Martin Wagner, Gernot Zollner, Michael Trauner – 12 January 2011 – Nuclear receptors are ligand‐activated transcriptional regulators of several key aspects of hepatic physiology and pathophysiology. As such, nuclear receptors control a large variety of metabolic processes including hepatic lipid metabolism, drug disposition, bile acid homeostasis, as well as liver regeneration, inflammation, fibrosis, cell differentiation, and tumor formation. Derangements of nuclear receptor regulation and genetic variants may contribute to the pathogenesis and progression of liver diseases.

12 January 2011

12 January 2011

John M. Vierling – 11 January 2011

Melania Manco, Anna Alisi, Antonella Mosca, Valerio Nobili – 11 January 2011

Adrian M. Di Bisceglie, Anne M. Stoddard, Jules L. Dienstag, Mitchell L. Shiffman, Leonard B. Seeff, Herbert L. Bonkovsky, Chihiro Morishima, Elizabeth C. Wright, Kristin K. Snow, William M. Lee, Robert J. Fontana, Timothy R. Morgan, Marc G. Ghany, for the HALT‐C Trial Group – 11 January 2011 – Chronic hepatitis C virus infection can cause chronic liver disease, cirrhosis and liver cancer.

Elsa Solà, Sabela Lens, Mónica Guevara, Pere Ginès – 11 January 2011

Tetsuji Fujita – 11 January 2011

Jeff Fidler, David Hough – 11 January 2011

Tiago C. Alves, Douglas E. Befroy, Richard G. Kibbey, Mario Kahn, Roberto Codella, Rui A. Carvalho, Kitt Falk Petersen, Gerald I. Shulman – 11 January 2011 – Pyruvate dehydrogenase plays a critical role in the regulation of hepatic glucose and fatty acid oxidation; however, surprisingly little is known about its regulation in vivo. In this study we examined the individual effects of insulin and substrate availability on the regulation of pyruvate dehydrogenase flux (VPDH) to tricarboxylic acid flux (VTCA) in livers of awake rats with lipid‐induced hepatic insulin resistance.