Lucia Pacifico, Caterina Anania, Francesco Martino, Vito Cantisani, Roberto Pascone, Andrea Marcantonio, Claudio Chiesa – 29 October 2010 – Nonalcoholic fatty liver disease (NAFLD) has been consistently found to be associated with features of the metabolic syndrome (MS), a condition carrying a high risk of cardiovascular events. The present study aimed to determine whether, in children and adolescents, NAFLD is atherogenic beyond its association with MS and its components.

Jin‐Ping Lai, Abdul M. Oseini, Catherine D. Moser, Chunrong Yu, Sherine F. Elsawa, Chunling Hu, Ikuo Nakamura, Tao Han, Ileana Aderca, Hajime Isomoto, Megan M. Garrity‐Park, Abdirashid M. Shire, Jia Li, Schuyler O. Sanderson, Alex A. Adjei, Martin E. Fernandez‐Zapico, Lewis R. Roberts – 29 October 2010 – Heparan sulfate proteoglycans (HSPGs) act as coreceptors or storage sites for growth factors and cytokines such as fibroblast growth factor and Wnts. Glypican 3 (GPC3) is the most highly expressed HSPG in hepatocellular carcinoma (HCC).

Son T. Pham, Rowena A. Bull, James M. Bennett, William D. Rawlinson, Gregory J. Dore, Andrew R. Lloyd, Peter A. White – 29 October 2010 – Recent data indicate that multiple hepatitis C virus (HCV) infections (mixed infection, superinfection, and reinfection) are common among injection drug users (IDUs). In this study, we identified and characterized multiple HCV infection episodes among HCV‐seronegative IDU prison inmates (n = 488) enrolled in the Hepatitis C Incidence and Transmission Study cohort.

Henriette E. Meyer zu Schwabedissen, Kerstin Böttcher, Amarjit Chaudhry, Heyo K. Kroemer, Erin G. Schuetz, Richard B. Kim – 29 October 2010 – Organic anion transporting polypeptide 1B1 (OATP1B1) is a liver‐enriched transporter involved in the hepatocellular uptake of many endogenous molecules and several structurally divergent drugs in clinical use. Although OATP1B1 coding region polymorphisms are known to make an impact on substrate drug disposition in humans, little is known regarding the mechanisms underlying the transcriptional regulation of this transporter.

Yi‐Wen Huang, Jui‐Ting Hu, Sien‐Sing Yang – 29 October 2010

Mira El Chaar, Daniel Candotti, R. Anthony Crowther, Jean Pierre Allain – 29 October 2010 – Genotype D occult hepatitis B virus (HBV) infections (OBIs) have a high frequency of amino acid substitutions in the major hydrophilic region of the small surface protein (S protein). This possibly reflects an escape mutation mechanism to evade detection by the host immune system. Mutations may also impact the detection of hepatitis B surface antigen (HBsAg) by commercial assays.

Chian‐Feng Chen, En‐Chi Hsu, Kuen‐Tyng Lin, Pang‐Hsien Tu, Hung‐Wei Chang, Chin‐Hui Lin, Yann‐Jang Chen, De‐Leung Gu, Chi‐Hung Lin, Jer‐Yuarn Wu, Yuan‐Tsong Chen, Ming‐Ta Hsu, Yuh‐Shan Jou – 29 October 2010 – Recurrent cancer genome aberrations are indicators of residing crucial cancer genes. Although recent advances in genomic technologies have led to a global view of cancer genome aberrations, the identification of target genes and biomarkers from the aberrant loci remains difficult.

Ângelo Zambam de Mattos, Paulo Roberto Lerias de Almeida, Cristiane Valle Tovo, Angelo Alves de Mattos – 29 October 2010

Cheng‐Fu Xu, Chao‐Hui Yu, Lei Xu, Xiao‐Ying Sa, You‐Ming Li – 29 October 2010

Laura Kulik – 29 October 2010