Bharath Nath, Ivan Levin, Timea Csak, Jan Petrasek, Christian Mueller, Karen Kodys, Donna Catalano, Pranoti Mandrekar, Gyongyi Szabo – 3 March 2011 – Chronic alcohol causes hepatic steatosis and liver hypoxia. Hypoxia‐regulated hypoxia‐inducible factor 1‐α, (HIF‐1α) may regulate liporegulatory genes, but the relationship of HIF‐1 to steatosis remains unknown. We investigated HIF‐1α in alcohol‐induced hepatic lipid accumulation.

Jean‐Michel Pawlotsky – 3 March 2011 – Current treatment of chronic hepatitis C virus (HCV) infection is based on the combination of pegylated interferon‐α and ribavirin. The recent development of direct‐acting antiviral (DAA) molecules that are active on HCV, together with in vitro and in vivo studies showing that these drugs may lead to the selection of resistant viruses if administered alone, has raised concerns that resistance may undermine therapy based on DAAs.

3 March 2011

Fabio Marongiu, Roberto Gramignoli, Kenneth Dorko, Toshio Miki, Aarati R. Ranade, Maria Paola Serra, Silvia Doratiotto, Marcella Sini, Shringi Sharma, Keitaro Mitamura, Tiffany L. Sellaro, Veysel Tahan, Kristen J. Skvorak, Ewa C. S. Ellis, Stephen F. Badylak, Julio C. Davila, Ronald Hines, Ezio Laconi, Stephen C. Strom – 3 March 2011 – Hepatocyte transplantation to treat liver disease is largely limited by the availability of useful cells.

Jean‐Charles Duclos‐Vallée, René Adam, Eric Vibert, Didier Samuel – 28 February 2011

Luca Valenti, Massimo Colombo, Silvia Fargion – 28 February 2011

Tao Liu, Chunmei Zhang, Yingjie Wang – 28 February 2011

Zobair M. Younossi, Maria Stepanova, Nila Rafiq, Hala Makhlouf, Zahra Younoszai, Ritambhara Agrawal, Zachary Goodman – 28 February 2011 – Since the initial description of nonalcoholic steatohepatitis (NASH), several sets of pathologic criteria for its diagnosis have been proposed. However, their interprotocol agreement and ability to predict long‐term liver‐related mortality (LRM) have not been demonstrated. In this study, we examined patients with biopsy‐proven nonalcoholic fatty liver disease (NAFLD) for whom liver biopsy slides and clinical and mortality data were available.

Wei Qiu, Jing Zhang, Mark J. Dekker, Huajin Wang, Ju Huang, John H. Brumell, Khosrow Adeli – 28 February 2011 – Induction of endoplasmic reticulum (ER) stress was previously shown to impair hepatic apolipoprotein B100 (apoB) production by enhancing cotranslational and posttranslational degradation of newly synthesized apoB. Here, we report the involvement of autophagy in ER stress–induced degradation of apoB and provide evidence for a significant role of autophagy in regulating apoB biogenesis in primary hepatocyte systems.

Jiabin Yan, Zuliang Jie, Lifei Hou, Joao L. Wanderley, Lynn Soong, Shalini Gupta, Suimin Qiu, Tehsheng Chan, Jiaren Sun – 28 February 2011 – The healthy adult human liver expresses low levels of major histocompatibility complex class II (MHC II) and undetectable levels of immune costimulatory molecules. However, high levels of MHC II, CD40, and B7 family molecules are expressed in the activated Kupffer cells and hepatocytes of patients with viral hepatitis. The precise role of these molecules in viral clearance and immune‐mediated liver injury is not well understood.