Emmanuel Boleslawski, Samia Ben Othman, Lynda Aoudjehane, Sandrine Chouzenoux, Olivier Scatton, Olivier Soubrane, Yvon Calmus, Nadira Delhem, Filomena Conti – 3 December 2010 – At present, no method is available for accurately monitoring the degree of immunosuppression induced by antirejection therapies. The aim of this study was to determine whether CD28 and CD38 expression by peripheral blood mononuclear cells could be useful in predicting the development of de novo malignancies after liver transplantation.

Philipp Dutkowski, Christian E. Oberkofler, Markus Béchir, Beat Müllhaupt, Andreas Geier, Dimitri A. Raptis, Pierre‐Alain Clavien – 3 December 2010 – We analyzed the first 100 patients who underwent liver transplantation by Model for End‐Stage Liver Disease (MELD) allocation, and compared the outcome of patients on the waiting list and after orthotopic liver transplantation with the last 100 patients who underwent transplantation prior to the introduction of the MELD system in July 2007.

Tomasz Kozlowski, Tara Rubinas, Volker Nickeleit, John Woosley, John Schmitz, Dana Collins, Paul Hayashi, Anthony Passannante, Kenneth Andreoni – 3 December 2010 – The importance of antibody‐mediated rejection (AMR) in ABO‐compatible liver transplantation is controversial. Here we report a prospective series of liver recipients with a preoperative positive crossmatch. To establish the diagnosis of AMR in liver recipients, the criteria described for kidney allografts were adopted.

Zhi‐Jun Zhu, Zhong‐Yang Shen, Wei Gao, Hong Zheng, Yong‐Lin Deng, Cheng Pan, Li‐Ying Sun, Zhi‐Gui Zeng, Ji‐San Sun – 29 November 2010 – Use of livers infected with Clonorchis sinensis as donor organs for transplantation is controversial because of the potential associated risks. The low availability of donor livers at Tianjin First Center Hospital since 2003 prompted us to undertake cadaveric liver transplantation in 14 patients using donor livers infected with C. sinensis.

29 November 2010

Jinoo Kim, Gi‐Young Ko, Kyu‐Bo Sung, Dong Il Gwon, Sung‐Gyu Lee, Kwang‐Mi Kim, Kyung‐Ah Kim, Hyun‐Ki Yoon – 29 November 2010 – This study evaluated the feasibility and efficacy of covered retrievable stent placement compared with drainage catheter placement for treating biliary anastomotic strictures following living donor liver transplantation (LDLT).

Noor Mohamed Jameel, Chinnasamy Thirunavukkarasu, Noriko Murase, Michael Cascio, John Prelich, Shuting Yang, Stephen A. K Harvey, Chandrashekhar R Gandhi – 29 November 2010 – Within the liver, reactive oxygen species produced by infiltrating blood cells and Kupffer cells (resident macrophages) can injure hepatocytes. We hypothesized that hepatocyte survival is influenced by the relatively small juxtaposed population of hepatic stellate cells (HSCs).

Vincent W. Keng, Barbara R. Tschida, Jason B. Bell, David A. Largaespada – 24 November 2010 – The mechanisms associated with hepatitis B virus (HBV)–induced hepatocellular carcinoma (HCC) remain elusive, and there are currently no well‐established animal models for studying this disease. Using the Sleeping Beauty transposon as a delivery system, we introduced an oncogenic component of HBV, the hepatitis B virus X (HBx) gene, into the livers of fumarylacetoacetate hydrolase (Fah) mutant mice via hydrodynamic tail vein injections.

Yue Wang, Yingjun Guo, Fang Wang, Shuhan Sun – 24 November 2010

Gisa Gerold, Charles M. Rice, Alexander Ploss – 23 November 2010 – Hepatitis C virus (HCV) naturally infects only humans and chimpanzees. The determinants responsible for this narrow species tropism are not well defined. Virus cell entry involves human scavenger receptor class B type I (SR‐BI), CD81, claudin‐1 and occludin. Among these, at least CD81 and occludin are utilized in a highly species‐specific fashion, thus contributing to the narrow host range of HCV.