Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathways

Jens U. Marquardt, Chiara Raggi, Jesper B. Andersen, Daekwan Seo, Itzhak Avital, David Geller, Yun‐Han Lee, Mitsuteru Kitade, Agnes Holczbauer, Matthew C. Gillen, Elizabeth A. Conner, Valentina M. Factor, Snorri S. Thorgeirsson – 26 May 2011 – Epigenetic mechanisms play critical roles in stem cell biology by maintaining pluripotency of stem cells and promoting differentiation of more mature derivatives.

Molecular imaging of hepatic stellate cell activity by visualization of hepatic integrin αvβ3 expression with SPECT in rat

Feng Li, Zhengji Song, Qinghua Li, Jian Wu, Jiyao Wang, Cao Xie, Chuantao Tu, Jian Wang, Xiaowei Huang, Weiyue Lu – 26 May 2011 – The key factors in the pathogenesis of liver fibrosis are the activation and proliferation of hepatic stellate cells (HSCs), which express integrin αvβ3 after activation. This study aimed to explore the potential of 99mTc‐labeled cyclic arginine‐glycine‐aspartic acid pentapeptide (cRGD) as a single photon emission computed tomography (SPECT) radiotracer to image hepatic integrin αvβ3 expression to reflect HSC activity in fibrotic livers.

Safety of liver transplantation with chagas disease–seropositive donors for seronegative recipients

Fernando Salvador, Oscar Len, Israel Molina, Elena Sulleiro, Silvia Sauleda, Itxarone Bilbao, Lluis Castells, Teresa Pont, Joan Gavaldà, Albert Pahissa – 26 May 2011 – The shortage of organs for transplantation has prompted the investigation of extended criteria donors, such as donors with transmissible infectious diseases. Here we report our recent experience with liver transplantation using organs from donors who were serologically positive for Chagas disease. We also provide a review of the literature and emphasize donor screening and preventive measures.

Effect of telaprevir on the pharmacokinetics of cyclosporine and tacrolimus

Varun Garg, Rolf van Heeswijk, Jee Eun Lee, Katia Alves, Priya Nadkarni, Xia Luo – 26 May 2011 – The hepatitis C virus protease inhibitor telaprevir is an inhibitor of the enzyme cytochrome P450 3A, responsible for the metabolism of both cyclosporine and tacrolimus. This Phase I, open‐label, nonrandomized, single‐sequence study assessed the effect of telaprevir coadministration on the pharmacokinetics of a single dose of either cyclosporine or tacrolimus in two separate panels of 10 healthy volunteers each.

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