Outcomes of orthotopic liver transplantation for hepatic sarcoidosis: An analysis of the United Network for organ sharing/organ Procurement and Transplantation Network data files for a comparative study with cholestatic liver diseases

Jason M. Vanatta, Kian A. Modanlou, Amanda G. Dean, Nosratollah Nezakatgoo, Luis Campos, Satheesh Nair, James D. Eason – 18 May 2011 – Hepatic sarcoidosis is a rare indication for liver transplantation. Using the United Network for Organ Sharing (UNOS)/Organ Procurement and Transplantation Network (OPTN) database, we evaluated patient and graft survival after orthotopic liver transplantation for sarcoidosis between October 1987 and December 2007.

Use of an upper midline incision for living donor partial hepatectomy: A series of 143 consecutive cases

Kwang‐Woong Lee, Seong Hoon Kim, Sung‐Sik Han, Young‐Kyu Kim, Seong Yeon Cho, Tae You, Sang‐Jae Park – 16 May 2011 – Over a period of 2 years, we used an upper midline incision (UMI) without laparoscopic assistance in 143 consecutive living donor partial hepatectomy (LDPH) procedures, regardless of the graft type or the donor age, sex, body mass index, or body shape. Here we report surgical recommendations based on our experience with the use of UMIs in this context.

Toll‐like receptor 4 and myeloid differentiation factor 88 provide mechanistic insights into the cause and effects of interleukin‐6 activation in mouse liver regeneration

Javier Vaquero, Jean S. Campbell, Jamil Haque, Ryan S. McMahan, Kimberly J. Riehle, Renay L. Bauer, Nelson Fausto – 13 May 2011 – Partial hepatectomy (PH) consistently results in an early increase of circulating interleukin‐6 (IL‐6), which is thought to play a major role in liver regeneration. Activation of this cytokine after PH requires the adaptor protein, MyD88, but the specific MyD88‐related receptors involved remain unidentified. It is also unknown whether the magnitude of IL‐6 elevation determines the extent of subsequent hepatocyte proliferation.

Characterization of fecal microbial communities in patients with liver cirrhosis

Yanfei Chen, Fengling Yang, Haifeng Lu, Baohong Wang, Yunbo Chen, Dajiang Lei, Yuezhu Wang, Baoli Zhu, Lanjuan Li – 13 May 2011 – Liver cirrhosis is the pathologic end stage of chronic liver disease. Increasing evidence suggests that gut flora is implicated in the pathogenesis of liver cirrhosis complications. The aim of this study was to characterize the fecal microbial community in patients with liver cirrhosis in comparison with healthy individuals. We recruited 36 patients with liver cirrhosis and 24 healthy controls.

Idiopathic noncirrhotic portal hypertension

Jeoffrey N.L. Schouten, Juan C. Garcia‐Pagan, Dominique C. Valla, Harry L.A. Janssen – 13 May 2011 – Idiopathic noncirrhotic portal hypertension (INCPH) is characterized by an increased portal venous pressure gradient in the absence of a known cause of liver disease and portal vein thrombosis. In contrast to the high prevalence of this disorder in India, INCPH is a rare disease in the Western world. The etiology of INCPH can be divided in five categories: chronic infections, exposure to medication or toxins, thrombophilia, immunological disorders, and genetic disorders.

Genomewide microRNA down‐regulation as a negative feedback mechanism in the early phases of liver regeneration

Jingmin Shu, Betsy T. Kren, Zhilian Xia, Phillip Y.‐P. Wong, Lihua Li, Eric A. Hanse, Michael X. Min, Bingshan Li, Jeffrey H. Albrecht, Yan Zeng, Subbaya Subramanian, Clifford J. Steer – 13 May 2011 – The liver is one of the few organs that have the capacity to regenerate in response to injury. We carried out genomewide microRNA (miRNA) microarray studies during liver regeneration in rats after 70% partial hepatectomy (PH) at early and mid time points to more thoroughly understand their role. At 3, 12, and 18 hours post‐PH ∼40% of the miRNAs tested were up‐regulated.

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