Rachel Tanos, Rushang D. Patel, Iain A. Murray, Philip B. Smith, Andrew D. Patterson, Gary H. Perdew – 11 January 2012 – The aryl hydrocarbon receptor (AhR) is a ligand‐activated transcription factor. Activation of AhR mediates the expression of target genes (e.g., CYP1A1) by binding to dioxin response element (DRE) sequences in their promoter region.
Lin Liu, Brian E. Fisher, David L. Thomas, Andrea L. Cox, Stuart C. Ray – 11 January 2012 – The aim of this study is to determine whether early viral dynamics and evolution predict outcome of primary acute hepatitis C virus (HCV) infection. HCV‐ and human immunodeficiency virus–negative injection drug users were enrolled prospectively and followed monthly to identify acute HCV infection using RNA detection. Subjects with more than 1 month between HCV‐RNA‐negative and ‐positive visits were excluded to ensure stringent acute infection.
H. Carlijne Hassing, Hans Mooij, Shuling Guo, Brett P. Monia, Keyang Chen, Wim Kulik, Geesje M. Dallinga‐Thie, Max Nieuwdorp, Erik S.G. Stroes, Kevin Jon Williams – 11 January 2012 – Type 2 diabetes mellitus (T2DM) impairs hepatic clearance of atherogenic postprandial triglyceride‐rich lipoproteins (TRLs). We recently reported that livers from T2DM db/db mice markedly overexpress the heparan sulfate glucosamine‐6‐O‐endosulfatase‐2 (SULF2), an enzyme that removes 6‐O sulfate groups from heparan sulfate proteoglycans (HSPGs) and suppresses uptake of TRLs by cultured hepatocytes.
Jae Yeon Seok, Deuk Chae Na, Hyun Goo Woo, Massimo Roncalli, So Mee Kwon, Jeong Eun Yoo, Ei Yong Ahn, Gwang Il Kim, Jin‐Sub Choi, Young Bae Kim, Young Nyun Park – 11 January 2012 – Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major primary liver cancers in adults. The phenotypic overlap between HCC and CC has been shown to comprise a continuous liver cancer spectrum.
Wei Yan, Ying Chang, Xiaoyan Liang, Jon S. Cardinal, Hai Huang, Stephen H. Thorne, Satdarshan P.S. Monga, David A. Geller, Michael T. Lotze, Allan Tsung – 11 January 2012 – Hypoxia is often found in solid tumors and is associated with tumor progression and poor clinical outcomes. The exact mechanisms related to hypoxia‐induced invasion and metastasis remain unclear.
Janett Fischer, Stephan Böhm, Markus Scholz, Tobias Müller, Heiko Witt, Jacob George, Christoph Sarrazin, Simone Susser, Eckart Schott, Vijayaprakash Suppiah, David R. Booth, Graeme J. Stewart, Florian van Bömmel, Annika Brodzinski, Balazs Fülöp, Pascal Migaud, Thomas Berg – 11 January 2012 – In patients with chronic hepatitis C virus (HCV) infection, several variants of the interleukin‐28B (IL28B) gene have been shown to correlate significantly with a sustained virologic response (SVR).
Clifford J. Steer, Subbaya Subramanian – 9 January 2012
Pothakamuri Venkata Suneetha, Sven Pischke, Heiner Wedemeyer – 4 January 2012
Luciano Silvestri, Miguel A. de la Cal, Durk F. Zandstra, Nia Taylor, Hendrick K. F. van Saene – 4 January 2012
Domingo Balderramo, Oriol Sendino, Marta Burrel, Maria Isabel Real, Annabel Blasi, Graciela Martinez‐Palli, Josep M. Bordas, Juan Carlos Garcia‐Valdecasas, Antoni Rimola, Miguel Navasa, Josep Llach, Andres Cardenas – 4 January 2012 – Anastomotic strictures (ASs) of the biliary duct after liver transplantation (LT) are primarily managed with endoscopic retrograde cholangiopancreatography (ERCP), but in some cases, this fails because of difficulties in passing the strictures.