Mylène Sebagh, Daniel Azoulay, Bruno Roche, Emir Hoti, Vincent Karam, Elina Teicher, Laurence Bonhomme‐Faivre, Faouzi Saliba, Jean‐Charles Duclos‐Vallée, Didier Samuel – 23 February 2011 – After liver transplantation (LT), hepatic veno‐occlusive disease (VOD), which is also known as sinusoidal obstruction syndrome (SOS), has been reported initially in relation to azathioprine use and subsequently in relation to acute rejection (AR). Isolated veno‐occlusive disease (iVOD)/SOS raises some questions about its significance and especially its treatment.

Valerio Nobili, Anna Alisi, Jean de Ville de Goyet – 23 February 2011

Stefano Ginanni Corradini, Maria Antonella Burza, Antonio Molinaro, Stefano Romeo – 23 February 2011

Robert J. Clifford, Kenneth H. Buetow – 15 February 2011

Sven Haufe, Stefan Engeli, Petra Kast, Jana Böhnke, Wolfgang Utz, Verena Haas, Mario Hermsdorf, Anja Mähler, Susanne Wiesner, Andreas L. Birkenfeld, Henrike Sell, Christoph Otto, Heidrun Mehling, Friedrich C. Luft, Juergen Eckel, Jeanette Schulz‐Menger, Michael Boschmann, Jens Jordan – 15 February 2011 – Obesity‐related hepatic steatosis is a major risk factor for metabolic and cardiovascular disease. Fat reduced hypocaloric diets are able to relieve the liver from ectopically stored lipids.

Amar Deep Sharma, Nidhi Narain, Eva‐Maria Händel, Marcus Iken, Nishant Singhal, Toni Cathomen, Michael P. Manns, Hans R. Schöler, Michael Ott, Tobias Cantz – 15 February 2011 – Death receptor‐mediated apoptosis of hepatocytes contributes to hepatitis and fulminant liver failure. MicroRNAs (miRNAs), 19‐25 nucleotide‐long noncoding RNAs, have been implicated in the posttranscriptional regulation of the various apoptotic pathways. Here we report that global loss of miRNAs in hepatic cells leads to increased cell death in a model of FAS/CD95 receptor‐induced apoptosis.

Elizabeth M. Brunt, Gregory Gores – 14 February 2011

Christophe Van Steenkiste, Jordi Ribera, Anja Geerts, Montse Pauta, Sònia Tugues, Christophe Casteleyn, Louis Libbrecht, Kim Olievier, Ben Schroyen, Hendrik Reynaert, Leo A. van Grunsven, Bram Blomme, Stephanie Coulon, Femke Heindryckx, Martine De Vos, Jean Marie Stassen, Stefan Vinckier, Jose Altamirano, Ramón Bataller, Peter Carmeliet, Hans Van Vlierberghe, Isabelle Colle, Manuel Morales‐Ruiz – 14 February 2011 – Placental growth factor (PlGF) is associated selectively with pathological angiogenesis, and PlGF blockade does not affect the healthy vasculature.

Tahany Awad, Kristian Thorlund, Goran Hauser, Davor Stimac, Mahasen Mabrouk, Christian Gluud – 14 February 2011

Tsutomu Matsubara, Naoki Tanaka, Andrew D. Patterson, Joo‐Youn Cho, Kristopher W. Krausz, Frank J. Gonzalez – 14 February 2011 – Lithocholic acid (LCA) is an endogenous compound associated with hepatic toxicity during cholestasis. LCA exposure in mice resulted in decreased serum lysophosphatidylcholine (LPC) and sphingomyelin levels due to elevated lysophosphatidylcholine acyltransferase (LPCAT) and sphingomyelin phosphodiesterase (SMPD) expression.