Preoperative estimation of the liver graft weight in adult right lobe living donor liver transplantation using maximal portal vein diameters

Frank Wang, Kuang‐Tse Pan, Sung‐Yu Chu, Kun‐Ming Chan, Hong‐Shiue Chou, Ting‐Jung Wu, Wei‐Chen Lee – 19 January 2011 – An accurate preoperative estimate of the graft weight is vital to avoid small‐for‐size syndrome in the recipient and ensure donor safety after adult living donor liver transplantation (LDLT). Here we describe a simple method for estimating the graft volume (GV) that uses the maximal right portal vein diameter (RPVD) and the maximal left portal vein diameter (LPVD).

Reticulon 4B (Nogo‐B) is a novel regulator of hepatic fibrosis

Dahai Zhang, Teruo Utsumi, Hui‐Chun Huang, Lili Gao, Panjamaporn Sangwung, Chuhan Chung, Kazunori Shibao, Kohji Okamoto, Koji Yamaguchi, Roberto J. Groszmann, Levente Jozsef, Zhengrong Hao, William C. Sessa, Yasuko Iwakiri – 19 January 2011 – Nogo‐B, also known as Reticulon 4B, plays important roles in vascular injuries. Its function in the liver is not understood. The aim of this study was to characterize Nogo‐B in liver fibrosis and cirrhosis. Nogo‐B distribution was assessed in normal and cirrhotic human liver sections.

Comparison of radiofrequency ablation and transarterial chemoembolization for hepatocellular carcinoma within the Milan criteria: A propensity score analysis

Chia‐Yang Hsu, Yi‐Hsiang Huang, Yi‐You Chiou, Chien‐Wei Su, Han‐Chieh Lin, Rheun‐Chuan Lee, Jen‐Huey Chiang, Teh‐Ia Huo, Fa‐Yauh Lee, Shou‐Dong Lee – 19 January 2011 – Radiofrequency ablation (RFA) and transarterial chemoembolization (TACE) are used to treat hepatocellular carcinoma (HCC). This study was designed to compare the long‐term survival of HCC patients within the Milan criteria who underwent RFA or TACE. In all, 315 RFA patients and 215 TACE patients with HCC within the Milan criteria were analyzed. Propensity scores were generated to select matched patients.

Assessment of a chloride‐poor versus a chloride‐containing version of a modified histidine‐tryptophan‐ketoglutarate solution in a rat liver transplantation model

Christian D. Fingas, Shengli Wu, Yanli Gu, Jeremias Wohlschlaeger, André Scherag, Uta Dahmen, Andreas Paul, Herbert de Groot, Ursula Rauen – 19 January 2011 – Recent in vitro studies of cold‐induced cell injury have revealed the detrimental effects of extracellular chloride on cold‐stored isolated rat hepatocytes; however, its influence on endothelial cells is beneficial.

A randomized, controlled study of treatment for alcohol dependence in patients awaiting liver transplantation

Robert M. Weinrieb, Deborah H.A. Van Horn, Kevin G. Lynch, Michael R. Lucey – 14 January 2011 – Alcohol is the second most common cause of cirrhosis necessitating liver transplantation in the United States, yet rates of posttransplant drinking approach 50% and no controlled clinical trials of alcoholism treatment exist in this population. Eligible patients were randomly assigned to receive Motivational Enhancement Therapy (MET), or referral to local treatment sources (“treatment as usual” [TAU]). Addictive behavior, mood states, and general health were compared.

Operational tolerance: Past lessons and future prospects

Josh Levitsky – 14 January 2011 – Every liver transplant (LT) center has had patients who either self‐discontinue immunosuppressive (IS) therapy or are deliberately withdrawn due to a research protocol or clinical concern (ie, lymphoproliferative disorder [LPD], overwhelming infection). This is understandable because maintenance IS therapy, particularly calcineurin inhibitors (CNI), is associated with significant cost, side effects, and considerable long‐term morbidity and mortality.

Development of a disease‐specific questionnaire to measure health‐related quality of life in liver transplant recipients

Sammy Saab, Vivian Ng, Carmen Landaverde, Sung‐Jae Lee, W. Scott Comulada, Jennifer Arevalo, Francisco Durazo, Steven‐Huy Han, Zobari Younossi, Ronald W. Busuttil – 14 January 2011 – Currently, no disease‐targeted instrument is available for measuring health‐related quality of life (HRQOL) in liver transplant recipients. We developed and tested a post–liver transplant quality of life (pLTQ) instrument. Item selection for the pLTQ instrument was based on responses from liver transplant recipients, 12 liver experts, and a literature search.

Subscribe to