Arterial blood flow predicts graft survival in liver transplant patients

Sebastian Pratschke, Georgios Meimarakis, Stephan Mayr, Christian Graeb, Markus Rentsch, Reinhard Zachoval, Christiane Josephine Bruns, Axel Kleespies, Karl‐Walter Jauch, Florian Loehe, Martin Kurt Angele – 10 January 2011 – Proper liver perfusion is essential for sufficient organ function after liver transplantation. The aim of this study was to determine the effects of portal and arterial blood flow on liver function and organ survival after liver transplantation.

Laboratory test results after living liver donation in the adult‐to‐adult living donor liver transplantation cohort study

James F. Trotter, Brenda W. Gillespie, Norah A. Terrault, Michael M. Abecassis, Robert M. Merion, Robert S. Brown, Kim M. Olthoff, Paul H. Hayashi, Carl L. Berg, Robert A. Fisher, James E. Everhart, and the Adult‐to‐Adult Living Donor Liver Transplantation Cohort Study Group – 10 January 2011 – Information on the long‐term health of living liver donors is incomplete. Because changes in standard laboratory tests may reflect the underlying health of donors, results before and after donation were examined in the Adult‐to‐Adult Living Donor Liver Transplantation Cohort Study (A2ALL).

Proteins ZNF198 and SUZ12 are down‐regulated in hepatitis B virus (HBV) X protein‐mediated hepatocyte transformation and in HBV replication

Wen‐Horng Wang, Leo L. Studach, Ourania M. Andrisani – 10 January 2011 – Chronic hepatitis B virus (HBV) infection is a major etiologic factor in hepatocellular carcinoma (HCC) pathogenesis, involving effects of chronic liver inflammation and of the weakly oncogenic HBV X protein (pX). pX‐mediated hepatocyte transformation requires Polo‐like kinase1 (Plk1) activity, but the mechanism is not fully understood.

Hepatic stellate cells regulate immune response by way of induction of myeloid suppressor cells in mice

Hong‐Shiue Chou, Ching‐Chuan Hsieh, Horng‐Ren Yang, Lianfu Wang, Yusuke Arakawa, Kathleen Brown, Qingyu Wu, Feng Lin, Marion Peters, John J. Fung, Lina Lu, Shiguang Qian – 10 January 2011 – Although organ transplants have been applied for decades, outcomes of somatic cell transplants remain disappointing, presumably due to lack of appropriate supporting stromal cells.

Occludin is regulated by epidermal growth factor receptor activation in brain endothelial cells and brains of mice with acute liver failure

Feng Chen, Tomohide Hori, Norifumi Ohashi, Ann‐Marie Baine, Christopher B. Eckman, Justin H. Nguyen – 10 January 2011 – Mechanisms of brain edema in acute liver failure (ALF) are not completely understood. We recently demonstrated that matrix metalloproteinase 9 (MMP‐9) induces significant alterations to occludin in brain endothelial cells in vitro and in brains of mice with experimental ALF (Hepatology 2009;50:1914).

Hepatitis B virus infection and risk of intrahepatic cholangiocarcinoma and non‐Hodgkin lymphoma: A cohort study of parous women in Taiwan

Chyng‐Wen Fwu, Yin‐Chu Chien, San‐Lin You, Kenrad E. Nelson, Gregory D. Kirk, Hsu‐Sung Kuo, Manning Feinleib, Chien‐Jen Chen – 10 January 2011 – Few studies have evaluated the risk of cancers other than hepatocellular carcinoma associated with hepatitis B virus (HBV) infection. This study aimed to estimate incidence rates of intrahepatic cholangiocarcinoma (ICC) and non‐Hodgkin lymphoma (NHL) and its major subtypes in a nationwide cohort of parous women and to assess their associations with chronic HBV infection.

Noncirrhotic presinusoidal portal hypertension is common in cystic fibrosis–associated liver disease

Peter Witters, Louis Libbrecht, Tania Roskams, Kris De Boeck, Lieven Dupont, Marijke Proesmans, François Vermeulen, Birgitta Strandvik, Anders Lindblad, Xavier Stéphenne, Etienne Sokal, Serge Gosseye, Sam Heye, Geert Maleux, Raymond Aerts, Diethard Monbaliu, Jacques Pirenne, Ilse Hoffman, Frederik Nevens, David Cassiman – 10 January 2011

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