Clinical trials and their translation in hepatology: Past, present, and future
E. Jenny Heathcote – 27 December 2011
Gilbert syndrome redefined: A complex genetic haplotype influences the regulation of glucuronidation
Ursula Ehmer, Sandra Kalthoff, Bastian Fakundiny, Brigitte Pabst, Nicole Freiberg, Ronald Naumann, Michael P. Manns, Christian P. Strassburg – 27 December 2011 – Gilbert syndrome (GS) is characterized by intermittent unconjugated hyperbilirubinemia without structural liver damage, affecting about 10% of the white population. In GS the UGT1A1*28 variant reduces bilirubin conjugation by 70% and is associated with irinotecan and protease inhibitor side effects. The aim of this study was to characterize potential in vivo consequences of UGT1A gene variability in GS.
Galectin‐3 deficiency prevents concanavalin A–induced hepatitis in mice
Vladislav Volarevic, Marija Milovanovic, Biljana Ljujic, Nada Pejnovic, Nebojsa Arsenijevic, Ulf Nilsson, Hakon Leffler, Miodrag L. Lukic – 24 December 2011 – We used concanavalin A (Con A)‐induced liver injury to study the role of galectin‐3 (Gal‐3) in the induction of inflammatory pathology and hepatocellular damage.
Outcomes after liver transplantation for alcoholic hepatitis are similar to alcoholic cirrhosis: Exploratory analysis from the UNOS database
Ashwani K. Singal, Hmoud Bashar, Bhupinderjit S. Anand, Sarat C. Jampana, Vineet Singal, Yong‐Fang Kuo – 24 December 2011 – Data on liver transplantation for patients with alcoholic hepatitis are limited. Using the United Network for Organ Sharing database (2004‐2010), adults undergoing liver transplantation for a listing diagnosis of alcoholic hepatitis were matched for age, gender, ethnicity, and model for endstage disease (MELD) score, donor risk index, and year of transplantation with three patients transplanted for a listing diagnosis of alcoholic cirrhosis.
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Massimo Iavarone, Giuseppe Cabibbo, Massimo Colombo – 24 December 2011
Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease
Shelby Sullivan, Erik P. Kirk, Bettina Mittendorfer, Bruce W. Patterson, Samuel Klein – 24 December 2011 – Nonalcoholic fatty liver disease (NAFLD) and alterations in hepatic lipoprotein kinetics are common metabolic complications associated with obesity. Lifestyle modification involving diet‐induced weight loss and regular exercise decreases intrahepatic triglyceride (IHTG) content and very low density lipoprotein (VLDL) triglyceride (TG) secretion rate.
Argininosuccinate synthase conditions the response to acute and chronic ethanol‐induced liver injury in mice
Tung Ming Leung, Yongke Lu, Wei Yan, José A. Morón‐Concepción, Stephen C. Ward, Xiaodong Ge, Laura Conde de la Rosa, Natalia Nieto – 24 December 2011 – Argininosuccinate synthase (ASS) is the rate‐limiting enzyme in both the urea and the L‐citrulline/nitric oxide (NO·) cycles regulating protein catabolism, ammonia levels, and NO· generation.
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Bruno Sangro, for the European Network on Radioembolization With Yttrium‐90 Resin Microspheres – 24 December 2011
Comparison of the sequential organ failure assessment score with the King's College Hospital criteria and the model for end‐stage liver disease score for the prognosis of acetaminophen‐induced acute liver failure
Evangelos Cholongitas, Eleni Theocharidou, Panayota Vasianopoulou, Alex Betrosian, Steve Shaw, David Patch, James O'Beirne, Banwari Agarwal, Andrew K. Burroughs – 23 December 2011 – Acetaminophen‐induced acute liver failure (ALF) is a complex multiorgan illness. An assessment of the prognosis is essential for the accurate identification of patients for whom survival without liver transplantation (LT) is unlikely.
Sharpen your look on liver progenitor cells
Laurent Dollé, Konrad L. Streetz, Leo A. van Grunsven – 21 December 2011