Lineage tracing demonstrates no evidence of cholangiocyte epithelial‐to‐mesenchymal transition in murine models of hepatic fibrosis

Andrew S. Chu, Rosalyn Diaz, Jia‐Ji Hui, Kilangsungla Yanger, Yiwei Zong, Gianfranco Alpini, Ben Z. Stanger, Rebecca G. Wells – 27 January 2011 – Whether or not cholangiocytes or their hepatic progenitors undergo an epithelial‐to‐mesenchymal transition (EMT) to become matrix‐producing myofibroblasts during biliary fibrosis is a significant ongoing controversy.

Liver transplantation for propionic acidemia in children

Roshni Vara, Charles Turner, Helen Mundy, Nigel D. Heaton, Mohammed Rela, Giorgina Mieli‐Vergani, Mike Champion, Nedim Hadzic – 25 January 2011 – Propionic acidemia (PA) is a rare inherited disorder of branched chain amino acid metabolism; despite improvements in conventional medical management, the long‐term outcome remains disappointing. Liver transplantation (LT) has been proposed to minimize the risk of further metabolic decompensations and to improve the quality of life. We performed a retrospective review of all children with PA who underwent LT between 1987 and 2008.

Utilization of elderly donors in living donor liver transplantation: When more is less?

Murat Dayangac, C. Burcin Taner, Onur Yaprak, Tolga Demirbas, Deniz Balci, Cihan Duran, Yildiray Yuzer, Yaman Tokat – 25 January 2011 – An accepted definition of donor exclusion criteria has not been established for living donor liver transplantation (LDLT). The use of elderly donors to expand the living donor pool raises ethical concerns about donor safety. The aims of this study were (1) the comparison of the postoperative outcomes of living liver donors by age (≥50 versus <50 years) and (2) the evaluation of the impact of the extent of right hepatectomy on donor outcomes.

Effect of remote ischemic preconditioning on liver ischemia/reperfusion injury using a new mouse model

Mahmoud Abu‐Amara, Shi Yu Yang, Alberto Quaglia, Peter Rowley, Niteen Tapuria, Alexander M. Seifalian, Barry J. Fuller, Brian R. Davidson – 20 January 2011 – Ischemic preconditioning of remote organs (RIPC) reduces liver ischemia/reperfusion (IR) injury in the rabbit and rat. Mice are the only species available with a large number of transgenic strains. This study describes development and validation of a mouse model of hindlimb RIPC that attenuates liver IR injury.

Predictors of cardiovascular events after liver transplantation: A role for pretransplant serum troponin levels

Elizabeth Coss, Kymberly D. S. Watt, Rachel Pedersen, Ross Dierkhising, Julie K. Heimbach, Michael R. Charlton – 20 January 2011 – Cardiovascular complications are major causes of morbidity and mortality after liver transplantation. Identifying candidates at highest risk of postoperative complications is a cornerstone of optimizing outcomes and utility.

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