Regulation of hepatic fat and glucose oxidation in rats with lipid‐induced hepatic insulin resistance

Tiago C. Alves, Douglas E. Befroy, Richard G. Kibbey, Mario Kahn, Roberto Codella, Rui A. Carvalho, Kitt Falk Petersen, Gerald I. Shulman – 11 January 2011 – Pyruvate dehydrogenase plays a critical role in the regulation of hepatic glucose and fatty acid oxidation; however, surprisingly little is known about its regulation in vivo. In this study we examined the individual effects of insulin and substrate availability on the regulation of pyruvate dehydrogenase flux (VPDH) to tricarboxylic acid flux (VTCA) in livers of awake rats with lipid‐induced hepatic insulin resistance.

Excess mortality in patients with advanced chronic hepatitis C treated with long‐term peginterferon

Adrian M. Di Bisceglie, Anne M. Stoddard, Jules L. Dienstag, Mitchell L. Shiffman, Leonard B. Seeff, Herbert L. Bonkovsky, Chihiro Morishima, Elizabeth C. Wright, Kristin K. Snow, William M. Lee, Robert J. Fontana, Timothy R. Morgan, Marc G. Ghany, for the HALT‐C Trial Group – 11 January 2011 – Chronic hepatitis C virus infection can cause chronic liver disease, cirrhosis and liver cancer.

Hepatitis B virus infection and risk of intrahepatic cholangiocarcinoma and non‐Hodgkin lymphoma: A cohort study of parous women in Taiwan

Chyng‐Wen Fwu, Yin‐Chu Chien, San‐Lin You, Kenrad E. Nelson, Gregory D. Kirk, Hsu‐Sung Kuo, Manning Feinleib, Chien‐Jen Chen – 10 January 2011 – Few studies have evaluated the risk of cancers other than hepatocellular carcinoma associated with hepatitis B virus (HBV) infection. This study aimed to estimate incidence rates of intrahepatic cholangiocarcinoma (ICC) and non‐Hodgkin lymphoma (NHL) and its major subtypes in a nationwide cohort of parous women and to assess their associations with chronic HBV infection.

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