Hepatitis C trials that combine investigational agents with pegylated interferon should be stratified by interleukin‐28B genotype

Alexander J. Thompson, Andrew J. Muir, Mark S. Sulkowski, Keyur Patel, Hans L. Tillmann, Paul J. Clark, Susanna Naggie, Jacques Fellay, Dongliang Ge, Jeanette J. McCarthy, David B. Goldstein, John G. McHutchison – 23 November 2010

The balancing act of hepatocyte apoptosis

Nicholas A. Shackel – 23 November 2010 – The cell death receptor Fas plays a role in the establishment of fulminant hepatitis, a major cause of drug‐induced liver failure. Fas activation elicits extrinsic apoptotic and hepatoprotective signals; however, the mechanisms by which these signals are integrated during disease are unknown. Tissue inhibitor of metalloproteinases 3 (TIMP3) controls the critical sheddase a disintegrin and metalloproteinase 17 (ADAM17) and may dictate stress signaling.

Subscribe to