p19ARF/p14ARF controls oncogenic functions of signal transducer and activator of transcription 3 in hepatocellular carcinoma

Doris Schneller, Georg Machat, Alexandra Sousek, Verena Proell, Franziska van Zijl, Gudrun Zulehner, Heidemarie Huber, Markus Mair, Markus K. Muellner, Sebastian M.B. Nijman, Robert Eferl, Richard Moriggl, Wolfgang Mikulits – 30 March 2011 – Signal transducer and activator of transcription 3 (Stat3) is activated in a variety of malignancies, including hepatocellular carcinoma (HCC). Activation of Ras occurs frequently at advanced stages of HCC by aberrant signaling through growth factor receptors or inactivation of effectors negatively regulating Ras signaling.

Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion

Danijela Petrovic, Zania Stamataki, Eugene Dempsey, Lucy Golden‐Mason, Michael Freeley, Derek Doherty, David Prichard, Catherine Keogh, Jennifer Conroy, Siobhan Mitchell, Yuri Volkov, Jane A. McKeating, Cliona O'Farrelly, Dermot Kelleher, Aideen Long – 30 March 2011 – T cell activation and the resultant production of interleukin (IL‐2) is a central response of the adaptive immune system to pathogens, such as hepatitis C virus (HCV). HCV uses several mechanisms to evade both the innate and adaptive arms of the immune response.

Mixed hepatocellular cholangiocarcinoma and intrahepatic cholangiocarcinoma in patients undergoing transplantation for hepatocellular carcinoma

Gonzalo Sapisochin, Nicholas Fidelman, John P. Roberts, Francis Y. Yao – 24 March 2011 – Mixed hepatocellular cholangiocarcinoma (HCC‐CC) and intrahepatic cholangiocarcinoma (I‐CC) are increasingly being reported in patients with cirrhosis.

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