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Hepatitis C virus–infected women have a higher risk of advanced fibrosis and graft loss after liver transplantation than men

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Jennifer C. Lai, Elizabeth C. Verna, Robert S. Brown, Jacqueline G. O'Leary, James F. Trotter, Lisa M. Forman, Jeffrey D. Duman, Richard G. Foster, R. Todd Stravitz, Norah A. Terrault, for the Consortium to Study Health Outcomes in HCV Liver Transplant Recipients (CRUSH‐C) – 28 April 2011 – In natural history studies of hepatitis C virus (HCV) infection, women have a lower risk of disease progression to cirrhosis. Whether female sex influences outcomes of HCV in the posttransplantation setting is unknown.

Hepatic organic anion transporting polypeptide transporter and thyroid hormone receptor interplay determines cholesterol and glucose homeostasis

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Henriette E. Meyer zu Schwabedissen, Joseph A. Ware, David Finkelstein, Amarjit S. Chaudhry, Sara Mansell, Matilde Leon‐Ponte, Stephen C. Strom, Hani Zaher, Ute I. Schwarz, David J. Freeman, Erin G. Schuetz, Rommel G. Tirona, Richard B. Kim – 28 April 2011 – The role of organic anion transporting polypeptides (OATPs), particularly the members of OATP1B subfamily, in hepatocellular handling of endogenous and exogenous compounds is an important and emerging area of research.

Electrostatic modifications of the human leukocyte antigen DR P9 peptide‐binding pocket in primary sclerosing cholangitis: Back to the future with human leukocyte antigen DRβ

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Peter T. Donaldson – 28 April 2011

Critical role of tumor necrosis factor receptor 1, but not 2, in hepatic stellate cell proliferation, extracellular matrix remodeling, and liver fibrogenesis

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Núria Tarrats, Anna Moles, Albert Morales, Carmen García‐Ruiz, José C. Fernández‐Checa, Montserrat Marí – 26 April 2011 – Tumor necrosis factor (TNF) has been implicated in the progression of many chronic liver diseases leading to fibrosis; however, the role of TNF in fibrogenesis is controversial and the specific contribution of TNF receptors to hepatic stellate cell (HSC) activation remains to be established.

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Zachary Goodman, Hala Makhlouf, Zobair Younossi – 26 April 2011

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Nazim A. Ghouri, David Preiss, Naveed Sattar – 22 April 2011

The hepcidin circuits act: Balancing iron and inflammation

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Bryan D. Maliken, James E. Nelson, Kris V. Kowdley – 22 April 2011 – Hepcidin is a peptide hormone that regulates iron homeostasis and acts as an antimicrobial peptide. It is expressed and secreted by a variety of cell types in response to iron loading and inflammation. Hepcidin mediates iron homeostasis by binding to the iron exporter ferroportin, inducing its internalization and degradation via activation of the protein kinase Jak2 and the subsequent phosphorylation of ferroportin.