Utilization of elderly donors in living donor liver transplantation: When more is less?

Murat Dayangac, C. Burcin Taner, Onur Yaprak, Tolga Demirbas, Deniz Balci, Cihan Duran, Yildiray Yuzer, Yaman Tokat – 25 January 2011 – An accepted definition of donor exclusion criteria has not been established for living donor liver transplantation (LDLT). The use of elderly donors to expand the living donor pool raises ethical concerns about donor safety. The aims of this study were (1) the comparison of the postoperative outcomes of living liver donors by age (≥50 versus <50 years) and (2) the evaluation of the impact of the extent of right hepatectomy on donor outcomes.

Effect of remote ischemic preconditioning on liver ischemia/reperfusion injury using a new mouse model

Mahmoud Abu‐Amara, Shi Yu Yang, Alberto Quaglia, Peter Rowley, Niteen Tapuria, Alexander M. Seifalian, Barry J. Fuller, Brian R. Davidson – 20 January 2011 – Ischemic preconditioning of remote organs (RIPC) reduces liver ischemia/reperfusion (IR) injury in the rabbit and rat. Mice are the only species available with a large number of transgenic strains. This study describes development and validation of a mouse model of hindlimb RIPC that attenuates liver IR injury.

Predictors of cardiovascular events after liver transplantation: A role for pretransplant serum troponin levels

Elizabeth Coss, Kymberly D. S. Watt, Rachel Pedersen, Ross Dierkhising, Julie K. Heimbach, Michael R. Charlton – 20 January 2011 – Cardiovascular complications are major causes of morbidity and mortality after liver transplantation. Identifying candidates at highest risk of postoperative complications is a cornerstone of optimizing outcomes and utility.

Role of endothelial nitric oxide synthase in remote ischemic preconditioning of the mouse liver

Mahmoud Abu‐Amara, Shi Yu Yang, Alberto Quaglia, Peter Rowley, Barry Fuller, Alexander Seifalian, Brian Davidson – 19 January 2011 – Hindlimb remote ischemic preconditioning (RIPC) reduces liver ischemia/reperfusion (IR) injury in wild‐type mice. The underlying mechanisms of RIPC are currently unknown. In this study, we investigated the role of endothelial nitric oxide synthase (eNOS) in mediating the protective effects of RIPC.

Complementary role of vitamin D deficiency and the interleukin‐28B rs12979860 C/T polymorphism in predicting antiviral response in chronic hepatitis C

Davide Bitetto, Giovanna Fattovich, Carlo Fabris, Elisa Ceriani, Edmondo Falleti, Ezio Fornasiere, Michela Pasino, Donatella Ieluzzi, Annarosa Cussigh, Sara Cmet, Mario Pirisi, Pierluigi Toniutto – 19 January 2011 – The widely accepted interleukin‐28B (IL‐28B) rs12979860 C/T polymorphism and the more recently proposed vitamin D serum concentration are two novel predictors of the response to antiviral treatment in chronic hepatitis C virus (HCV) infection.

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