Septum transversum‐derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver

Kinji Asahina, Bin Zhou, William T. Pu, Hidekazu Tsukamoto – 14 December 2010 – The septum transversum mesenchyme (STM) signals to induce hepatogenesis from the foregut endoderm. Hepatic stellate cells (HSCs) are sinusoidal pericytes assumed to originate from the STM and participate in mesenchymal‐epithelial interaction in embryonic and adult livers. However, the developmental origin of HSCs remains elusive due to the lack of markers for STM and HSCs.

Loss of transforming growth factor β adaptor protein β‐2 spectrin leads to delayed liver regeneration in mice

Arun Thenappan, Vivek Shukla, Feras J. Abdul Khalek, Ying Li, Kirti Shetty, Pu Liu, Lu Li, Randy L. Johnson, Lynt Johnson, Lopa Mishra – 14 December 2010 – Liver regeneration, following partial hepatectomy (PHx), occurs through precisely controlled and synchronized cell proliferation, in which quiescent hepatocytes undergo one to two rounds of replication, with restoration of liver mass and function. We previously demonstrated that loss of the Smad3/4 adaptor protein β‐2 spectrin (β2SP) is associated with faster entry into S phase, and hepatocellular cancer formation.

Risk assessment of hepatitis B virus–related hepatocellular carcinoma development using liver stiffness measurement (FibroScan)

Kyu Sik Jung, Seung Up Kim, Sang Hoon Ahn, Young Nyun Park, Do Young Kim, Jun Yong Park, Chae Yoon Chon, Eun Hee Choi, Kwang‐Hyub Han – 14 December 2010 – Liver stiffness measurement (LSM) using FibroScan accurately assesses the degree of liver fibrosis and the risk of hepatocellular carcinoma (HCC) development in patients with chronic hepatitis C. This study investigated the usefulness of LSM as a predictor of HCC development in patients with chronic hepatitis B (CHB).

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