Bile proteomic profiles differentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis

Tim O. Lankisch, Jochen Metzger, Ahmed A. Negm, Katja Voβkuhl, Eric Schiffer, Justyna Siwy, Tobias J. Weismüller, Andrea S. Schneider, Kathrin Thedieck, Ralf Baumeister, Petra Zürbig, Eva M. Weissinger, Michael P. Manns, Harald Mischak, Jochen Wedemeyer – 7 December 2010 – Early detection of malignant biliary tract diseases, especially cholangiocarcinoma (CC) in patients with primary sclerosing cholangitis (PSC), is very difficult and often comes too late to give the patient a therapeutic benefit. We hypothesize that bile proteomic analysis distinguishes CC from nonmalignant lesions.

Serum chemokine CXC ligand 10 (CXCL10) predicts fibrosis progression after liver transplantation for hepatitis C infection

Marie‐Luise Berres, Christian Trautwein, Maximilian Schmeding, Dennis Eurich, Frank Tacke, Marcus Bahra, Peter Neuhaus, Ulf P. Neumann, Hermann E. Wasmuth – 6 December 2010 – The recurrence of liver fibrosis after liver transplantation (LT) for hepatitis C virus (HCV) infection is responsible for graft loss and patient mortality. Although the contribution of the immune system to fibrosis recurrence is anticipated, systematic studies evaluating immune parameters as predictive markers of allograft fibrosis are lacking.

Gender‐specific differences in adipose distribution and adipocytokines influence adolescent nonalcoholic fatty liver disease

Oyekoya T. Ayonrinde, John K. Olynyk, Lawrence J. Beilin, Trevor A. Mori, Craig E. Pennell, Nicholas de Klerk, Wendy H. Oddy, Peter Shipman, Leon A. Adams – 6 December 2010 – Nonalcoholic fatty liver disease (NAFLD) is a predominantly adult‐diagnosed disorder. Knowledge regarding the epidemiology, phenotype, and metabolic risk factors, during adolescence is limited.

Relationship between the interleukin‐28b gene polymorphism and the histological severity of hepatitis C virus–induced graft inflammation and the response to antiviral therapy after liver transplantation

Dennis Eurich, Sabine Boas‐Knoop, Martin Ruehl, Maria Schulz, Esperanza D. Carrillo, Thomas Berg, Ruth Neuhaus, Peter Neuhaus, Ulf Peter Neumann, Marcus Bahra – 6 December 2010 – Up to 30% of liver transplants will develop graft cirrhosis within 5 years after liver transplantation (LT) due to recurrent HCV‐infection forwarding accelerated graft damage. Genetic variants of cytokines involved in the immune response may contribute to the degree of graft inflammation, fibrosis progression, and antiviral therapy outcome.

Up‐regulation of the fibroblast growth factor 8 subfamily in human hepatocellular carcinoma for cell survival and neoangiogenesis

Christine Gauglhofer, Sandra Sagmeister, Waltraud Schrottmaier, Carina Fischer, Chantal Rodgarkia‐Dara, Thomas Mohr, Stefan Stättner, Christoph Bichler, Daniela Kandioler, Fritz Wrba, Rolf Schulte‐Hermann, Klaus Holzmann, Michael Grusch, Brigitte Marian, Walter Berger, Bettina Grasl‐Kraupp – 6 December 2010 – Fibroblast growth factors (FGFs) and their high‐affinity receptors [fibroblast growth factor receptors (FGFRs)] contribute to autocrine and paracrine growth stimulation in several nonliver cancer entities.

Liver allograft antibody‐mediated rejection with demonstration of sinusoidal C4d staining and circulating donor‐specific antibodies

Tomasz Kozlowski, Tara Rubinas, Volker Nickeleit, John Woosley, John Schmitz, Dana Collins, Paul Hayashi, Anthony Passannante, Kenneth Andreoni – 3 December 2010 – The importance of antibody‐mediated rejection (AMR) in ABO‐compatible liver transplantation is controversial. Here we report a prospective series of liver recipients with a preoperative positive crossmatch. To establish the diagnosis of AMR in liver recipients, the criteria described for kidney allografts were adopted.

The model for end‐stage liver disease allocation system for liver transplantation saves lives, but increases morbidity and cost: a prospective outcome analysis

Philipp Dutkowski, Christian E. Oberkofler, Markus Béchir, Beat Müllhaupt, Andreas Geier, Dimitri A. Raptis, Pierre‐Alain Clavien – 3 December 2010 – We analyzed the first 100 patients who underwent liver transplantation by Model for End‐Stage Liver Disease (MELD) allocation, and compared the outcome of patients on the waiting list and after orthotopic liver transplantation with the last 100 patients who underwent transplantation prior to the introduction of the MELD system in July 2007.

CD28 expression by peripheral blood lymphocytes as a potential predictor of the development of de novo malignancies in long‐term survivors after liver transplantation

Emmanuel Boleslawski, Samia Ben Othman, Lynda Aoudjehane, Sandrine Chouzenoux, Olivier Scatton, Olivier Soubrane, Yvon Calmus, Nadira Delhem, Filomena Conti – 3 December 2010 – At present, no method is available for accurately monitoring the degree of immunosuppression induced by antirejection therapies. The aim of this study was to determine whether CD28 and CD38 expression by peripheral blood mononuclear cells could be useful in predicting the development of de novo malignancies after liver transplantation.

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