Complement component 4d immunostaining in liver allografts of patients with de novo immune hepatitis

Isabel Aguilera, José Manuel Sousa, Francisco Gavilan, Lourdes Gomez, Antonia Álvarez‐Márquez, Antonio Núñez‐Roldán – 21 March 2011 – De novo immune hepatitis (DNIH) is a form of late graft dysfunction after liver transplantation. The fine mechanisms leading to the development of DNIH are not known, and whether this hepatitis is a form of rejection or a result of an auto/alloimmune injury has not been established.

Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9

Marcel Janse, Laetitia E. Lamberts, Lude Franke, Soumya Raychaudhuri, Eva Ellinghaus, Kirsten Muri Boberg, Espen Melum, Trine Folseraas, Erik Schrumpf, Annika Bergquist, Einar Björnsson, Jingyuan Fu, Harm Jan Westra, Harry J.M. Groen, Rudolf S.N. Fehrmann, Joanna Smolonska, Leonard H. van den Berg, Roel A. Ophoff, Robert J. Porte, Tobias J. Weismüller, Jochen Wedemeyer, Christoph Schramm, Martina Sterneck, Rainer Günther, Felix Braun, Severine Vermeire, Liesbet Henckaerts, Cisca Wijmenga, Cyriel Y. Ponsioen, Stefan Schreiber, Tom H. Karlsen, Andre Franke, Rinse K.

Delayed‐onset caspase‐dependent massive hepatocyte apoptosis upon fas activation in bak/bax‐deficient mice

Hayato Hikita, Tetsuo Takehara, Takahiro Kodama, Satoshi Shimizu, Minoru Shigekawa, Atsushi Hosui, Takuya Miyagi, Tomohide Tatsumi, Hisashi Ishida, Wei Li, Tatsuya Kanto, Naoki Hiramatsu, Shigeomi Shimizu, Yoshihide Tsujimoto, Norio Hayashi – 21 March 2011 – The proapoptotic Bcl‐2 family proteins Bak and Bax serve as an essential gateway to the mitochondrial pathway of apoptosis.

Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice

Timea Csak, Angela Dolganiuc, Karen Kodys, Bharath Nath, Jan Petrasek, Shashi Bala, Dora Lippai, Gyongyi Szabo – 21 March 2011 – Mitochondrial dysfunction is a pathogenic feature of nonalcoholic steatohepatitis (NASH). NASH complicates hepatotropic viral disease. The mitochondrial antiviral signaling protein (MAVS) is the adapter of helicase receptors involved in sensing double‐stranded RNA (dsRNA). We hypothesized that impaired MAVS function may contribute to insufficient antiviral response and liver damage in steatohepatitis.

Genetic variation in interleukin 28B with respect to vertical transmission of hepatitis C virus and spontaneous clearance in HCV‐infected children

Ángeles Ruiz‐Extremera, José Antonio Muñoz‐Gámez, María Angustias Salmerón‐Ruiz, Paloma Muñoz de Rueda, Rosa Quiles‐Pérez, Ana Gila‐Medina, Jorge Casado, Ana Belén Martín, Laura Sanjuan‐Nuñez, Ángel Carazo, Esther José Pavón, Esther Ocete‐Hita, Josefa León, Javier Salmerón – 16 March 2011 – The vertical transmission of hepatitis C virus (HCV‐VT) is a major route of HCV infection in children, but the risk factors remain incompletely understood. This study analyzed the role of interleukin 28B (IL28B) in HCV‐VT and in the spontaneous clearance of HCV among infected infants.

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