New staging system and a registry for perihilar cholangiocarcinoma

Michelle L. DeOliveira, Richard D. Schulick, Yuji Nimura, Charles Rosen, Gregory Gores, Peter Neuhaus, Pierre‐Alain Clavien – 11 February 2011 – Perihilar cholangiocarcinoma is one of the most challenging diseases with poor overall survival. The major problem for anyone trying to convincingly compare studies among centers or over time is the lack of a reliable staging system. The most commonly used system is the Bismuth‐Corlette classification of bile duct involvement, which, however, does not include crucial information such as vascular encasement and distant metastases.

Loss of phosphatase and tensin homolog enhances cell invasion and migration through aKT/Sp‐1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance

Karen Man‐Fong Sze, Kris Lai‐Ting Wong, Glanice Kin‐Yan Chu, Joyce Man‐Fong Lee, Tai‐On Yau, Irene Oi‐Lin Ng – 11 February 2011 – Phosphatase and tensin homolog (PTEN) is frequently inactivated in cancers and is associated with advanced stages of cancers or metastasis. However, the molecular mechanism of PTEN in hepatocellular carcinoma (HCC) metastasis is unclear. In this study, we found frequent (47.5%, n = 40) protein underexpression of PTEN in human HCCs compared with their corresponding nontumorous livers.

Drug‐induced cholestasis

Manmeet S. Padda, Mayra Sanchez, Abbasi J. Akhtar, James L. Boyer – 11 February 2011 – Recent progress in understanding the molecular mechanisms of bile formation and cholestasis have led to new insights into the pathogenesis of drug‐induced cholestasis. This review summarizes their variable clinical presentations, examines the role of transport proteins in hepatic drug clearance and toxicity, and addresses the increasing importance of genetic determinants, as well as practical aspects of diagnosis and management. (HEPATOLOGY 2011;)

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