Carcinogen‐induced hepatic tumors in KLF6+/− mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation

Mirko Tarocchi, Rebekka Hannivoort, Yujin Hoshida, Ursula E. Lee, Diana Vetter, Goutham Narla, Augusto Villanueva, Moshe Oren, Josep M. Llovet, Scott L. Friedman – 11 May 2011 – Inactivation of KLF6 is common in hepatocellular carcinoma (HCC) associated with hepatitis C virus (HCV) infection, thereby abrogating its normal antiproliferative activity in liver cells. The aim of the study was to evaluate the impact of KLF6 depletion on human HCC and experimental hepatocarcinogenesis in vivo.

Mouse patatin‐like phospholipase domain‐containing 3 influences systemic lipid and glucose homeostasis

Aijun Qiao, Jichao Liang, Yaojun Ke, Chenghong Li, Ying Cui, Lian Shen, Huabing Zhang, Anfang Cui, Xiaojun Liu, Changzheng Liu, Yong Chen, Yi Zhu, Youfei Guan, Fude Fang, Yongsheng Chang – 5 May 2011 – Human patatin‐like phospholipase domain‐containing 3 (PNPLA3) is associated with increased liver fat content and liver injury. Here, we show that nutritional status regulates PNPLA3 gene expression in the mouse liver. Sterol response element binding protein‐1 (SREBP‐1) activated PNPLA3 gene transcription via sterol regulatory elements (SREs) mapped to the promoter region.

Impact of portal venous hemodynamics on indices of liver function and graft regeneration after right lobe living donor liver transplantation

Ting‐Jung Wu, Divya Dahiya, Ching‐Sung Lee, Chen‐Fang Lee, Hong‐Shiue Chou, Kun‐Ming Chan, Wei‐Chen Lee – 3 May 2011 – The aim of this study was to evaluate the effects of portal hemodynamics on indices of liver function and graft regeneration in patients after adult right lobe living donor liver transplantation (R‐LDLT). Sixty‐four patients who underwent R‐LDLT and had an uneventful postoperative course were enrolled in this study. The contribution of portal flow was greater to the recipient grafts versus the donor livers (90.74% versus 69.12%, P < 0.0001).

Beneficial effects of supplementation with branched‐chain amino acids on postoperative bacteremia in living donor liver transplant recipients

Ken Shirabe, Masanori Yoshimatsu, Takashi Motomura, Kazuki Takeishi, Takeo Toshima, Jun Muto, Rumi Matono, Akinobu Taketomi, Hideaki Uchiyama, Yoshihiko Maehara – 3 May 2011 – The aim of this study was to investigate the effects of preoperative oral supplementation with branched‐chain amino acids (BCAAs) on postoperative bacteremia after living donor liver transplantation (LDLT) for chronic liver failure. Two hundred thirty‐six patients who underwent adult‐to‐adult LDLT were evaluated in this retrospective study.

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