Comparison of the sequential organ failure assessment score with the King's College Hospital criteria and the model for end‐stage liver disease score for the prognosis of acetaminophen‐induced acute liver failure

Evangelos Cholongitas, Eleni Theocharidou, Panayota Vasianopoulou, Alex Betrosian, Steve Shaw, David Patch, James O'Beirne, Banwari Agarwal, Andrew K. Burroughs – 23 December 2011 – Acetaminophen‐induced acute liver failure (ALF) is a complex multiorgan illness. An assessment of the prognosis is essential for the accurate identification of patients for whom survival without liver transplantation (LT) is unlikely.

Retinoic acid receptor–related orphan receptor α–induced activation of adenosine monophosphate–activated protein kinase results in attenuation of hepatic steatosis

Eun‐Jin Kim, Young‐Sil Yoon, Suckchang Hong, Ho‐Young Son, Tae‐Young Na, Min‐Ho Lee, Hyun‐Jin Kang, Jinyoung Park, Won‐Jea Cho, Sang‐Gun Kim, Seung‐Hoi Koo, Hyeung‐geun Park, Mi‐Ock Lee – 20 December 2011 – There is increasing evidence that the retinoic acid receptor–related orphan receptor α (RORα) plays an important role in the regulation of metabolic pathways, particularly of fatty acid and cholesterol metabolism; however, the role of RORα in the regulation of hepatic lipogenesis has not been studied.

Suppression of interferon‐α signaling by hepatitis E virus

Chen Dong, Mohammad Zafrullah, Tonya Mixson‐Hayden, Xing Dai, Jiuhong Liang, Jihong Meng, Saleem Kamili – 20 December 2011 – The interferon (IFN) system is integral to the host response against viruses, and many viruses have developed strategies to overcome its antiviral effects. The effects of hepatitis E virus (HEV), the causative agent of hepatitis E, on IFN signaling have not been investigated primarily because of the nonavailability of an efficient in vitro culture system or small animal models of infection.

Hepatic endothelin‐1 and endocannabinoids‐dependent effects of hyperleptinemia in nonalcoholic steatohepatitis‐cirrhotic rats

Ying‐Ying Yang, Tung‐Hu Tsai, Yi‐Tsau Huang, Tzung‐Yan Lee, Che‐Chang Chan, Kuei‐Chuan Lee, Han‐Chieh Lin – 20 December 2011 – Leptin, the ob gene product, is a protein released from adipocytes and has been detected in fibrotic and cirrhotic livers. Leptin in brain has an inhibitory effect on food intake. Nonalcoholic steatohepatitis (NASH) is characterized by hyperleptinemia. This study explores the possible mechanisms of hyperleptinemia in relation to increased intrahepatic resistance (IHR) and portal hypertension in NASH cirrhotic rats.

Outcomes of curative treatment for hepatocellular cancer in nonalcoholic steatohepatitis versus hepatitis C and alcoholic liver disease

Srinevas K. Reddy, Jennifer L. Steel, Hui‐Wei Chen, David J. DeMateo, Jon Cardinal, Jaideep Behari, Abhinav Humar, J. Wallis Marsh, David A. Geller, Allan Tsung – 20 December 2011 – Concomitant increasing incidences of hepatocellular carcinoma (HCC) and nonalcoholic steatohepatitis (NASH) suggest that a substantial proportion of HCC arises as a result of hepatocellular injury from NASH.

Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease

Romina Lomonaco, Carolina Ortiz‐Lopez, Beverly Orsak, Amy Webb, Jean Hardies, Celia Darland, Joan Finch, Amalia Gastaldelli, Stephen Harrison, Fermin Tio, Kenneth Cusi – 20 December 2011 – The role of adipose tissue insulin resistance in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains unclear.

Subscribe to