Ethanol facilitates hepatitis C virus replication via up‐regulation of GW182 and heat shock protein 90 in human hepatoma cells

Terence N. Bukong, Wei Hou, Karen Kodys, Gyongyi Szabo – 16 August 2012 – Alcohol use and hepatitis C virus (HCV) infection synergize to cause liver damage, and microRNA‐122 (miR‐122) appears to play a key role in this process. Argonaute 2 (Ago2), a key component of the RNA‐induced silencing complex (RISC), has been shown to be important in modulating miR‐122 function during HCV infection. However, GW182, a critical component of processing bodies (GW bodies) that is recruited by Ago2 to target messenger RNA (mRNA), has not been assessed in HCV infection.

Directly acting drugs prostacyclin or nitroglycerine and endothelin receptor blocker bosentan improve cell engraftment in rodent liver

Ralf Bahde, Sorabh Kapoor, Sriram Bandi, Kuldeep K. Bhargava, Christopher J. Palestro, Sanjeev Gupta – 16 August 2012 – To optimize strategies for liver‐directed cell therapy, prevention of initial transplanted cell losses is particularly important for subsequent liver repopulation. After cell transplantation in hepatic sinusoids, perturbations in hepatic microcirculation along with changes in various liver cell types are among the earliest changes.

Hepatic transforming growth factor beta gives rise to tumor‐initiating cells and promotes liver cancer development

Kun Wu, Jin Ding, Cheng Chen, Wen Sun, Bei‐Fang Ning, Wen Wen, Lei Huang, Tao Han, Wen Yang, Chao Wang, Zhong Li, Meng‐Chao Wu, Gen‐Sheng Feng, Wei‐Fen Xie, Hong‐Yang Wang – 16 August 2012 – Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC). However, the mechanism underlying the progression from cirrhosis to HCC remains unclear. Herein we report the concurrent increase of liver progenitor cells (LPCs) and transforming growth factor‐β (TGF‐β) in diethylnitrosamine (DEN)‐induced rat hepatocarcinogenesis and cirrhotic livers of HCC patients.

FGF3/FGF4 amplification and multiple lung metastases in responders to sorafenib in hepatocellular carcinoma

Tokuzo Arao, Kazuomi Ueshima, Kazuko Matsumoto, Tomoyuki Nagai, Hideharu Kimura, Satoru Hagiwara, Toshiharu Sakurai, Seiji Haji, Akishige Kanazawa, Hisashi Hidaka, Yukihiro Iso, Keiichi Kubota, Mitsuo Shimada, Tohru Utsunomiya, Masashi Hirooka, Yoichi Hiasa, Yoshikazu Toyoki, Kenichi Hakamada, Kohichiroh Yasui, Takashi Kumada, Hidenori Toyoda, Shuichi Sato, Hiroyuki Hisai, Teiji Kuzuya, Kaoru Tsuchiya, Namiki Izumi, Shigeki Arii, Kazuto Nishio, Masatoshi Kudo – 13 August 2012 – The response rate to sorafenib in hepatocellular carcinoma (HCC) is relatively low (0.7%‐3%), however, rapid and d

Clinical yield of diagnostic endoscopic retrograde cholangiopancreatography in orthotopic liver transplant recipients With suspected biliary complications

B. Joseph Elmunzer, Anthony T. DeBenedet, Michael L. Volk, Christopher J. Sonnenday, Akbar K. Waljee, Robert J. Fontana, Aarti B. Oza, Amit Singal, Michael J. Englesbe, James M. Scheiman – 10 August 2012 – Diagnostic endoscopic retrograde cholangiopancreatography (D‐ERCP) is commonly performed for the evaluation of biliary complications after orthotopic liver transplantation (OLT). This practice is contrary to the national trend of reserving endoscopic retrograde cholangiopancreatography (ERCP) for therapeutic purposes.

Progressive graft fibrosis and donor‐specific human leukocyte antigen antibodies in pediatric late liver allografts

Aya Miyagawa‐Hayashino, Atushi Yoshizawa, Yoichiro Uchida, Hiroto Egawa, Kimiko Yurugi, Satohiro Masuda, Sachiko Minamiguchi, Taira Maekawa, Shinji Uemoto, Hironori Haga – 10 August 2012 – The role of donor‐specific anti‐human leukocyte antigen antibodies (DSAs) that develop late after living donor liver transplantation is unknown. Seventy‐nine pediatric recipients who had good graft function and underwent protocol liver biopsy more than 5 years after transplantation (median = 11 years, range = 5‐20 years) were reviewed.

Intravenous N‐acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: A placebo‐controlled clinical trial

Robert H. Squires, Anil Dhawan, Estella Alonso, Michael R. Narkewicz, Benjamin L. Shneider, Norberto Rodriguez‐Baez, Dominic Dell Olio, Saul Karpen, John Bucuvalas, Steven Lobritto, Elizabeth Rand, Philip Rosenthal, Simon Horslen, Vicky Ng, Girish Subbarao, Nanda Kerkar, David Rudnick, M. James Lopez, Kathleen Schwarz, Rene Romero, Scott Elisofon, Edward Doo, Patricia R. Robuck, Sharon Lawlor, Steven H.

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