Human hepatocarcinoma‐intestine‐pancreas/pancreatitis‐associated protein cures fas‐induced acute liver failure in mice by attenuating free‐radical damage in injured livers

Nicolas Moniaux, Haiyan Song, Marion Darnaud, Kévin Garbin, Michelle Gigou, Claudia Mitchell, Didier Samuel, Laure Jamot, Paul Amouyal, Gilles Amouyal, Christian Bréchot, Jamila Faivre – 19 November 2010 – Acute liver failure (ALF) is a rare syndrome with a difficult clinical management and a high mortality rate. During ALF, several molecular pathways governing oxidative stress and apoptosis are activated to induce massive tissue injury and suppress cell proliferation.

Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity

Evaggelia Liaskou, Marika Karikoski, Gary M. Reynolds, Patricia F. Lalor, Chris J. Weston, Nick Pullen, Marko Salmi, Sirpa Jalkanen, David H. Adams – 19 November 2010 – Primary sclerosing cholangitis (PSC) and autoimmune hepatitis are hepatic complications associated with inflammatory bowel disease (IBD). The expression of mucosal addressin cell adhesion molecule 1 (MAdCAM‐1) on mucosal endothelium is a prerequisite for the development of IBD, and it is also detected on the hepatic vessels of patients with liver diseases associated with IBD.

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