Outcomes of adult living donor liver transplantation: Comparison of the adult‐to‐adult living donor liver transplantation cohort study and the national experience

Kim M. Olthoff, Michael M. Abecassis, Jean C. Emond, Igal Kam, Robert M. Merion, Brenda W. Gillespie, Lan Tong, the Adult‐to‐Adult Living Donor Liver Transplantation Cohort Study Group – 25 February 2011 – The study objectives were to determine whether the findings of the Adult‐to‐Adult Living Donor Liver Transplantation Cohort Study (A2ALL) reflect the U.S. national experience and to define risk factors for patient mortality and graft loss in living donor liver transplantation (LDLT).

Paneth cell‐derived interleukin‐17A causes multiorgan dysfunction after hepatic ischemia and reperfusion injury

Sang Won Park, Mihwa Kim, Kevin M. Brown, Vivette D. D'Agati, H. Thomas Lee – 25 February 2011 – Hepatic ischemia and reperfusion (IR) injury is a major clinical problem that leads to frequent extrahepatic complications including intestinal dysfunction and acute kidney injury (AKI). In this study we aimed to determine the mechanisms of hepatic IR‐induced extrahepatic organ dysfunction. Mice subjected to 60 minutes of hepatic IR not only developed severe hepatic injury but also developed significant AKI and small intestinal injury.

Sorafenib inhibits transforming growth factor β1‐Mediated Epithelial‐Mesenchymal Transition and apoptosis in mouse hepatocytes

Yue‐Lei Chen, Jing Lv, Xiao‐Lei Ye, Ming‐Yu Sun, Qin Xu, Cheng‐Hai Liu, Li‐Hua Min, Hui‐Ping Li, Ping Liu, Xiaoyan Ding – 25 February 2011 – Epithelial‐mesenchymal transition (EMT) is a physiological process that has been recognized to occur during the progression of an increasingly large number of human diseases, including liver fibrosis, cirrhosis, and hepatocellular carcinoma.

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William Sievert, Gregory J. Dore, Stuart K. Roberts, On behalf of the CHARIOT Study Group – 25 February 2011

Role of the coinhibitory receptor cytotoxic T lymphocyte antigen‐4 on apoptosis‐Prone CD8 T cells in persistent hepatitis B virus infection

Anna Schurich, Pooja Khanna, A. Ross Lopes, Ki Jun Han, Dimitra Peppa, Lorenzo Micco, Gaia Nebbia, Patrick T.F. Kennedy, Anna‐Maria Geretti, Geoffrey Dusheiko, Mala K. Maini – 25 February 2011 – An excess of coinhibitory signals has been proposed to drive the T‐cell exhaustion characteristic of persistent viral infections. In this study we examined the contribution of the coinhibitory receptor cytotoxic T lymphocyte antigen‐4 (CTLA‐4) to CD8 T cell tolerance in chronic hepatitis B virus (HBV) infection (CHB).

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