Hepatitis B virus quasispecies in hepatic and extrahepatic viral reservoirs in liver transplant recipients on prophylactic therapy

Carla S. Coffin, Patricia M. Mulrooney‐Cousins, Guido van Marle, John P. Roberts, Tomasz I. Michalak, Norah A. Terrault – 1 April 2011 – The characterization of hepatitis B virus (HBV) quasispecies in different compartments in liver transplant (LT) recipients may be helpful in optimizing prophylaxis regimens. The aims of this study were to evaluate liver, peripheral blood mononuclear cells (PBMC), and plasma samples for HBV and to compare the quasispecies in hepatic and extrahepatic sites in LT recipients on long‐term prophylaxis.

Association of hepatic artery stenosis and biliary strictures in liver transplant recipients

Sunil Dacha, Ashis Barad, John Martin, Josh Levitsky – 31 March 2011 – Biliary complications are important causes of morbidity and graft failure in patients after orthotopic liver transplantation. Nonanastomotic biliary strictures (NAS) are frequently the most challenging biliary complications. Hepatic artery stenosis (HAS) as a cause of biliary strictures has not been studied well systematically.

Should possible recurrence of disease contraindicate liver transplantation in patients with end‐stage alveolar echinococcosis? A 20‐year follow‐up study

Solange Bresson‐Hadni, Oleg Blagosklonov, Jenny Knapp, Frédéric Grenouillet, Yasuhito Sako, Eric Delabrousse, Marie‐Pascale Brientini, Carine Richou, Anne Minello, Anca‐Teodora Antonino, Michel Gillet, Akira Ito, Georges André Mantion, Dominique Angèle Vuitton – 31 March 2011 – Liver transplantation (LT) is currently contraindicated in patients with residual or metastatic alveolar echinococcosis (AE) lesions. We evaluated the long‐term course of such patients who underwent LT and were subsequently treated with benzimidazoles.

Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion

Danijela Petrovic, Zania Stamataki, Eugene Dempsey, Lucy Golden‐Mason, Michael Freeley, Derek Doherty, David Prichard, Catherine Keogh, Jennifer Conroy, Siobhan Mitchell, Yuri Volkov, Jane A. McKeating, Cliona O'Farrelly, Dermot Kelleher, Aideen Long – 30 March 2011 – T cell activation and the resultant production of interleukin (IL‐2) is a central response of the adaptive immune system to pathogens, such as hepatitis C virus (HCV). HCV uses several mechanisms to evade both the innate and adaptive arms of the immune response.

p19ARF/p14ARF controls oncogenic functions of signal transducer and activator of transcription 3 in hepatocellular carcinoma

Doris Schneller, Georg Machat, Alexandra Sousek, Verena Proell, Franziska van Zijl, Gudrun Zulehner, Heidemarie Huber, Markus Mair, Markus K. Muellner, Sebastian M.B. Nijman, Robert Eferl, Richard Moriggl, Wolfgang Mikulits – 30 March 2011 – Signal transducer and activator of transcription 3 (Stat3) is activated in a variety of malignancies, including hepatocellular carcinoma (HCC). Activation of Ras occurs frequently at advanced stages of HCC by aberrant signaling through growth factor receptors or inactivation of effectors negatively regulating Ras signaling.

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