Interleukin 2 receptor antagonists for liver transplant recipients: A systematic review and meta‐analysis of controlled studies

Armin D. Goralczyk, Nicola Hauke, Narin Bari, Tung Y. Tsui, Thomas Lorf, Aiman Obed – 21 April 2011 – Interleukin 2 receptor antagonists (IL‐2Ra) are frequently used as induction therapy in liver transplant recipients to decrease the risk of acute rejection while allowing the reduction of concomitant immunosuppression. We conducted a systematic review of prospective, controlled studies to test the hypothesis that the use of IL‐2Ra is associated with a decrease in acute rejection and/or a decrease in the side effects of concomitant medication.

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Josep Maria Orellana‐Gavaldà, Laura Herrero, Maria Ida Malandrino, Guillermina Asins, Fausto G. Hegardt, Dolores Serra – 21 April 2011

Block of proliferation 1 (BOP1) plays an oncogenic role in hepatocellular carcinoma by promoting epithelial‐to‐mesenchymal transition

Kit‐Ying Chung, Ibis K.‐C. Cheng, Arthur K.‐K. Ching, Jian‐Hong Chu, Paul B.‐S. Lai, Nathalie Wong – 21 April 2011 – Genomic amplification of regional chromosome 8q24 is a common event in human cancers. In hepatocellular carcinoma (HCC), a highly aggressive malignancy that is rapidly fatal, recurrent 8q24 gains can be detected in >50% of cases. In this study, attempts to resolve the 8q24 region by way of array comparative genomic hybridization for affected genes in HCC revealed distinctive gains of block of proliferation 1 (BOP1).

Chest computed tomography is more likely to show latent tuberculosis foci than simple chest radiography in liver transplant candidates

Jiwon Lyu, Sung‐Gyu Lee, Shin Hwang, Sang‐Oh Lee, Oh‐Hyun Cho, Eun Jin Chae, Sang Do Lee, Woo Sung Kim, Dong Soon Kim, Tae Sun Shim – 19 April 2011 – Although the detection and treatment of latent tuberculosis infections (LTBIs) in transplant candidates are essential, current diagnostic methods for LTBIs are limited, especially in immunocompromised subjects. Pretransplant chest computed tomography (CT) may reveal more LTBI foci and thus predict the development of posttransplant tuberculosis (TB) more efficiently; however, this hypothesis has not yet been investigated.

Pediatric liver transplantation for primary sclerosing cholangitis

Tamir Miloh, Ravinder Anand, Wendy Yin, Miriam Vos, Nanda Kerkar, Estella Alonso, for the Studies of Pediatric Liver Transplantation Research Group – 19 April 2011 – Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease in children. The aim of this study was to determine the characteristics and outcomes of children with PSC who were listed for liver transplantation (LT).

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