Weiwei Tao, Siyu Chen, Guangsen Shi, Jinhu Guo, Ying Xu, Chang Liu – 2 July 2011 – Many aspects of energy metabolism, including glucose and lipid homeostasis and mitochondrial oxidative metabolism, are under precise control by the mammalian circadian clock. However, the molecular mechanism for coordinate integration of the circadian clock and various metabolic pathways is poorly understood. Here we show that BAF60a, a chromatin‐remodeling complex subunit, is rhythmically expressed in the liver of mice.

Sujit S. Nair, Anitha Bommana, Suresh B. Pakala, Kazufumi Ohshiro, Amanda J. Lyon, Sutas Suttiprapa, Maria V. Periago, Thewarach Laha, Peter J. Hotez, Jeffrey M. Bethony, Banchob Sripa, Paul J.

Indra Neil Guha, Robert P. Myers, Keyur Patel, Jayant A. Talwalkar – 2 July 2011 – Noninvasive biomarkers of liver fibrosis represent an intense area of research with the goals of improving patient care, disease stratification, and aiding the development of future antifibrotic therapies.

Ding‐Shinn Chen – 30 June 2011 – Viral hepatitis and its sequelae are important health problems worldwide, including Taiwan. For the last 40 years, Taiwan's scientists and health care providers have worked hard to control these sequelae, and the results have been excellent. The author, Ding‐Shinn Chen, had a key role in planning and establishing the control program in Taiwan, and participated in the endeavors from the very beginning.

Mohammad R. Ebrahimkhani, Isaac Mohar, Ian N. Crispe – 30 June 2011 – Antigen cross‐presentation is a principal function of specialized antigen‐presenting cells of bone marrow origin such as dendritic cells. Although these cells are sometimes known as “professional” antigen‐presenting cells, nonbone marrow‐derived cells may also act as antigen‐presenting cells.

Hai Huang, John Evankovich, Wei Yan, Gary Nace, Lemeng Zhang, Mark Ross, Xinghua Liao, Timothy Billiar, Jun Xu, Charles T. Esmon, Allan Tsung – 30 June 2011 – Sterile inflammatory insults are known to activate innate immunity and propagate organ damage through the recognition of extracellular damage‐associated molecular pattern (DAMP) molecules. Although DAMPs such as endogenous DNA and nuclear high‐mobility group box 1 have been shown to be critical in sterile inflammation, the role of nuclear histone proteins has not yet been investigated.

Hui‐Ling Ko, Ee‐Chee Ren – 30 June 2011 – It is well‐established that hepatitis B virus (HBV) infection is associated with the development of hepatocellular carcinoma (HCC), but patients with high viral DNA load have significantly higher risk. As host factors are required for efficient viral replication and may, therefore, contribute to high viral DNA load, we screened for host factors that can transcriptionally activate the HBV core promoter (HBVCP).

Qiuju Han, Cai Zhang, Jian Zhang, Zhigang Tian – 30 June 2011 – It is extensively accepted that hepatitis B virus (HBV) escapes from innate immunity by inhibiting type I interferon (IFN) production, but efficient intervention to reverse the immune tolerance is still not achieved.

Francesco Marabita, Alessio Aghemo, Stella De Nicola, Maria G. Rumi, Cristina Cheroni, Rossana Scavelli, Marco Crimi, Roberta Soffredini, Sergio Abrignani, Raffaele De Francesco, Massimo Colombo – 30 June 2011 – Polymorphisms in the interleukin‐28B (IL28B) region are associated with spontaneous and treatment‐induced viral clearance in hepatitis C virus (HCV) infection. Nevertheless, it is unknown whether genetic variation at the IL28B locus influences the natural history of chronic HCV infection.

Ezequiel Ridruejo, Raúl Adrover, Marcelo O. Silva – 30 June 2011