Saffron: A potential candidate for a novel anticancer drug against hepatocellular carcinoma

Amr Amin, Alaaeldin A. Hamza, Khuloud Bajbouj, S. Salman Ashraf, Sayel Daoud – 23 May 2011 – Saffron has been proposed as a promising candidate for cancer chemoprevention. The purpose of this investigation was to investigate the chemopreventive action and the possible mechanisms of saffron against diethylnitrosamine (DEN)‐induced liver cancer in rats. Administration of saffron at doses of 75, 150, and 300 mg/kg/day was started 2 weeks prior to the DEN injection and was continued for 22 weeks.

MicroRNAs‐372/373 promote the expression of hepatitis B virus through the targeting of nuclear factor I/B

Hongyan Guo, Haiying Liu, Keith Mitchelson, Huiying Rao, Mingyong Luo, Lan Xie, Yimin Sun, Liang Zhang, Ying Lu, Ruyu Liu, Aihui Ren, Shuai Liu, Shaozhen Zhou, Jiye Zhu, Yuxiang Zhou, Ailong Huang, Lai Wei, Yong Guo, Jing Cheng – 23 May 2011 – MicroRNAs (miRNAs) play important roles in the posttranscriptional regulation of gene expression. Recent evidence has indicated the pathological relevance of miRNA dysregulation in hepatitis virus infection; however, the roles of microRNAs in the regulation of hepatitis B virus (HBV) expression are still largely unknown.

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Hitendra Garg, Shiv Kumar Sarin, Manoj Kumar, Vishal Garg, Barjesh Chander Sharma, Ashish Kumar – 23 May 2011

Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: Short‐term and long‐term outcomes

Liang Peng, Dong‐ying Xie, Bing‐Liang Lin, Jing Liu, Hai‐peng Zhu, Chan Xie, Yu‐bao Zheng, Zhi‐liang Gao – 23 May 2011 – Our study aimed to investigate the short‐term efficacy and long‐term prognosis of liver failure patients caused by hepatitis B after a single transplantation with autologous marrow mesenchymal stem cells (MMSCs). A total of 527 inpatients with liver failure caused by hepatitis B were recruited and received the same medical treatments, among whom 53 patients underwent a single transplantation with autologous MMSCs.

Risk factors for long‐term mortality in a large cohort of patients wait‐listed for liver transplantation in Brazil

Samanta T. Basto, Cristiane A. Villela‐Nogueira, Bernardo R. Tura, Henrique Sergio M. Coelho, Joaquim Ribeiro, Eduardo S. M. Fernandes, Alice F. Schmal, Livia Victor, Ronir R. Luiz, Renata M. Perez – 20 May 2011 – Liver donor shortage and long waiting times are observed in many liver transplant programs worldwide. The aim of this study was to evaluate the wait list in a developing country, before and after the introduction of the MELD scoring system. In addition, the MELD score ability to predict mortality in this setting was assessed.

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