Caroline Scholtes, Christophe Ramière, Dominique Rainteau, Laure Perrin‐Cocon, Claude Wolf, Lydie Humbert, Martine Carreras, Aurélie Guironnet‐Paquet, Fabien Zoulim, Ralf Bartenschlager, Vincent Lotteau, Patrice André, Olivier Diaz – 30 January 2012 – Hepatitis C virus (HCV) particles associate viral and lipoprotein moieties to form hybrid lipoviral particles (LVPs). Cell culture–produced HCV (HCVcc) and ex vivo–characterized LVPs primarily differ by their apolipoprotein (apo) B content, which is low for HCVcc, but high for LVPs.

Sarwa Darwish Murad, W. Ray Kim, Terry Therneau, Gregory J. Gores, Charles B. Rosen, James A. Martenson, Steven R. Alberts, Julie K. Heimbach – 30 January 2012 – We have previously reported excellent outcomes with liver transplantation for selected patients with early‐stage perihilar cholangiocarcinoma (CCA) following neoadjuvant chemoradiotherapy. Our aim was to identify predictors of dropout before transplantation and predictors of cancer recurrence after transplantation.

Haofeng Ji, Xiu‐da Shen, Yu Zhang, Feng Gao, Cynthia Y. Huang, William W. Chang, Coney Lee, Bibo Ke, Ronald W. Busuttil, Jerzy W. Kupiec‐Weglinski – 30 January 2012 – Hepatic ischemia/reperfusion injury (IRI) occurs in multiple clinical settings, including liver transplantation. The cyclic adenosine monophosphate (cAMP)–dependent protein kinase A (PKA) pathway inhibits hepatocellular apoptosis and regulates toll‐like receptor 4–triggered inflammation responses in vitro.

Kirsty Boyd, Barbara Kimbell, Scott Murray, John Iredale – 30 January 2012

Sanjeev K. Akkina, Sumeet K. Asrani, Yi Peng, Peter Stock, W. Ray Kim, Ajay K. Israni – 28 January 2012 – Because of the shortage of deceased donor organs, transplant centers accept organs from marginal deceased donors, including older donors. Organ‐specific donor risk indices have been developed to predict graft survival with various combinations of donor and recipient characteristics. Here we review the kidney donor risk index (KDRI) and the liver donor risk index (LDRI) and compare and contrast their strengths, limitations, and potential uses.

Riccardo Superina – 28 January 2012

Margaret A. Scull, Alexander Ploss – 27 January 2012

Gennaro D'Amico, Fabio Tine – 27 January 2012

Luca Valenti, Anna Alisi, Valerio Nobili – 27 January 2012

Julia B. Goodnough, Emilio Ramos, Elizabeta Nemeth, Tomas Ganz – 25 January 2012 – The hepatic peptide hormone hepcidin controls the duodenal absorption of iron, its storage, and its systemic distribution. Hepcidin production is often insufficient in chronic hepatitis C and alcoholic liver disease, leading to hyperabsorption of iron and its accumulation in the liver. Hepatocyte growth factor (HGF) and epidermal growth factor (EGF) mediate hepatic regeneration after liver injury. We examined the effect of these growth factors on hepcidin synthesis by hepatocytes.