVR) in patients with chronic hepatitis C treated with peginterferon and ribavirin. Quantitation of interferon‐γ–inducible protein‐10 (IP‐10) may also differentiate antiviral response.

Interferon induced protein 10 remains a useful biomarker of treatment failure in patients stratified for the interleukin‐28B rs12979860 Haplotype

Matthew L. Albert, Armanda Casrouge, Stéphane Chevaliez, Christophe Hézode, Isabelle Rosa, Philippe Renard, Vincent Mallet, Arnaud Fontanet, Jean‐Michel Pawlotsky, Stanislas Pol – 26 October 2010

Hepatitis C pharmacogenetics: State of the art in 2010

Nezam H. Afdhal, John G. McHutchison, Stefan Zeuzem, Alessandra Mangia, Jean‐Michel Pawlotsky, Jeffrey S. Murray, Kevin V. Shianna, Yasuhito Tanaka, David L. Thomas, David R. Booth, David B. Goldstein, for the Pharmacogenetics and Hepatitis C Meeting Participants – 26 October 2010 – In 2009, a correlated set of polymorphisms in the region of the interleukin‐28B (IL28B) gene were associated with clearance of genotype 1 hepatitis C virus (HCV) in patients treated with pegylated interferon‐alfa and ribavirin.

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