Carolien Out, Jurre Hageman, Vincent W. Bloks, Han Gerrits, Maarten D. Sollewijn Gelpke, Trijnie Bos, Rick Havinga, Martin J. Smit, Folkert Kuipers, Albert K. Groen – 9 March 2011 – Liver receptor homolog‐1 (LRH‐1) is a nuclear receptor that controls a variety of metabolic pathways. In cultured cells, LRH‐1 induces the expression of CYP7A1 and CYP8B1, key enzymes in bile salt synthesis. However, hepatic Cyp7a1 mRNA levels were not reduced upon hepatocyte‐specific Lrh‐1 deletion in mice. The reason for this apparent paradox has remained elusive.

Hany A. Omar, Chih‐Chien Chou, Lisa D. Berman‐Booty, Yihui Ma, Jui‐Hsiang Hung, Dasheng Wang, Takayuki Kogure, Tushar Patel, Luigi Terracciano, Natarajan Muthusamy, John C. Byrd, Samuel K. Kulp, Ching‐Shih Chen – 9 March 2011 – Accumulating evidence suggests the therapeutic potential of the immunosuppressive agent FTY720 (fingolimod) in hepatocellular carcinoma (HCC).

María V. Espelt, Diego O. Croci, María L. Bacigalupo, Pablo Carabias, Malena Manzi, María T. Elola, Marina C. Muñoz, Fernando P. Dominici, Carlota Wolfenstein‐Todel, Gabriel A. Rabinovich, María F. Troncoso – 9 March 2011 – Galectin‐1 (Gal‐1), a widely expressed β‐galactoside–binding protein, exerts pleiotropic biological functions. Gal‐1 is up‐regulated in hepatocarcinoma cells, although its role in liver pathophysiology remains uncertain. We investigated the effects of Gal‐1 on HepG2 hepatocellular carcinoma (HCC) cell adhesion and polarization.

Marta A. Kowalik, Christian Saliba, Monica Pibiri, Andrea Perra, Giovanna M. Ledda‐Columbano, Ivana Sarotto, Elena Ghiso, Silvia Giordano, Amedeo Columbano – 9 March 2011

Sébastien Anthérieu, Alexandra Rogue, Bernard Fromenty, André Guillouzo, Marie‐Anne Robin – 9 March 2011 – Drug‐induced liver injury occurs in general after several weeks and is often unpredictable. It is characterized by a large spectrum of lesions that includes steatosis and phospholipidosis. Many drugs such as amiodarone and tetracycline have been reported to cause phospholipidosis and/or steatosis. In this study, acute and chronic hepatic effects of these two drugs were investigated using well‐differentiated human hepatoma HepaRG cells.

Peter J. Lewindon, Grant A. Ramm – 9 March 2011

Raymund R. Razonable, James Y. Findlay, Aisling O'Riordan, S. Gordon Burroughs, R. Mark Ghobrial, Banwari Agarwal, Andrew Davenport, Michael Gropper – 7 March 2011 – The majority of patients who undergo liver transplantation (LT) spend some time in the intensive care unit during the postoperative period. For some, this is an expected part of the immediate posttransplant recovery period, whereas for others, the stay is more prolonged because of preexisting conditions, intraoperative events, or postoperative complications.

Mark A. McNiven, Carol A. Casey – 7 March 2011

Peter Nissen Bjerring, Martin Eefsen, Fin Stolze Larsen, William Bernal, Julia Wendon – 7 March 2011 – Intravenous infusion of magnesium sulfate prevents seizures in patients with eclampsia and brain edema after traumatic brain injury. Neuroprotection is achieved by controlling cerebral blood flow (CBF), intracranial pressure, neuronal glutamate release, and aquaporin‐4 (Aqp4) expression. These factors are also thought to be involved in the development of brain edema in acute liver failure.

Patrizia Burra, Giacomo Germani, Francesca Gnoato, Silvia Lazzaro, Francesco Paolo Russo, Umberto Cillo, Marco Senzolo – 7 March 2011 – Adherence to a medical regimen has been defined as the extent to which a patient's behavior coincides with clinical prescriptions. In liver transplant patients, adherence to immunosuppressive therapy and to medical indications in general is crucial for short‐ and long‐term outcomes.