MicroRNAs‐372/373 promote the expression of hepatitis B virus through the targeting of nuclear factor I/B

Hongyan Guo, Haiying Liu, Keith Mitchelson, Huiying Rao, Mingyong Luo, Lan Xie, Yimin Sun, Liang Zhang, Ying Lu, Ruyu Liu, Aihui Ren, Shuai Liu, Shaozhen Zhou, Jiye Zhu, Yuxiang Zhou, Ailong Huang, Lai Wei, Yong Guo, Jing Cheng – 23 May 2011 – MicroRNAs (miRNAs) play important roles in the posttranscriptional regulation of gene expression. Recent evidence has indicated the pathological relevance of miRNA dysregulation in hepatitis virus infection; however, the roles of microRNAs in the regulation of hepatitis B virus (HBV) expression are still largely unknown.

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Hitendra Garg, Shiv Kumar Sarin, Manoj Kumar, Vishal Garg, Barjesh Chander Sharma, Ashish Kumar – 23 May 2011

Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: Short‐term and long‐term outcomes

Liang Peng, Dong‐ying Xie, Bing‐Liang Lin, Jing Liu, Hai‐peng Zhu, Chan Xie, Yu‐bao Zheng, Zhi‐liang Gao – 23 May 2011 – Our study aimed to investigate the short‐term efficacy and long‐term prognosis of liver failure patients caused by hepatitis B after a single transplantation with autologous marrow mesenchymal stem cells (MMSCs). A total of 527 inpatients with liver failure caused by hepatitis B were recruited and received the same medical treatments, among whom 53 patients underwent a single transplantation with autologous MMSCs.

Risk factors for long‐term mortality in a large cohort of patients wait‐listed for liver transplantation in Brazil

Samanta T. Basto, Cristiane A. Villela‐Nogueira, Bernardo R. Tura, Henrique Sergio M. Coelho, Joaquim Ribeiro, Eduardo S. M. Fernandes, Alice F. Schmal, Livia Victor, Ronir R. Luiz, Renata M. Perez – 20 May 2011 – Liver donor shortage and long waiting times are observed in many liver transplant programs worldwide. The aim of this study was to evaluate the wait list in a developing country, before and after the introduction of the MELD scoring system. In addition, the MELD score ability to predict mortality in this setting was assessed.

Impact of center volume on outcomes of increased‐risk liver transplants

Deepak K. Ozhathil, You Fu Li, Jillian K. Smith, Jennifer F. Tseng, Reza F. Saidi, Adel Bozorgzadeh, Shimul A. Shah – 20 May 2011 – The use of high‐risk donor livers, which is reflective of the gross national shortage of organs available for transplantation, has gained momentum. Despite the demand, many marginal livers are discarded annually. We evaluated the impact of center volume on survival outcomes associated with liver transplantation using high–donor risk index (DRI) allografts.

Ambivalence in living liver donors

Mary Ann Simpson, Julia Kendrick, Jennifer E. Verbesey, Denise S. Morin, Mary Amanda Dew, Agnes Trabucco, James J. Pomposelli, Elizabeth A. Pomfret – 20 May 2011 – All right hepatic lobe (RHL) donors in our program are asked to participate in a longitudinal quality‐of‐life study that begins at their evaluation and continues throughout the first postdonation year. Here we report the characteristics of donor candidates who completed the donation process despite ambivalence. In all, 183 RHL candidates consented, and 133 became donors.

Liver transplantation for erythropoietic protoporphyria in Europe

Staffan Wahlin, Per Stal, Rene Adam, Vincent Karam, Robert Porte, Daniel Seehofer, Bridget K. Gunson, Jens Hillingsø, Jürgen L. Klempnauer, Jan Schmidt, Graeme Alexander, John O'Grady, Pierre‐Alain Clavien, Mauro Salizzoni, Andreas Paul, Keith Rolles, Bo‐Göran Ericzon, Pauline Harper, for the European Liver and Intestine Transplant Association – 20 May 2011 – Liver transplantation is an established lifesaving treatment for patients with severe protoporphyric liver disease, but disease recurrence in the graft occurs for the majority of recipients.

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