Innate immunity and primary biliary cirrhosis: Activated invariant natural killer T cells exacerbate murine autoimmune cholangitis and fibrosis

Si‐Jie Wu, Yao‐Hsu Yang, Koichi Tsuneyama, Patrick S.C. Leung, Petr Illarionov, M. Eric Gershwin, Ya‐Hui Chuang – 14 December 2010 – Murine models of autoimmunity allow the study of the earliest events in disease pathogenesis.

Hepatitis C virus receptors claudin‐1 and occludin after liver transplantation and influence on early viral kinetics

Laura Mensa, Gonzalo Crespo, Matthew J. Gastinger, Juraj Kabat, Sofía Pérez‐del‐Pulgar, Rosa Miquel, Suzanne U. Emerson, Robert H. Purcell, Xavier Forns – 14 December 2010 – Liver transplantation (LT) is a unique model to study hepatitis C virus (HCV) entry into hepatocytes. Recent in vitro studies suggest significant changes in the expression of the HCV receptors claudin‐1 and occludin after HCV infection.

Epithelial cell adhesion molecule (EpCAM) marks hepatocytes newly derived from stem/progenitor cells in humans

So‐Mi Yoon, Domniki Gerasimidou, Reiichiro Kuwahara, Prodromos Hytiroglou, Jeong Eun Yoo, Young Nyun Park, Neil D. Theise – 14 December 2010 – Epithelial cell adhesion molecule (EpCAM) is a surface marker on human hepatic stem/progenitor cells that is reported as absent on mature hepatocytes.

Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: mechanisms and effects on liver regeneration

Mariëlle Verweij, Tessa M. van Ginhoven, James R. Mitchell, Wim Sluiter, Sandra van den Engel, Henk P. Roest, Elham Torabi, Jan N. M. IJzermans, Jan H. J. Hoeijmakers, Ron W. F. de Bruin – 14 December 2010 – We show that brief periods of fasting induce functional changes similar to those induced by long‐term dietary restriction in mice, and these changes include protection from ischemia/reperfusion (I/R) injury. In this study, we investigated the mechanisms of protection induced by fasting, and we determined the effect on liver regeneration after partial hepatectomy.

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